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The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R. Buschauer R, et al. Science. 2020 Apr 17;368(6488):eaay6912. doi: 10.1126/science.aay6912. Science. 2020. PMID: 32299921 Free PMC article.
Structure of the 80S ribosome-Xrn1 nuclease complex.
Tesina P, Heckel E, Cheng J, Fromont-Racine M, Buschauer R, Kater L, Beatrix B, Berninghausen O, Jacquier A, Becker T, Beckmann R. Tesina P, et al. Among authors: buschauer r. Nat Struct Mol Biol. 2019 Apr;26(4):275-280. doi: 10.1038/s41594-019-0202-5. Epub 2019 Mar 25. Nat Struct Mol Biol. 2019. PMID: 30911188
RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Matsuo Y, Tesina P, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Saeki Y, Becker T, Beckmann R, Inada T. Matsuo Y, et al. Among authors: buschauer r. Nat Struct Mol Biol. 2020 Apr;27(4):323-332. doi: 10.1038/s41594-020-0393-9. Epub 2020 Mar 23. Nat Struct Mol Biol. 2020. PMID: 32203490
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV. Osterman IA, et al. Among authors: buschauer r. Nat Chem Biol. 2020 Oct;16(10):1071-1077. doi: 10.1038/s41589-020-0578-x. Epub 2020 Jun 29. Nat Chem Biol. 2020. PMID: 32601485
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R. Thoms M, et al. Among authors: buschauer r. Science. 2020 Sep 4;369(6508):1249-1255. doi: 10.1126/science.abc8665. Epub 2020 Jul 17. Science. 2020. PMID: 32680882 Free PMC article.
Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria.
Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR. Saito K, et al. Among authors: buschauer r. Nature. 2022 Mar;603(7901):503-508. doi: 10.1038/s41586-022-04416-7. Epub 2022 Mar 9. Nature. 2022. PMID: 35264790 Free PMC article.
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