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Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
Szczepańska K, Pockes S, Podlewska S, Höring C, Mika K, Latacz G, Bednarski M, Siwek A, Karcz T, Nagl M, Bresinsky M, Mönnich D, Seibel U, Kuder KJ, Kotańska M, Stark H, Elz S, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: bresinsky m. Eur J Med Chem. 2021 Mar 5;213:113041. doi: 10.1016/j.ejmech.2020.113041. Epub 2020 Nov 24. Eur J Med Chem. 2021. PMID: 33261900
Cardiac Effects of Novel Histamine H2 Receptor Agonists.
Gergs U, Büxel ML, Bresinsky M, Kirchhefer U, Fehse C, Höring C, Hofmann B, Marušáková M, Čináková A, Schwarz R, Pockes S, Neumann J. Gergs U, et al. Among authors: bresinsky m. J Pharmacol Exp Ther. 2021 Nov;379(3):223-234. doi: 10.1124/jpet.121.000822. Epub 2021 Sep 17. J Pharmacol Exp Ther. 2021. PMID: 34535565
Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Bresinsky M, Strasser JM, Vallaster B, Liu P, McCue WM, Fuller J, Hubmann A, Singh G, Nelson KM, Cuellar ME, Wilmot CM, Finzel BC, Ashe KH, Walters MA, Pockes S. Bresinsky M, et al. ACS Pharmacol Transl Sci. 2022 Jan 5;5(1):20-40. doi: 10.1021/acsptsci.1c00251. eCollection 2022 Jan 14. ACS Pharmacol Transl Sci. 2022. PMID: 35059567 Free PMC article.
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
Singh G, Liu P, Yao KR, Strasser JM, Hlynialuk C, Leinonen-Wright K, Teravskis PJ, Choquette JM, Ikramuddin J, Bresinsky M, Nelson KM, Liao D, Ashe KH, Walters MA, Pockes S. Singh G, et al. Among authors: bresinsky m. ACS Chem Neurosci. 2022 May 18;13(10):1549-1557. doi: 10.1021/acschemneuro.2c00100. Epub 2022 May 6. ACS Chem Neurosci. 2022. PMID: 35522720 Free PMC article.
11 results