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The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.
Yasuno F, Brown AK, Zoghbi SS, Krushinski JH, Chernet E, Tauscher J, Schaus JM, Phebus LA, Chesterfield AK, Felder CC, Gladding RL, Hong J, Halldin C, Pike VW, Innis RB. Yasuno F, et al. Among authors: brown ak. Neuropsychopharmacology. 2008 Jan;33(2):259-69. doi: 10.1038/sj.npp.1301402. Epub 2007 Mar 28. Neuropsychopharmacology. 2008. PMID: 17392732
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.
Siméon FG, Brown AK, Zoghbi SS, Patterson VM, Innis RB, Pike VW. Siméon FG, et al. Among authors: brown ak. J Med Chem. 2007 Jul 12;50(14):3256-66. doi: 10.1021/jm0701268. Epub 2007 Jun 16. J Med Chem. 2007. PMID: 17571866
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.
Cai L, Liow JS, Zoghbi SS, Cuevas J, Baetas C, Hong J, Shetty HU, Seneca NM, Brown AK, Gladding R, Temme SS, Herman MM, Innis RB, Pike VW. Cai L, et al. Among authors: brown ak. J Med Chem. 2008 Jan 10;51(1):148-58. doi: 10.1021/jm700970s. Epub 2007 Dec 14. J Med Chem. 2008. PMID: 18078311
293 results