Brinkman EK - Search Results

1

Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles.

Geng K, Merino LG, Veiga RG, Sommerauer C, Epperlein J, Brinkman EK, Kutter C. Geng K, et al. Among authors: brinkman ek. Life Sci Alliance. 2023 Nov 20;7(2):e202302128. doi: 10.26508/lsa.202302128. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 37984988 Free PMC article.

2

Protocol: A Multiplexed Reporter Assay to Study Effects of Chromatin Context on DNA Double-Strand Break Repair.

Schep R, Leemans C, Brinkman EK, van Schaik T, van Steensel B. Schep R, et al. Among authors: brinkman ek. Front Genet. 2022 Jan 31;12:785947. doi: 10.3389/fgene.2021.785947. eCollection 2021. Front Genet. 2022. PMID: 35173762 Free PMC article.

3

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.

Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B. Schep R, et al. Among authors: brinkman ek. Mol Cell. 2021 May 20;81(10):2216-2230.e10. doi: 10.1016/j.molcel.2021.03.032. Epub 2021 Apr 12. Mol Cell. 2021. PMID: 33848455 Free PMC article.

4

Rapid Quantitative Evaluation of CRISPR Genome Editing by TIDE and TIDER.

Brinkman EK, van Steensel B. Brinkman EK, et al. Methods Mol Biol. 2019;1961:29-44. doi: 10.1007/978-1-4939-9170-9_3. Methods Mol Biol. 2019. PMID: 30912038

5

Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler.

Chen Y, Zhang Y, Wang Y, Zhang L, Brinkman EK, Adam SA, Goldman R, van Steensel B, Ma J, Belmont AS. Chen Y, et al. Among authors: brinkman ek. J Cell Biol. 2018 Nov 5;217(11):4025-4048. doi: 10.1083/jcb.201807108. Epub 2018 Aug 28. J Cell Biol. 2018. PMID: 30154186 Free PMC article.

6

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks.

Brinkman EK, Chen T, de Haas M, Holland HA, Akhtar W, van Steensel B. Brinkman EK, et al. Mol Cell. 2018 Jun 7;70(5):801-813.e6. doi: 10.1016/j.molcel.2018.04.016. Epub 2018 May 24. Mol Cell. 2018. PMID: 29804829 Free PMC article.

7

Easy quantification of template-directed CRISPR/Cas9 editing.

Brinkman EK, Kousholt AN, Harmsen T, Leemans C, Chen T, Jonkers J, van Steensel B. Brinkman EK, et al. Nucleic Acids Res. 2018 Jun 1;46(10):e58. doi: 10.1093/nar/gky164. Nucleic Acids Res. 2018. PMID: 29538768 Free PMC article.

8

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.

Janssen A, Breuer GA, Brinkman EK, van der Meulen AI, Borden SV, van Steensel B, Bindra RS, LaRocque JR, Karpen GH. Janssen A, et al. Among authors: brinkman ek. Genes Dev. 2016 Jul 15;30(14):1645-57. doi: 10.1101/gad.283028.116. Genes Dev. 2016. PMID: 27474442 Free PMC article.

9

Easy quantitative assessment of genome editing by sequence trace decomposition.

Brinkman EK, Chen T, Amendola M, van Steensel B. Brinkman EK, et al. Nucleic Acids Res. 2014 Dec 16;42(22):e168. doi: 10.1093/nar/gku936. Epub 2014 Oct 9. Nucleic Acids Res. 2014. PMID: 25300484 Free PMC article.

10

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.

Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. Warmerdam DO, et al. Among authors: brinkman ek. J Cell Sci. 2013 May 1;126(Pt 9):1923-30. doi: 10.1242/jcs.118265. Epub 2013 Feb 27. J Cell Sci. 2013. PMID: 23447674 Free article.

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