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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.
Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES. Braselmann S, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. doi: 10.1124/jpet.106.109058. Epub 2006 Aug 31. J Pharmacol Exp Ther. 2006. PMID: 16946104 Clinical Trial.
Identification of the Syk kinase inhibitor R112 by a human mast cell screen.
Rossi AB, Herlaar E, Braselmann S, Huynh S, Taylor V, Frances R, Issakani SD, Argade A, Singh R, Payan DG, Masuda ES. Rossi AB, et al. Among authors: braselmann s. J Allergy Clin Immunol. 2006 Sep;118(3):749-55. doi: 10.1016/j.jaci.2006.05.023. Epub 2006 Jul 28. J Allergy Clin Immunol. 2006. PMID: 16950297
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling.
Argade A, Bhamidipati S, Li H, Sylvain C, Clough J, Carroll D, Keim H, Braselmann S, Taylor V, Zhao H, Herlaar E, Issakani SD, Wong BR, Masuda ES, Payan DG, Singh R. Argade A, et al. Among authors: braselmann s. Bioorg Med Chem Lett. 2015;25(10):2122-8. doi: 10.1016/j.bmcl.2015.03.072. Epub 2015 Apr 1. Bioorg Med Chem Lett. 2015. PMID: 25891105
Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy.
Markovtsov V, Duncton MAJ, Bagos A, Yi S, Braselmann S, Bhamidipati S, Darwish IS, Yu J, Owyang AM, Fernandez B, Samant B, Park G, Masuda ES, Shaw SJ. Markovtsov V, et al. Among authors: braselmann s. ACS Med Chem Lett. 2023 Nov 21;14(12):1700-1706. doi: 10.1021/acsmedchemlett.3c00336. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116420
Signalling enzymes: bursting with potential.
Braselmann S, Palmer TM, Cook SJ. Braselmann S, et al. Curr Biol. 1997 Aug 1;7(8):R470-3. doi: 10.1016/s0960-9822(06)00239-9. Curr Biol. 1997. PMID: 9259544 Free article. Review.
12 results