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The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress.
Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V. Testai L, et al. Among authors: breschi mc. Pharmacol Res. 2016 Nov;113(Pt A):290-299. doi: 10.1016/j.phrs.2016.09.006. Epub 2016 Sep 9. Pharmacol Res. 2016. PMID: 27616550
Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.
Testai L, Barrese V, Soldovieri MV, Ambrosino P, Martelli A, Vinciguerra I, Miceli F, Greenwood IA, Curtis MJ, Breschi MC, Sisalli MJ, Scorziello A, Canduela MJ, Grandes P, Calderone V, Taglialatela M. Testai L, et al. Among authors: breschi mc. Cardiovasc Res. 2016 May 1;110(1):40-50. doi: 10.1093/cvr/cvv281. Epub 2015 Dec 29. Cardiovasc Res. 2016. PMID: 26718475
The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.
Martelli A, Testai L, Anzini M, Cappelli A, Di Capua A, Biava M, Poce G, Consalvi S, Giordani A, Caselli G, Rovati L, Ghelardini C, Patrignani P, Sautebin L, Breschi MC, Calderone V. Martelli A, et al. Among authors: breschi mc. Pharmacol Res. 2013 Dec;78:1-9. doi: 10.1016/j.phrs.2013.09.008. Epub 2013 Sep 29. Pharmacol Res. 2013. PMID: 24083950
139 results