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The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.
Fiorcari S, Brown WS, McIntyre BW, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda WG, Keating MJ, Ding W, Kay NE, Lannutti BJ, Marasca R, Burger JA. Fiorcari S, et al. Among authors: burger ja. PLoS One. 2013 Dec 23;8(12):e83830. doi: 10.1371/journal.pone.0083830. eCollection 2013. PLoS One. 2013. PMID: 24376763 Free PMC article.
CXCR4 is a prognostic marker in acute myelogenous leukemia.
Spoo AC, Lübbert M, Wierda WG, Burger JA. Spoo AC, et al. Among authors: burger ja. Blood. 2007 Jan 15;109(2):786-91. doi: 10.1182/blood-2006-05-024844. Epub 2006 Aug 3. Blood. 2007. PMID: 16888090 Free article.
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.
Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. Niedermeier M, et al. Among authors: burger ja. Blood. 2009 May 28;113(22):5549-57. doi: 10.1182/blood-2008-06-165068. Epub 2009 Mar 24. Blood. 2009. PMID: 19318683 Free PMC article.
377 results