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Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun. 2018 Oct 8;9(1):4147. doi: 10.1038/s41467-018-06587-2.
Nat Commun. 2018.
PMID: 30297823
Free PMC article.
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Braffman NR, Piscotta FJ, Hauver J, Campbell EA, Link AJ, Darst SA.
Braffman NR, et al.
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1273-1278. doi: 10.1073/pnas.1817352116. Epub 2019 Jan 9.
Proc Natl Acad Sci U S A. 2019.
PMID: 30626643
Free PMC article.
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The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA.
Lilic M, et al. Among authors: braffman n.
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30423-30432. doi: 10.1073/pnas.2013706117. Epub 2020 Nov 16.
Proc Natl Acad Sci U S A. 2020.
PMID: 33199626
Free PMC article.
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Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis.
Braffman NR, Ruskoski TB, Davis KM, Glasser NR, Johnson C, Okafor CD, Boal AK, Balskus EP.
Braffman NR, et al.
Elife. 2022 Feb 25;11:e75761. doi: 10.7554/eLife.75761.
Elife. 2022.
PMID: 35212625
Free PMC article.
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Biocatalytic Friedel-Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme.
Schultz EE, Braffman NR, Luescher MU, Hager HH, Balskus EP.
Schultz EE, et al. Among authors: braffman nr.
Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3151-3155. doi: 10.1002/anie.201814016. Epub 2019 Feb 14.
Angew Chem Int Ed Engl. 2019.
PMID: 30706984
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Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ(7) -Mesembrenone.
Gan P, Smith MW, Braffman NR, Snyder SA.
Gan P, et al. Among authors: braffman nr.
Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3625-30. doi: 10.1002/anie.201510520. Epub 2016 Feb 10.
Angew Chem Int Ed Engl. 2016.
PMID: 26865400
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