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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. Prokunina-Olsson L, et al. Among authors: brand n. Nat Genet. 2013 Feb;45(2):164-71. doi: 10.1038/ng.2521. Epub 2013 Jan 6. Nat Genet. 2013. PMID: 23291588 Free PMC article.
IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children.
Prokunina-Olsson L, Morrison RD, Obajemu A, Mahamar A, Kim S, Attaher O, Florez-Vargas O, Sidibe Y, Onabajo OO, Hutchinson AA, Manning M, Kwan J, Brand N, Dicko A, Fried M, Albert PS, Mbulaiteye SM, Duffy PE. Prokunina-Olsson L, et al. Among authors: brand n. Genes Immun. 2021 May;22(1):44-55. doi: 10.1038/s41435-021-00127-7. Epub 2021 Apr 13. Genes Immun. 2021. PMID: 33850301 Free PMC article.
191 results