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Page 1
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
Mardilovich K, Baugh M, Crighton D, Kowalczyk D, Gabrielsen M, Munro J, Croft DR, Lourenco F, James D, Kalna G, McGarry L, Rath O, Shanks E, Garnett MJ, McDermott U, Brookfield J, Charles M, Hammonds T, Olson MF. Mardilovich K, et al. Among authors: brookfield j. Oncotarget. 2015 Nov 17;6(36):38469-86. doi: 10.18632/oncotarget.6288. Oncotarget. 2015. PMID: 26540348 Free PMC article.
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles M, Cheasty A, Critchlow SE, Culshaw J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson M, McCarron H, McKelvie J, Mooney L, Nissink JWM, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt JJ, Wood JM, Wrigley GL, Yu G, Zhang P. Finlay MRV, et al. Among authors: brookfield j. J Med Chem. 2019 Jul 25;62(14):6540-6560. doi: 10.1021/acs.jmedchem.9b00260. Epub 2019 Jul 16. J Med Chem. 2019. PMID: 31199640
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, Degorce SL, Donald C, Evans NJ, Groombridge S, Hopcroft P, Jones NP, Kettle JG, Lamont S, Lewis HJ, MacFaull P, McLoughlin SB, Rigoreau LJ, Smith JM, St-Gallay S, Stock JK, Turnbull AP, Wheatley ER, Winter J, Wingfield J. Boyd S, et al. Among authors: brookfield jl. J Med Chem. 2015 Apr 23;58(8):3611-25. doi: 10.1021/acs.jmedchem.5b00352. Epub 2015 Apr 13. J Med Chem. 2015. PMID: 25849762
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Bailey N, Bamford MJ, Brissy D, Brookfield J, Demont E, Elliott R, Garton N, Farre-Gutierrez I, Hayhow T, Hutley G, Naylor A, Panchal TA, Seow HX, Spalding D, Takle AK. Bailey N, et al. Among authors: brookfield j. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. doi: 10.1016/j.bmcl.2009.04.127. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19467868
Selective Hydroxylation of C(sp3 )-H Bonds in Steroids.
Abas H, Blencowe P, Brookfield JL, Harwood LA. Abas H, et al. Among authors: brookfield jl. Chemistry. 2023 Aug 4;29(44):e202301066. doi: 10.1002/chem.202301066. Epub 2023 Jul 12. Chemistry. 2023. PMID: 37235530 Review.
Correction to "Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models".
Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles M, Cheasty A, Critchlow SE, Culshaw J, Debreczeni J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson M, McCarron H, McKelvie J, Mooney L, Nissink JWM, Patel J, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt JJ, Wood JM, Wrigley GL, Yu G, Zhang P. Finlay MRV, et al. Among authors: brookfield j. J Med Chem. 2023 Jul 13;66(13):9223-9224. doi: 10.1021/acs.jmedchem.3c00198. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37341555 No abstract available.
135 results