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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1993 1
1994 1
1996 1
1998 3
1999 16
2000 10
2001 6
2002 11
2003 10
2004 5
2005 7
2006 8
2007 7
2008 10
2009 9
2010 10
2011 11
2012 7
2013 15
2014 13
2015 17
2016 14
2017 13
2018 21
2019 11
2020 18
2021 26
2022 19
2023 14
2024 13

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297 results

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Page 1
Microduplication of BTRC detected in a Chinese family with split hand/foot malformation type 3.
Qiu L, Li C, Zheng G, Yang T, Yang F. Qiu L, et al. Clin Genet. 2022 Nov;102(5):451-456. doi: 10.1111/cge.14204. Epub 2022 Aug 8. Clin Genet. 2022. PMID: 35908152
SHFM3 is an autosomal dominant disease, which has been identified to associate with a 500 kb microduplication at 10q24. The duplication involved several genes, including LBX1, BTRC, POLL, FBXW4, and so forth. In the study, using trio clinical exome sequencing, a 120 kb mic …
SHFM3 is an autosomal dominant disease, which has been identified to associate with a 500 kb microduplication at 10q24. The duplication invo …
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-kappaB activation.
Lim YX, Lin H, Chu T, Lim YP. Lim YX, et al. Mol Oncol. 2022 Jan;16(2):422-446. doi: 10.1002/1878-0261.13048. Epub 2021 Aug 12. Mol Oncol. 2022. PMID: 34197030 Free PMC article.
Disruption of IkappaBalpha rescued the impaired migratory and invasive phenotypes in WBP2-silenced cells, while loss of BTRC ameliorated WBP2-driven migration and invasion. Clinically, the WBP2-BTRC-IkappaBalpha signaling axis correlates with poorer prognosis in bre …
Disruption of IkappaBalpha rescued the impaired migratory and invasive phenotypes in WBP2-silenced cells, while loss of BTRC ameliora …
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis.
Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, Huang Y, Li X, Peng XD, Feng GK, Li JD, Tang J, Zhu XF. Deng R, et al. Autophagy. 2021 Oct;17(10):3011-3029. doi: 10.1080/15548627.2020.1850609. Epub 2020 Dec 7. Autophagy. 2021. PMID: 33213267 Free PMC article.
Notably, phosphorylation of ULK1 by MAPK1/ERK2-MAPK3/ERK1 kinase triggers its interaction with BTRC and subsequent K48-linked ubiquitination and proteasome degradation. ...These results indicate that ULK1 knockout-mediated mitophagy defect promotes breast cancer bone metas …
Notably, phosphorylation of ULK1 by MAPK1/ERK2-MAPK3/ERK1 kinase triggers its interaction with BTRC and subsequent K48-linked ubiquit …
Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade.
Li S, Zeng M, Yang L, Tan J, Yang J, Guan H, Kuang M, Li J. Li S, et al. BMC Cancer. 2022 Oct 5;22(1):1044. doi: 10.1186/s12885-022-10040-5. BMC Cancer. 2022. PMID: 36199080 Free PMC article.
The prediction, dual luciferase assay, and response test results indicated that hsa-miR-10-5p and BTRC were involved in the lnc-SELPLG-2:1 cascade. Unlike lnc-SELPLG-2:1, hsa-hsa-miR-10a-5p had opposite expression and function. ...CONCLUSION: Lnc-SELPLG-2:1 is an oncogenes …
The prediction, dual luciferase assay, and response test results indicated that hsa-miR-10-5p and BTRC were involved in the lnc-SELPL …
miR-224 targets BTRC and promotes cell migration and invasion in colorectal cancer.
Zheng Q, Yu JJ, Li C, Li J, Wang J, Wang S. Zheng Q, et al. 3 Biotech. 2020 Nov;10(11):485. doi: 10.1007/s13205-020-02477-x. Epub 2020 Oct 24. 3 Biotech. 2020. PMID: 33117626 Free PMC article.
In reference to the Human Protein Atlas, BTRC protein expression was higher in normal tissues than in CRC tissues. In conclusion, miR-224 regulates its target BTRC protein expression and its related Wnt/beta-catenin pathway. ...
In reference to the Human Protein Atlas, BTRC protein expression was higher in normal tissues than in CRC tissues. In conclusion, miR …
The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase.
Qi W, Fang Z, Luo C, Hong H, Long Y, Dai Z, Liu J, Zeng Y, Zhou T, Xia Y, Yang X, Gao G. Qi W, et al. J Mol Cell Biol. 2024 Apr 4;15(10):mjad064. doi: 10.1093/jmcb/mjad064. J Mol Cell Biol. 2024. PMID: 37873692 Free PMC article.
Consequently, BTRC was identified as the E3 ligase for ATGL through predominant ubiquitination at the lysine 135 residue. ...Taken together, BTRC plays a crucial role in hepatic steatosis as a new ATGL E3 ligase and may serve as a potential therapeutic target for tr …
Consequently, BTRC was identified as the E3 ligase for ATGL through predominant ubiquitination at the lysine 135 residue. ...Taken to …
Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.
Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T. Ishimoto K, et al. Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5. Biochem Biophys Res Commun. 2017. PMID: 28483528
We show that Lipin-1 interacts with either of two E3 ubiquitin ligases, BTRC or FBXW11, and that this interaction is DSGXXS-dependent and mediates the attachment of polyubiquitin chains. Further, we demonstrate that degradation of Lipin-1 is regulated by BTRC in the …
We show that Lipin-1 interacts with either of two E3 ubiquitin ligases, BTRC or FBXW11, and that this interaction is DSGXXS-dependent …
Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.
Cui M, Peng J, Zhou Y, Wang X, Cui D. Cui M, et al. Thorac Cancer. 2023 Jul;14(21):2018-2025. doi: 10.1111/1759-7714.14984. Epub 2023 Jun 7. Thorac Cancer. 2023. PMID: 37287397 Free PMC article.
Immunohistochemistry was used to detect the protein expression of GPT2 and BTRC in cancer cells, animal models loaded with metastasis breast cancer cells were established via tail vein injections. Interaction between GPT2 and BTRC in breast cancer cells was investig …
Immunohistochemistry was used to detect the protein expression of GPT2 and BTRC in cancer cells, animal models loaded with metastasis …
297 results