Bushweller JH - Search Results

1

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.

O'Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, Delgado-Tirado S, Hu X, Chmielewska N, Chandrahas A, Fitzek A, Heinrich F, Steurer S, Ondruschka B, Glatzel M, Krasemann S, Sepulveda-Falla D, Lagares D, Pedron J, Bushweller JH, Liu P, Arboleda-Velasquez JF, Kim LA. O'Hare M, et al. Among authors: bushweller jh. Am J Pathol. 2021 Jul;191(7):1193-1208. doi: 10.1016/j.ajpath.2021.04.006. Epub 2021 Apr 21. Am J Pathol. 2021. PMID: 33894177 Free PMC article.

2

Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.

Lukasik SM, Zhang L, Corpora T, Tomanicek S, Li Y, Kundu M, Hartman K, Liu PP, Laue TM, Biltonen RL, Speck NA, Bushweller JH. Lukasik SM, et al. Among authors: bushweller jh. Nat Struct Biol. 2002 Sep;9(9):674-9. doi: 10.1038/nsb831. Nat Struct Biol. 2002. PMID: 12172539

3

Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1.

Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP. Kamikubo Y, et al. Cancer Cell. 2010 May 18;17(5):455-68. doi: 10.1016/j.ccr.2010.03.022. Cancer Cell. 2010. PMID: 20478528 Free PMC article.

4

TNF-α signaling regulates RUNX1 function in endothelial cells.

Whitmore HAB, Amarnani D, O'Hare M, Delgado-Tirado S, Gonzalez-Buendia L, An M, Pedron J, Bushweller JH, Arboleda-Velasquez JF, Kim LA. Whitmore HAB, et al. Among authors: bushweller jh. FASEB J. 2021 Feb;35(2):e21155. doi: 10.1096/fj.202001668R. Epub 2020 Nov 2. FASEB J. 2021. PMID: 33135824 Free PMC article.

5

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation.

Yu L, Myers G, Ku CJ, Schneider E, Wang Y, Singh SA, Jearawiriyapaisarn N, White A, Moriguchi T, Khoriaty R, Yamamoto M, Rosenfeld MG, Pedron J, Bushweller JH, Lim KC, Engel JD. Yu L, et al. Among authors: bushweller jh. Blood. 2021 Nov 4;138(18):1691-1704. doi: 10.1182/blood.2021011682. Blood. 2021. PMID: 34324630 Free PMC article.

6

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH. Berardi MJ, et al. Among authors: bushweller jh. Structure. 1999 Oct 15;7(10):1247-56. doi: 10.1016/s0969-2126(00)80058-1. Structure. 1999. PMID: 10545320 Free article.

7

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.

Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. Illendula A, et al. Among authors: bushweller jh. Science. 2015 Feb 13;347(6223):779-84. doi: 10.1126/science.aaa0314. Science. 2015. PMID: 25678665 Free PMC article.

8

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.

Choi A, Illendula A, Pulikkan JA, Roderick JE, Tesell J, Yu J, Hermance N, Zhu LJ, Castilla LH, Bushweller JH, Kelliher MA. Choi A, et al. Among authors: bushweller jh. Blood. 2017 Oct 12;130(15):1722-1733. doi: 10.1182/blood-2017-03-775536. Epub 2017 Aug 8. Blood. 2017. PMID: 28790107 Free PMC article.

9

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.

Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH. Oo ZM, et al. Among authors: bushweller jh. Leuk Lymphoma. 2018 Sep;59(9):2188-2200. doi: 10.1080/10428194.2017.1410882. Epub 2017 Dec 18. Leuk Lymphoma. 2018. PMID: 29249175 Free PMC article.

10

The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma.

Alegre F, Ormonde AR, Godinez DR, Illendula A, Bushweller JH, Wittenburg LA. Alegre F, et al. Among authors: bushweller jh. Vet Comp Oncol. 2020 Mar;18(1):52-63. doi: 10.1111/vco.12526. Epub 2019 Aug 22. Vet Comp Oncol. 2020. PMID: 31381810 Free PMC article.

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