Structures of complexes formed by HIV-1 reverse transcriptase at a termination site of DNA synthesis.
Lavigne M, Polomack L, Buc H.
Lavigne M, et al. Among authors: buc h.
J Biol Chem. 2001 Aug 17;276(33):31439-48. doi: 10.1074/jbc.M102976200. Epub 2001 Jun 11.
J Biol Chem. 2001.
PMID: 11402037
Free article.
First, the interactions between RT and the DNA duplex are less extended, although the global affinity of the enzyme for this duplex is only decreased by 2-fold. Second, there is an atypical positioning of the RT RNase H domain on the DNA duplex. We interpret our data as in …
First, the interactions between RT and the DNA duplex are less extended, although the global affinity of the enzyme for this duplex is only …