Brown P - Search Results

1

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.

Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. Matheny CJ, et al. Among authors: brown p. Chem Biol. 2013 Nov 21;20(11):1352-63. doi: 10.1016/j.chembiol.2013.09.014. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183972 Free PMC article.

2

IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples.

Piloto O, Nguyen B, Huso D, Kim KT, Li Y, Witte L, Hicklin DJ, Brown P, Small D. Piloto O, et al. Among authors: brown p. Cancer Res. 2006 May 1;66(9):4843-51. doi: 10.1158/0008-5472.CAN-06-0018. Cancer Res. 2006. PMID: 16651440

3

Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways.

Piloto O, Wright M, Brown P, Kim KT, Levis M, Small D. Piloto O, et al. Among authors: brown p. Blood. 2007 Feb 15;109(4):1643-52. doi: 10.1182/blood-2006-05-023804. Epub 2006 Oct 17. Blood. 2007. PMID: 17047150 Free PMC article.

4

Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.

Rau R, Brown P. Rau R, et al. Among authors: brown p. Hematol Oncol. 2009 Dec;27(4):171-81. doi: 10.1002/hon.904. Hematol Oncol. 2009. PMID: 19569254 Free PMC article. Review.

5

MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism.

Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P. Sison EA, et al. Among authors: brown p. Br J Haematol. 2013 Mar;160(6):785-97. doi: 10.1111/bjh.12205. Epub 2013 Jan 7. Br J Haematol. 2013. PMID: 23294096 Free PMC article.

6

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield AS, Huso D, McIntyre E, Clohessy JG, Reschke M, Pandolfi PP, Small D, Brown P. Rau R, et al. Among authors: brown p. Exp Hematol. 2014 Feb;42(2):101-13.e5. doi: 10.1016/j.exphem.2013.10.005. Epub 2013 Oct 29. Exp Hematol. 2014. PMID: 24184354 Free PMC article.

7

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition.

Sison EA, Magoon D, Li L, Annesley CE, Rau RE, Small D, Brown P. Sison EA, et al. Among authors: brown p. Oncotarget. 2014 Oct 15;5(19):8947-58. doi: 10.18632/oncotarget.2407. Oncotarget. 2014. PMID: 25333254 Free PMC article.

8

Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice.

Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DM, Brown P. Annesley CE, et al. Among authors: brown p. Oncotarget. 2018 Oct 19;9(82):35313-35326. doi: 10.18632/oncotarget.26238. eCollection 2018 Oct 19. Oncotarget. 2018. PMID: 30450160 Free PMC article.

9

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization.

Narang S, Evensen NA, Saliba J, Pierro J, Loh ML, Brown PA, Kolekar P, Mulder H, Shao Y, Easton J, Ma X, Tsirigos A, Carroll WL. Narang S, et al. Among authors: brown pa. Genome Biol. 2023 Apr 4;24(1):64. doi: 10.1186/s13059-023-02905-0. Genome Biol. 2023. PMID: 37016431 Free PMC article.

10

FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells.

Zheng R, Levis M, Piloto O, Brown P, Baldwin BR, Gorin NC, Beran M, Zhu Z, Ludwig D, Hicklin D, Witte L, Li Y, Small D. Zheng R, et al. Among authors: brown p. Blood. 2004 Jan 1;103(1):267-74. doi: 10.1182/blood-2003-06-1969. Epub 2003 Sep 11. Blood. 2004. PMID: 12969963 Free article.

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