Breitenbucher JG - Search Results

1

Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator.

Mackman RL, Katz BA, Breitenbucher JG, Hui HC, Verner E, Luong C, Liu L, Sprengeler PA. Mackman RL, et al. Among authors: breitenbucher jg. J Med Chem. 2001 Nov 8;44(23):3856-71. doi: 10.1021/jm010244+. J Med Chem. 2001. PMID: 11689072

2

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.

Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Katz BA, et al. Among authors: breitenbucher jg. Chem Biol. 2001 Nov;8(11):1107-21. doi: 10.1016/s1074-5521(01)00084-9. Chem Biol. 2001. PMID: 11731301

3

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J. Mackman RL, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6. Bioorg Med Chem Lett. 2002. PMID: 12113832

4

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW. Katz BA, et al. Among authors: breitenbucher jg. J Mol Biol. 2003 May 23;329(1):93-120. doi: 10.1016/s0022-2836(03)00399-1. J Mol Biol. 2003. PMID: 12742021

5

Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles.

Arienti KL, Brunmark A, Axe FU, McClure K, Lee A, Blevitt J, Neff DK, Huang L, Crawford S, Pandit CR, Karlsson L, Breitenbucher JG. Arienti KL, et al. Among authors: breitenbucher jg. J Med Chem. 2005 Mar 24;48(6):1873-85. doi: 10.1021/jm0495935. J Med Chem. 2005. PMID: 15771432

6

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.

Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Romero FA, et al. Among authors: breitenbucher jg. J Med Chem. 2007 Mar 8;50(5):1058-68. doi: 10.1021/jm0611509. Epub 2007 Feb 6. J Med Chem. 2007. PMID: 17279740 Free PMC article.

7

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.

Seierstad M, Breitenbucher JG. Seierstad M, et al. Among authors: breitenbucher jg. J Med Chem. 2008 Dec 11;51(23):7327-43. doi: 10.1021/jm800311k. J Med Chem. 2008. PMID: 18983142 Review. No abstract available.

8

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.

Dyck B, Branstetter B, Gharbaoui T, Hudson AR, Breitenbucher JG, Gomez L, Botrous I, Marrone T, Barido R, Allerston CK, Cedervall EP, Xu R, Sridhar V, Barker R, Aertgeerts K, Schmelzer K, Neul D, Lee D, Massari ME, Andersen CB, Sebring K, Zhou X, Petroski R, Limberis J, Augustin M, Chun LE, Edwards TE, Peters M, Tabatabaei A. Dyck B, et al. Among authors: breitenbucher jg. J Med Chem. 2017 Apr 27;60(8):3472-3483. doi: 10.1021/acs.jmedchem.7b00302. Epub 2017 Apr 13. J Med Chem. 2017. PMID: 28406621

9

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.

Gomez L, Hack MD, McClure K, Sehon C, Huang L, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. Gomez L, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6493-8. doi: 10.1016/j.bmcl.2007.09.093. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933530

10

Novel non-benzimidazole chk2 kinase inhibitors.

McClure KJ, Huang L, Arienti KL, Axe FU, Brunmark A, Blevitt J, Breitenbucher JG. McClure KJ, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1924-8. doi: 10.1016/j.bmcl.2005.12.096. Epub 2006 Jan 25. Bioorg Med Chem Lett. 2006. PMID: 16442290

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