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Page 1
BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.
Xu R, Wang K, Yao Z, Zhang Y, Jin L, Pang J, Zhou Y, Wang K, Liu D, Zhang Y, Sun P, Wang F, Chang X, Liu T, Wang S, Zhang Y, Lin S, Hu C, Zhu Y, Han X. Xu R, et al. J Mol Cell Biol. 2023 Nov 27;15(5):mjad033. doi: 10.1093/jmcb/mjad033. J Mol Cell Biol. 2023. PMID: 37188647 Free PMC article.
Brain-specific serine/threonine-protein kinase 2 (BRSK2) plays critical roles in insulin secretion and beta-cell biology. However, whether BRSK2 is associated with human type 2 diabetes mellitus (T2DM) has not been determined. ...
Brain-specific serine/threonine-protein kinase 2 (BRSK2) plays critical roles in insulin secretion and beta-cell biology. However, wh …
Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.
Hiatt SM, Thompson ML, Prokop JW, Lawlor JMJ, Gray DE, Bebin EM, Rinne T, Kempers M, Pfundt R, van Bon BW, Mignot C, Nava C, Depienne C, Kalsner L, Rauch A, Joset P, Bachmann-Gagescu R, Wentzensen IM, McWalter K, Cooper GM. Hiatt SM, et al. Am J Hum Genet. 2019 Apr 4;104(4):701-708. doi: 10.1016/j.ajhg.2019.02.002. Epub 2019 Mar 14. Am J Hum Genet. 2019. PMID: 30879638 Free PMC article.
We also find that exome sequencing provides lower coverage and appears less sensitive to rare variation in BRSK2 than does genome sequencing; this fact most likely reduces BRSK2's visibility in many clinical and research sequencing efforts. Altogether, our results i …
We also find that exome sequencing provides lower coverage and appears less sensitive to rare variation in BRSK2 than does genome seq …
BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.
Wang Y, Wan B, Zhou J, Li R, Yu L. Wang Y, et al. Biotechnol Lett. 2013 Dec;35(12):1983-9. doi: 10.1007/s10529-013-1295-2. Epub 2013 Aug 2. Biotechnol Lett. 2013. PMID: 23907667
Immunofluorescence demonstrated that BRSK2 and VCP/p97 were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta, a substrate in ERAD for VCP/p97. Thus, BRSK2 might affect the activity of VCP/p97 in ERAD....
Immunofluorescence demonstrated that BRSK2 and VCP/p97 were co-localized and also that knockdown of endogenous BRSK2 induced i …
BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.
Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y, Yu L. Guo Z, et al. Biochem Biophys Res Commun. 2006 Sep 8;347(4):867-71. doi: 10.1016/j.bbrc.2006.06.178. Epub 2006 Jul 25. Biochem Biophys Res Commun. 2006. PMID: 16870137
Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase o …
Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRS …
BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
Wang Y, Wan B, Li D, Zhou J, Li R, Bai M, Chen F, Yu L. Wang Y, et al. Biochem Biophys Res Commun. 2012 Jul 13;423(4):813-8. doi: 10.1016/j.bbrc.2012.06.046. Epub 2012 Jun 16. Biochem Biophys Res Commun. 2012. PMID: 22713462
Furthermore, we also observed that ER stress induces endogenous BRSK2 to localize to the ER. Importantly, knockdown of endogenous BRSK2 expression enhances ER stress-mediated apoptosis in cells while over express BRSK2 in wild type or kinase-dead type both re …
Furthermore, we also observed that ER stress induces endogenous BRSK2 to localize to the ER. Importantly, knockdown of endogenous …
Dynamic Regulation of brsk2 in the Social and Motor Development of Zebrafish: A Developmental Behavior Analysis.
Deng J, Liu C, Hu M, Hu C, Lin J, Li Q, Xu X. Deng J, et al. Int J Mol Sci. 2023 Nov 19;24(22):16506. doi: 10.3390/ijms242216506. Int J Mol Sci. 2023. PMID: 38003696 Free PMC article.
However, little is known about the dynamic analysis of social and motor development at multiple time points during the development of the brsk2 gene. We generated a novel brsk2-deficient (brsk2ab(-/-)) zebrafish model through CRISPR/Cas9 editing and conducted compre …
However, little is known about the dynamic analysis of social and motor development at multiple time points during the development of the …
BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
Saiyin H, Na N, Han X, Fang Y, Wu Y, Lou W, Yang X. Saiyin H, et al. Oncotarget. 2017 Jul 4;8(27):44669-44681. doi: 10.18632/oncotarget.17965. Oncotarget. 2017. PMID: 28591720 Free PMC article.
This implied that PDAC cells might harbor an intrinsic merit that strengthens Akt activity. Here we showed that BRSK2, a serine/threonine-protein kinase of AMPK family, was induced by nutrient deprivation in PDAC cells and suppressed mTORC1 activity via phosphorylation of …
This implied that PDAC cells might harbor an intrinsic merit that strengthens Akt activity. Here we showed that BRSK2, a serine/threo …
Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells.
Chen XY, Gu XT, Saiyin H, Wan B, Zhang YJ, Li J, Wang YL, Gao R, Wang YF, Dong WP, Najjar SM, Zhang CY, Ding HF, Liu JO, Yu L. Chen XY, et al. J Biol Chem. 2012 Aug 31;287(36):30368-75. doi: 10.1074/jbc.M112.375618. Epub 2012 Jul 13. J Biol Chem. 2012. PMID: 22798068 Free PMC article. Clinical Trial.
Brain-selective kinase 2 (BRSK2) has been shown to play an essential role in neuronal polarization. ...Conversely, knockdown of BRSK2 by siRNA increases serum insulin levels in mice. Our results reveal a novel function of BRSK2 in the regulation of GSIS in be …
Brain-selective kinase 2 (BRSK2) has been shown to play an essential role in neuronal polarization. ...Conversely, knockdown of BR …
APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.
Li R, Wan B, Zhou J, Wang Y, Luo T, Gu X, Chen F, Yu L. Li R, et al. PLoS One. 2012;7(9):e45932. doi: 10.1371/journal.pone.0045932. Epub 2012 Sep 21. PLoS One. 2012. PMID: 23029325 Free PMC article.
However, the regulatory mechanisms and exact biological function of BRSK2 remain unclear. Herein, we show that BRSK2 co-localizes with the centrosomes during mitosis. ...Additionally, overexpression of either BRSK2(WT) or BRSK2(deltaKEN) increases the …
However, the regulatory mechanisms and exact biological function of BRSK2 remain unclear. Herein, we show that BRSK2 co-locali …
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor.
Tamir TY, Bowman BM, Agajanian MJ, Goldfarb D, Schrank TP, Stohrer T, Hale AE, Siesser PF, Weir SJ, Murphy RM, LaPak KM, Weissman BE, Moorman NJ, Major MB. Tamir TY, et al. J Cell Sci. 2020 Jul 15;133(14):jcs241356. doi: 10.1242/jcs.241356. J Cell Sci. 2020. PMID: 32546533 Free PMC article.
As a result, BRSK2 kinase activation suppresses ribosome-RNA complexes, global protein synthesis and NRF2 protein levels. Collectively, our data illuminate the BRSK2 and BRSK1 kinases, in part by functionally connecting them to NRF2 signaling and mTOR. ...
As a result, BRSK2 kinase activation suppresses ribosome-RNA complexes, global protein synthesis and NRF2 protein levels. Collectivel …
68 results