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Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response.
Henriksen-Lacey M, Christensen D, Bramwell VW, Lindenstrøm T, Agger EM, Andersen P, Perrie Y. Henriksen-Lacey M, et al. Among authors: bramwell vw. J Control Release. 2010 Jul 14;145(2):102-8. doi: 10.1016/j.jconrel.2010.03.027. Epub 2010 Apr 8. J Control Release. 2010. PMID: 20381556
Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N',N'-Dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses.
Henriksen-Lacey M, Christensen D, Bramwell VW, Lindenstrøm T, Agger EM, Andersen P, Perrie Y. Henriksen-Lacey M, et al. Among authors: bramwell vw. Mol Pharm. 2011 Feb 7;8(1):153-61. doi: 10.1021/mp100208f. Epub 2010 Dec 15. Mol Pharm. 2011. PMID: 21117621
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