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Year Number of Results
2008 2
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2015 8
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2020 21
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2023 33
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BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism.
Du J, Liu Y, Wu X, Sun J, Shi J, Zhang H, Zheng A, Zhou M, Jiang X. Du J, et al. Nat Commun. 2023 Mar 14;14(1):1413. doi: 10.1038/s41467-023-37116-5. Nat Commun. 2023. PMID: 36918560 Free PMC article.
Despite the hematopoietic origin of osteoclasts, the role of BRD9 in osteoclastogenesis and bone diseases remains unresolved. ...Besides, function specificity of BRD9 distinguished from BRD4 during osteoclastogenesis has been evaluated. ...
Despite the hematopoietic origin of osteoclasts, the role of BRD9 in osteoclastogenesis and bone diseases remains unresolved. ...Besi …
BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma.
Kurata K, Samur MK, Liow P, Wen K, Yamamoto L, Liu J, Morelli E, Gulla A, Tai YT, Qi J, Hideshima T, Anderson KC. Kurata K, et al. Clin Cancer Res. 2023 May 1;29(9):1807-1821. doi: 10.1158/1078-0432.CCR-22-3668. Clin Cancer Res. 2023. PMID: 36780189 Free PMC article.
RESULTS: We found that high BRD9 expression was a poor prognostic factor in multiple myeloma. ...CONCLUSIONS: Our study identifies and validates BRD9 as a novel therapeutic target in preclinical models of multiple myeloma, which provides the framework for the clinic …
RESULTS: We found that high BRD9 expression was a poor prognostic factor in multiple myeloma. ...CONCLUSIONS: Our study identifies an …
Targeting BRD9 for Cancer Treatment: A New Strategy.
Zhu X, Liao Y, Tang L. Zhu X, et al. Onco Targets Ther. 2020 Dec 24;13:13191-13200. doi: 10.2147/OTT.S286867. eCollection 2020. Onco Targets Ther. 2020. PMID: 33380808 Free PMC article. Review.
This review summarizes the potential mechanisms of action of BRD9 in carcinogenesis and the emerging strategies for targeting BRD9 for cancer therapeutics. Although the therapeutic potential of BRD9 has been exploited to some extent, research on the detailed …
This review summarizes the potential mechanisms of action of BRD9 in carcinogenesis and the emerging strategies for targeting BRD9 …
BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.
Xiao M, Kondo S, Nomura M, Kato S, Nishimura K, Zang W, Zhang Y, Akashi T, Viny A, Shigehiro T, Ikawa T, Yamazaki H, Fukumoto M, Tanaka A, Hayashi Y, Koike Y, Aoyama Y, Ito H, Nishikawa H, Kitamura T, Kanai A, Yokoyama A, Fujiwara T, Goyama S, Noguchi H, Lee SC, Toyoda A, Hinohara K, Abdel-Wahab O, Inoue D. Xiao M, et al. Nat Commun. 2023 Dec 15;14(1):8372. doi: 10.1038/s41467-023-44081-6. Nat Commun. 2023. PMID: 38102116 Free PMC article.
BRD9 loss enhances chromatin accessibility, promoting myeloid lineage skewing while impairing B cell development. BRD9 significantly colocalizes with CTCF, whose chromatin recruitment is augmented by BRD9 loss, leading to altered chromatin state and expressio …
BRD9 loss enhances chromatin accessibility, promoting myeloid lineage skewing while impairing B cell development. BRD9 signifi …
Aberrant activation of m6A demethylase FTO renders HIF2alpha(low/-) clear cell renal cell carcinoma sensitive to BRD9 inhibitors.
Zhang C, Chen L, Lou W, Su J, Huang J, Liu A, Xu Y, He H, Gao Y, Xu D, Li Q. Zhang C, et al. Sci Transl Med. 2021 Sep 29;13(613):eabf6045. doi: 10.1126/scitranslmed.abf6045. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586831
BRD9 knockdown or the BRD9-selective antagonist I-BRD9 suppressed the growth of HIF2alpha(low/) but not HIF2alpha(high) ccRCC cells in vitro. ...Together, these findings indicate that BRD9 is a druggable target for treating HIF2alpha(low/) ccRCC....
