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Identification, degradation characteristics, and application of a newly isolated pyridine-degrading Paracidovorax sp. BN6-4.
Liang D, Xie Y, Jiang Y, Xu W, Wang Z, Zhang D. Liang D, et al. Water Sci Technol. 2024 Apr;89(8):2006-2019. doi: 10.2166/wst.2024.108. Epub 2024 Apr 2. Water Sci Technol. 2024. PMID: 38678405
First, the hydroxylation of pyridine to form the intermediates pyridin-2(1H)-one and 5,6-dihydropyridine-2,5-diol, the former undergoing oxidative ring opening and the latter oxidative ring opening via N-C2 and C2-C3 ring opening to ammonia and carbon dioxide. Furthermore, …
First, the hydroxylation of pyridine to form the intermediates pyridin-2(1H)-one and 5,6-dihydropyridine-2,5-diol, the former undergoing oxi …
Assessment of anthropogenic pollution in Guanabara Bay (SE Brazil) through biogeochemical data and stable isotope mixing models.
Senez-Mello TM, Martins MVA, de Lima Ferreira PA, Figueira R, Castelo WFL, Damasceno FL, Hohenegger J, Pereira E, Duleba W, Gerardes MC. Senez-Mello TM, et al. Environ Sci Pollut Res Int. 2024 Apr 26. doi: 10.1007/s11356-024-33144-w. Online ahead of print. Environ Sci Pollut Res Int. 2024. PMID: 38671267
Metal concentrations (E) dissolved in water (E(W)), adsorbed by organic matter (E(OM)) and by Mn hydroxides (E(Mn)), and total extracted concentrations (E(T)) were analyzed. Sampling was conducted in 2018 after an oil spill from Reduc Oil Refinery. ...
Metal concentrations (E) dissolved in water (E(W)), adsorbed by organic matter (E(OM)) and by Mn hydroxides (E(Mn)), and total extracted con …
Physiological responses and transcriptomic analysis of StCPD gene overexpression in potato under salt stresses.
Zhou X, Ma Y, Miao R, Li C, Liu Z, Zhang D, Chen S, Luo J, Tang W. Zhou X, et al. Front Plant Sci. 2024 Feb 16;15:1297812. doi: 10.3389/fpls.2024.1297812. eCollection 2024. Front Plant Sci. 2024. PMID: 38434433 Free PMC article.
RESULTS: Results showed the accumulation of 2,4-epibrassionolide (EBL) in T potatoes. We found that under high salt situations, the changed Na(+)/K(+) transporter gene expression was linked with the prevalent ionic responses in T plants, which led to lower concentra …
RESULTS: Results showed the accumulation of 2,4-epibrassionolide (EBL) in T potatoes. We found that under high salt situations, the c …
Eculizumab dose tapering should take into account the nonlinearity of its pharmacokinetics.
Le Tilly O, Gatault P, Semlali S, Sberro-Soussan R, Passot C, Bertrand D, Desvignes C, Caillard S, Paintaud G, Halimi JM, Ternant D. Le Tilly O, et al. Br J Clin Pharmacol. 2024 May;90(5):1312-1321. doi: 10.1111/bcp.16019. Epub 2024 Feb 19. Br J Clin Pharmacol. 2024. PMID: 38373846
METHODS: We analysed 377 eculizumab serum concentrations from 44 patients treated for atypical haemolytic uraemic syndrome and C3 glomerulopathy with a population pharmacokinetic approach. Critical concentrations (below which a non-log-linear decline of concentration over …
METHODS: We analysed 377 eculizumab serum concentrations from 44 patients treated for atypical haemolytic uraemic syndrome and C3 glo …
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis.
Olivero G, Taddeucci A, Vallarino G, Trebesova H, Roggeri A, Gagliani MC, Cortese K, Grilli M, Pittaluga A. Olivero G, et al. Br J Pharmacol. 2024 Jun;181(12):1812-1828. doi: 10.1111/bph.16328. Epub 2024 Feb 18. Br J Pharmacol. 2024. PMID: 38369641
EXPERIMENTAL APPROACH: EAE cortical synaptosomes and gliosomes were analysed for glutamate release efficiency (measured as release of preloaded [(3)H]D-aspartate ([(3)H]D-ASP)), C1q and C3 protein density, and for viability and ongoing apoptosis. KEY RESULTS: In healthy mi …
EXPERIMENTAL APPROACH: EAE cortical synaptosomes and gliosomes were analysed for glutamate release efficiency (measured as release of preloa …
Halogen-Regulated T(c) and X-ray Radiation Detection in 2D Hybrid Perovskite Ferroelastic Semiconductor.
Luo W, Wu LK, Shen HY, Li HK, Xu ZJ, Shi C, Ye HY, Miao LP, Wang N. Luo W, et al. Inorg Chem. 2024 Feb 26;63(8):3913-3920. doi: 10.1021/acs.inorgchem.3c04295. Epub 2024 Feb 15. Inorg Chem. 2024. PMID: 38361417
Herein, we report two 2D hybrid stibium-based halide perovskite (C(3)H(7)N)(3)Sb(2)X(9) (X = Br, 1; Cl, 2) ferroelastic semiconductor possessing dual switching properties of dielectric and second harmonic generation (SHG). Notably, these two hybrids exhibit halogen-regulat …
Herein, we report two 2D hybrid stibium-based halide perovskite (C(3)H(7)N)(3)Sb(2)X(9) (X = Br, 1; Cl, 2) ferroelastic semiconductor …
Imaging geographic atrophy: integrating structure and function to better understand the effects of new treatments.
Vujosevic S, Loewenstein A, O'Toole L, Schmidt-Erfurth UM, Zur D, Chakravarthy U. Vujosevic S, et al. Br J Ophthalmol. 2024 Jan 30:bjo-2023-324246. doi: 10.1136/bjo-2023-324246. Online ahead of print. Br J Ophthalmol. 2024. PMID: 38290804 Review.
This review examined the challenges of clinical trials to date which have sought to treat GA, with particular reference to the successful outcome of C3 complement inhibition. Currently, optical coherence tomography (OCT) seems to be the most suitable method to detect GA an …
This review examined the challenges of clinical trials to date which have sought to treat GA, with particular reference to the successful ou …
SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy.
Lo Cigno I, Calati F, Girone C, Borgogna C, Venuti A, Boldorini R, Gariglio M. Lo Cigno I, et al. Br J Cancer. 2023 Nov;129(11):1863-1874. doi: 10.1038/s41416-023-02465-x. Epub 2023 Oct 14. Br J Cancer. 2023. PMID: 37838812
The enhanced sensitivity to cisplatin as well as p53 restoration were also observed in an in vivo tumorigenicity assay using syngeneic C3.43 cells harbouring an integrated HPV16 genome, injected subcutaneously into C57BL/6J mice. ...
The enhanced sensitivity to cisplatin as well as p53 restoration were also observed in an in vivo tumorigenicity assay using syngeneic C3 …
626 results