Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats.
Elmore JS, Dillon-Carter O, Partilla JS, Ellefsen KN, Concheiro M, Suzuki M, Rice KC, Huestis MA, Baumann MH.
Elmore JS, et al.
Neuropsychopharmacology. 2017 Feb;42(3):649-660. doi: 10.1038/npp.2016.213. Epub 2016 Sep 23.
Neuropsychopharmacology. 2017.
PMID: 27658484
Free PMC article.
Methylone, MDC, and HHMC were substrate-type releasers at monoamine transporters as determined in vitro, but only methylone and MDC (1, 3 mg/kg, iv) produced significant elevations in brain extracellular dopamine and 5-HT in vivo. Our findings demonstrate that methylone is …
Methylone, MDC, and HHMC were substrate-type releasers at monoamine transporters as determined in vitro, but only methylone and MDC (1, 3 mg …