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Theoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor V.
Biophys J. 2004 Jan;86(1 Pt 1):488-98. doi: 10.1016/S0006-3495(04)74127-2.
Biophys J. 2004.
PMID: 14695293
Free PMC article.
Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
Castoldi E, Brugge JM, Nicolaes GA, Girelli D, Tans G, Rosing J.
Castoldi E, et al. Among authors: brugge jm.
Blood. 2004 Jun 1;103(11):4173-9. doi: 10.1182/blood-2003-10-3578. Epub 2004 Feb 19.
Blood. 2004.
PMID: 14976057
Free article.
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Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation.
Brugge JM, Simioni P, Bernardi F, Tormene D, Lunghi B, Tans G, Pagnan A, Rosing J, Castoldi E.
Brugge JM, et al.
J Thromb Haemost. 2005 Dec;3(12):2695-702. doi: 10.1111/j.1538-7836.2005.01634.x.
J Thromb Haemost. 2005.
PMID: 16359508
Free article.
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Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels.
Brugge JM, Tans G, Rosing J, Castoldi E.
Brugge JM, et al.
Thromb Haemost. 2006 Feb;95(2):236-42. doi: 10.1160/TH05-08-0582.
Thromb Haemost. 2006.
PMID: 16493484
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