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Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis (HCMBL).
Kleinstern G, Boddicker NJ, O'Brien DR, Allmer C, Rabe KG, Norman AD, Griffin R, Yan H, Ma T, Call TG, Bruins L, Brown S, Bonolo de Campos C, Hanson CA, Leis JF, Ding W, Vachon CM, Kay NE, Oakes CC, Parker A, Brander DM, Weinberg JB, Furman RR, Shanafelt TD, Cerhan JR, Parikh SA, Braggio E, Slager SL. Kleinstern G, et al. Among authors: bruins l. Blood Adv. 2024 Feb 15;8(9):2118-29. doi: 10.1182/bloodadvances.2023012242. Online ahead of print. Blood Adv. 2024. PMID: 38359367 Free PMC article.
Differential prognosis of single and multiple TP53 abnormalities in high-count MBL and untreated CLL.
Griffin R, Wiedmeier-Nutor JE, Parikh SA, McCabe CE, O'Brien DR, Boddicker NJ, Kleinstern G, Rabe KG, Bruins L, Brown S, Bonolo de Campos C, Ding W, Leis JF, Hampel PJ, Call TG, Van Dyke DL, Kay NE, Cerhan JR, Yan H, Slager SL, Braggio E. Griffin R, et al. Among authors: bruins l. Blood Adv. 2023 Jul 11;7(13):3169-3179. doi: 10.1182/bloodadvances.2022009040. Blood Adv. 2023. PMID: 36877634 Free PMC article.
Transcriptional profiles define drug refractory disease in myeloma.
Zhu YX, Bruins LA, Chen X, Shi CX, Bonolo De Campos C, Meurice N, Wang X, Ahmann GJ, Ramsower CA, Braggio E, Rimsza LM, Stewart AK. Zhu YX, et al. Among authors: bruins la. EJHaem. 2022 May 9;3(3):804-814. doi: 10.1002/jha2.455. eCollection 2022 Aug. EJHaem. 2022. PMID: 36051067 Free PMC article.
"Direct to Drug" screening as a precision medicine tool in multiple myeloma.
Bonolo de Campos C, Meurice N, Petit JL, Polito AN, Zhu YX, Wang P, Bruins LA, Wang X, Lopez Armenta ID, Darvish SA, Ahmann GJ, Henderson KJ, Tian S, Kruse JJ, Stewart WM, Larsen JT, Reeder CB, Dingli D, Kapoor P, Kumar SK, Fonseca R, Bergsagel PL, Braggio E, Stewart AK. Bonolo de Campos C, et al. Among authors: bruins la. Blood Cancer J. 2020 May 11;10(5):54. doi: 10.1038/s41408-020-0320-7. Blood Cancer J. 2020. PMID: 32393731 Free PMC article.
Tumor mutational load predicts time to first treatment in chronic lymphocytic leukemia (CLL) and monoclonal B-cell lymphocytosis beyond the CLL international prognostic index.
Kleinstern G, O'Brien DR, Li X, Tian S, Kabat BF, Rabe KG, Norman AD, Yan H, Vachon CM, Boddicker NJ, Call TG, Parikh SA, Bruins L, Bonolo de Campos C, Leis JF, Shanafelt TD, Ding W, Cerhan JR, Kay NE, Slager SL, Braggio E. Kleinstern G, et al. Among authors: bruins l. Am J Hematol. 2020 Aug;95(8):906-917. doi: 10.1002/ajh.25831. Epub 2020 May 7. Am J Hematol. 2020. PMID: 32279347 Free PMC article.
Identification of PIKfyve kinase as a target in multiple myeloma.
de Campos CB, Zhu YX, Sepetov N, Romanov S, Bruins LA, Shi CX, Stein CK, Petit JL, Polito AN, Sharik ME, Meermeier EW, Ahmann GJ, Armenta IDL, Kruse J, Bergsagel PL, Chesi M, Meurice N, Braggio E, Stewart AK. de Campos CB, et al. Among authors: bruins la. Haematologica. 2020 Jun;105(6):1641-1649. doi: 10.3324/haematol.2019.222729. Epub 2019 Oct 3. Haematologica. 2020. PMID: 31582538 Free PMC article.
IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.
Barrio S, Munawar U, Zhu YX, Giesen N, Shi CX, Viá MD, Sanchez R, Bruins L, Demler T, Müller N, Haertle L, Garitano A, Steinbrunn T, Danhof S, Cuenca I, Barrio-Garcia C, Braggio E, Rosenwald A, Martinez-Lopez J, Rasche L, Raab MS, Stewart AK, Einsele H, Stühmer T, Kortüm KM. Barrio S, et al. Among authors: bruins l. Haematologica. 2020 May;105(5):e237-e241. doi: 10.3324/haematol.2019.217943. Epub 2019 Sep 26. Haematologica. 2020. PMID: 31558666 Free PMC article. No abstract available.
25 results