Brunton VG - Search Results

1

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A. Fraser C, et al. Among authors: brunton vg. J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4. J Med Chem. 2016. PMID: 27115835 Free PMC article.

2

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

Fincham VJ, Unlu M, Brunton VG, Pitts JD, Wyke JA, Frame MC. Fincham VJ, et al. Among authors: brunton vg. J Cell Biol. 1996 Dec;135(6 Pt 1):1551-64. doi: 10.1083/jcb.135.6.1551. J Cell Biol. 1996. PMID: 8978822 Free PMC article.

3

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer.

Brunton VG, Ozanne BW, Paraskeva C, Frame MC. Brunton VG, et al. Oncogene. 1997 Jan 23;14(3):283-93. doi: 10.1038/sj.onc.1200827. Oncogene. 1997. PMID: 9018114

4

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Agochiya M, Brunton VG, Owens DW, Parkinson EK, Paraskeva C, Keith WN, Frame MC. Agochiya M, et al. Among authors: brunton vg. Oncogene. 1999 Oct 7;18(41):5646-53. doi: 10.1038/sj.onc.1202957. Oncogene. 1999. PMID: 10523844

5

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts.

Owens DW, McLean GW, Wyke AW, Paraskeva C, Parkinson EK, Frame MC, Brunton VG. Owens DW, et al. Among authors: brunton vg. Mol Biol Cell. 2000 Jan;11(1):51-64. doi: 10.1091/mbc.11.1.51. Mol Biol Cell. 2000. PMID: 10637290 Free PMC article.

6

E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.

Owens DW, Brunton VG, Parkinson EK, Frame MC. Owens DW, et al. Among authors: brunton vg. Biochem Biophys Res Commun. 2000 Mar 16;269(2):369-76. doi: 10.1006/bbrc.2000.2292. Biochem Biophys Res Commun. 2000. PMID: 10708559

7

The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.

Fincham VJ, Brunton VG, Frame MC. Fincham VJ, et al. Among authors: brunton vg. Mol Cell Biol. 2000 Sep;20(17):6518-36. doi: 10.1128/MCB.20.17.6518-6536.2000. Mol Cell Biol. 2000. PMID: 10938128 Free PMC article.

8

Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase.

Jones RJ, Brunton VG, Frame MC. Jones RJ, et al. Among authors: brunton vg. Eur J Cancer. 2000 Aug;36(13 Spec No):1595-606. doi: 10.1016/s0959-8049(00)00153-2. Eur J Cancer. 2000. PMID: 10959046 Review.

9

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity.

Timpson P, Jones GE, Frame MC, Brunton VG. Timpson P, et al. Among authors: brunton vg. Curr Biol. 2001 Nov 27;11(23):1836-46. doi: 10.1016/s0960-9822(01)00583-8. Curr Biol. 2001. PMID: 11728306 Free article.

10

Advances in Rho-dependent actin regulation and oncogenic transformation.

Frame MC, Brunton VG. Frame MC, et al. Among authors: brunton vg. Curr Opin Genet Dev. 2002 Feb;12(1):36-43. doi: 10.1016/s0959-437x(01)00261-1. Curr Opin Genet Dev. 2002. PMID: 11790552 Review.

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