Search Page

1

Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA.

Bushweller JH. Bushweller JH. J Mol Biol. 2020 Apr 16:S0022-2836(20)30286-2. doi: 10.1016/j.jmb.2020.04.008. Online ahead of print. J Mol Biol. 2020. PMID: 32305461 Review.

Cite

Share

2

RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.

Fritz AJ, Hong D, Boyd J, Kost J, Finstaad KH, Fitzgerald MP, Hanna S, Abuarqoub AH, Malik M, Bushweller J, Tye C, Ghule P, Gordon J, Frietze S, Zaidi SK, Lian JB, Stein JL, Stein GS. Fritz AJ, et al. Among authors: Bushweller J. J Cell Physiol. 2020 Mar 17. doi: 10.1002/jcp.29625. Online ahead of print. J Cell Physiol. 2020. PMID: 32180230

Cite

Share

3

Targeting transcription factors in cancer - from undruggable to reality.

Bushweller JH. Bushweller JH. Nat Rev Cancer. 2019 Nov;19(11):611-624. doi: 10.1038/s41568-019-0196-7. Epub 2019 Sep 11. Nat Rev Cancer. 2019. PMID: 31511663 Review.

Cite

Share

4

The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma.

Alegre F, Ormonde AR, Godinez DR, Illendula A, Bushweller JH, Wittenburg LA. Alegre F, et al. Among authors: Bushweller JH. Vet Comp Oncol. 2020 Mar;18(1):52-63. doi: 10.1111/vco.12526. Epub 2019 Aug 22. Vet Comp Oncol. 2020. PMID: 31381810 Free PMC article.

Cite

Share

5

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.

Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KN. Mill CP, et al. Among authors: Bushweller JH. Blood. 2019 Jul 4;134(1):59-73. doi: 10.1182/blood.2018893982. Epub 2019 Apr 25. Blood. 2019. PMID: 31023702

Cite

Share

6

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

Zhou N, Gutierrez-Uzquiza A, Zheng XY, Chang R, Vogl DT, Garfall AL, Bernabei L, Saraf A, Florens L, Washburn MP, Illendula A, Bushweller JH, Busino L. Zhou N, et al. Among authors: Bushweller JH. Version 2. Leukemia. 2019 Aug;33(8):2006-2021. doi: 10.1038/s41375-019-0403-2. Epub 2019 Feb 13. Leukemia. 2019. PMID: 30760870 Free PMC article.

Cite

Share

7

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Pulikkan JA, et al. Among authors: Bushweller JH. Cell. 2018 Aug 23;174(5):1325. doi: 10.1016/j.cell.2018.08.014. Cell. 2018. PMID: 30142347 Free article. No abstract available.

Cite

Share

8

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Pulikkan JA, et al. Among authors: Bushweller JH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. Cell. 2018. PMID: 29958106 Free PMC article.

Cite

Share

9

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition.

Carlton AL, Illendula A, Gao Y, Llaneza DC, Boulton A, Shah A, Rajewski RA, Landen CN, Wotton D, Bushweller JH. Carlton AL, et al. Among authors: Bushweller JH. Gynecol Oncol. 2018 May;149(2):350-360. doi: 10.1016/j.ygyno.2018.03.005. Epub 2018 Mar 16. Gynecol Oncol. 2018. PMID: 29551565 Free PMC article.

Cite

Share

10

Solution structure and elevator mechanism of the membrane electron transporter CcdA.

Zhou Y, Bushweller JH. Zhou Y, et al. Among authors: Bushweller JH. Nat Struct Mol Biol. 2018 Feb;25(2):163-169. doi: 10.1038/s41594-018-0022-z. Epub 2018 Jan 29. Nat Struct Mol Biol. 2018. PMID: 29379172 Free PMC article.

Cite

Share