BRD9 knockdown or the BRD9-selective antagonist I-BRD9 suppressed the growth of HIF2alpha(low/) but not HIF2alpha(high) …
BRD9-mediated control of the TGF-beta/Activin/Nodal pathway regulates self-renewal and differentiation of human embryonic stem cells and progression of cancer cells.
Wang X, Song C, Ye Y, Gu Y, Li X, Chen P, Leng D, Xiao J, Wu H, Xie S, Liu W, Zhao Q, Chen D, Chen X, Wu Q, Chen G, Zhang W. Wang X, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11634-11651. doi: 10.1093/nar/gkad907. Nucleic Acids Res. 2023. PMID: 37870468 Free PMC article.
Here, we demonstrate that impaired BRD9 function reduces the self-renewal capacity of hESCs and alters their differentiation potential. Specifically, BRD9 depletion inhibits meso-endoderm differentiation while promoting neural ectoderm differentiation. ...
Here, we demonstrate that impaired BRD9 function reduces the self-renewal capacity of hESCs and alters their differentiation potentia …
BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma.
Weisberg E, Chowdhury B, Meng C, Case AE, Ni W, Garg S, Sattler M, Azab AK, Sun J, Muz B, Sanchez D, Toure A, Stone RM, Galinsky I, Winer E, Gleim S, Gkountela S, Kedves A, Harrington E, Abrams T, Zoller T, Vaupel A, Manley P, Faller M, Chung B, Chen X, Busenhart P, Stephan C, Calkins K, Bonenfant D, Thoma CR, Forrester W, Griffin JD. Weisberg E, et al. Blood Cancer J. 2022 Jul 19;12(7):110. doi: 10.1038/s41408-022-00704-7. Blood Cancer J. 2022. PMID: 35853853 Free PMC article.
Following depletion of BRD9 protein, AML cells undergo terminal differentiation, whereas apoptosis was more prominent in ALL and MM. ...Degradation of BRD9 potentiated the effects of several chemotherapeutic agents and targeted therapies against AML, ALL, and MM. .. …
Following depletion of BRD9 protein, AML cells undergo terminal differentiation, whereas apoptosis was more prominent in ALL and MM. …
BRD9 Bifunctional Degraders for Treating Cancer.
Sabnis RW. Sabnis RW. ACS Med Chem Lett. 2021 Nov 6;12(12):1879-1880. doi: 10.1021/acsmedchemlett.1c00580. eCollection 2021 Dec 9. ACS Med Chem Lett. 2021. PMID: 34917243 Free PMC article. No abstract available.
BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4.
Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. Ahmed NS, et al. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2110812119. doi: 10.1073/pnas.2110812119. Proc Natl Acad Sci U S A. 2022. PMID: 34983841 Free PMC article.
BRD9-dependent genes overlapped highly with a subset of genes differentially regulated by BET protein inhibition with JQ1 following endotoxin stimulation. ...In the presence of BRD9i or dBRD9, STAT1-, STAT2-, and IRF9-binding is reduced, in some cases with reduced binding …
BRD9-dependent genes overlapped highly with a subset of genes differentially regulated by BET protein inhibition with JQ1 following e …
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming.
Sevinç K, Sevinç GG, Cavga AD, Philpott M, Kelekçi S, Can H, Cribbs AP, Yıldız AB, Yılmaz A, Ayar ES, Arabacı DH, Dunford JE, Ata D, Sigua LH, Qi J, Oppermann U, Onder TT. Sevinç K, et al. Stem Cell Reports. 2022 Dec 13;17(12):2629-2642. doi: 10.1016/j.stemcr.2022.10.005. Epub 2022 Nov 3. Stem Cell Reports. 2022. PMID: 36332631 Free PMC article.
We find that BRD9 is dispensable for human induced pluripotent stem cells under primed but not under naive conditions. ...BRD9 maintains the expression of transcriptional regulators MN1 and ZBTB38, both of which impede reprogramming. ...
We find that BRD9 is dispensable for human induced pluripotent stem cells under primed but not under naive conditions. ...BRD9 …
150 results