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Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques.
Igarashi T, Donau OK, Imamichi H, Nishimura Y, Theodore TS, Iyengar R, Erb C, Buckler-White A, Buckler CE, Martin MA. Igarashi T, et al. Among authors: buckler ce. J Virol. 2007 Oct;81(19):10669-79. doi: 10.1128/JVI.00517-07. Epub 2007 Jul 11. J Virol. 2007. PMID: 17626082 Free PMC article.
Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinical outcomes.
Igarashi T, Endo Y, Nishimura Y, Buckler C, Sadjadpour R, Donau OK, Dumaurier MJ, Plishka RJ, Buckler-White A, Martin MA. Igarashi T, et al. J Virol. 2003 Oct;77(20):10829-40. doi: 10.1128/jvi.77.20.10829-10840.2003. J Virol. 2003. PMID: 14512533 Free PMC article.
Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages.
Igarashi T, Donau OK, Imamichi H, Dumaurier MJ, Sadjadpour R, Plishka RJ, Buckler-White A, Buckler C, Suffredini AF, Lane HC, Moore JP, Martin MA. Igarashi T, et al. J Virol. 2003 Dec;77(24):13042-52. doi: 10.1128/jvi.77.24.13042-13052.2003. J Virol. 2003. PMID: 14645561 Free PMC article.
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