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Prognostic marker C3AR1 is associated with ovarian cancer cell proliferation and immunosuppression in the tumor microenvironment.
Huang J, Zhou L, Deng K. Huang J, et al. J Ovarian Res. 2023 Apr 1;16(1):64. doi: 10.1186/s13048-023-01140-2. J Ovarian Res. 2023. PMID: 37005667 Free PMC article.
BACKGROUND: C3AR1 was reported in driving tumor immunity in multiple cancers. However, its roles in ovarian cancer remain unclear. This study aims to determine role of C3AR1 in prognosis and regulating tumor infiltrating immune cells of ovarian canc …
BACKGROUND: C3AR1 was reported in driving tumor immunity in multiple cancers. However, its roles in ovarian cancer rema …
Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance.
Lawal B, Tseng SH, Olugbodi JO, Iamsaard S, Ilesanmi OB, Mahmoud MH, Ahmed SH, Batiha GE, Wu ATH. Lawal B, et al. Cancers (Basel). 2021 Aug 16;13(16):4124. doi: 10.3390/cancers13164124. Cancers (Basel). 2021. PMID: 34439277 Free PMC article.
We found that the complements C3, C5, C3AR1, and C5AR1 have deregulated expression in human malignancies and are associated with activation of immune-related oncogenic processes and poor prognosis of cancer patients. ...In conclusion, the complement components C3, C …
We found that the complements C3, C5, C3AR1, and C5AR1 have deregulated expression in human malignancies and are associated with acti …
Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats.
Xu J, Huang P, Bie B, Dai Y, Ben-Salem S, Borjini N, Zhang L, Chen J, Olman M, Cheng J, Lin F. Xu J, et al. J Immunol. 2023 Dec 1;211(11):1736-1746. doi: 10.4049/jimmunol.2300252. J Immunol. 2023. PMID: 37861348
Cancer chemotherapy-induced neuropathic pain is a devastating pain syndrome without effective therapies. ...Administration of C3aR1 antagonist to TRPV4 KO mice further protected them from PIMA. ...
Cancer chemotherapy-induced neuropathic pain is a devastating pain syndrome without effective therapies. ...Administration of C3aR …
Network pharmacology and experimental validation-based approach to understand the effect and mechanism of Taohong Siwu Decoction against ischemic stroke.
Pan L, Peng C, Wang L, Li L, Huang S, Fei C, Wang N, Chu F, Peng D, Duan X. Pan L, et al. J Ethnopharmacol. 2022 Aug 10;294:115339. doi: 10.1016/j.jep.2022.115339. Epub 2022 May 5. J Ethnopharmacol. 2022. PMID: 35525530
RESULTS: Established a component-target-pathway network, further transcriptomics analysis identified a total of 11 target genes (Plau, Fabp4, Mmp9, Mmp12, Cfd, Lcn2, Trem1, Lgals3, Hmox1, Selp and Slc6a4), a total of seven pathways (focal adhesion, complement and coagulation casc …
RESULTS: Established a component-target-pathway network, further transcriptomics analysis identified a total of 11 target genes (Plau, Fabp4 …
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, Atkinson C, Tomlinson S, Mehrotra S, Ogretmen B. Janneh AH, et al. Cell Rep. 2022 Dec 6;41(10):111742. doi: 10.1016/j.celrep.2022.111742. Cell Rep. 2022. PMID: 36476873 Free PMC article.
Moreover, targeting S1PR1/C3/PPIL1/NLRP3 signaling using molecular, genetic, and pharmacologic tools prevents lung colonization/metastasis of various murine cancer cell lines using WT and C3a-receptor1 knockout (C3aR1(-/-)) mice. ...
Moreover, targeting S1PR1/C3/PPIL1/NLRP3 signaling using molecular, genetic, and pharmacologic tools prevents lung colonization/metastasis o …
Integrative network-based analysis on multiple Gene Expression Omnibus datasets identifies novel immune molecular markers implicated in non-alcoholic steatohepatitis.
Zhang JJ, Shen Y, Chen XY, Jiang ML, Yuan FH, Xie SL, Zhang J, Xu F. Zhang JJ, et al. Front Endocrinol (Lausanne). 2023 Mar 16;14:1115890. doi: 10.3389/fendo.2023.1115890. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37008925 Free PMC article.
Hub genes with high degree of connectivity in the module, including CD53, LCP1, LAPTM5, NCKAP1L, C3AR1, PLEK, FCER1G, HLA-DRA and SRGN were further verified in clinical samples and mouse model of NASH. ...
Hub genes with high degree of connectivity in the module, including CD53, LCP1, LAPTM5, NCKAP1L, C3AR1, PLEK, FCER1G, HLA-DRA and SRG …
C3AR1 mRNA as a Potential Therapeutic Target Associates With Clinical Outcomes and Tumor Microenvironment in Osteosarcoma.
Zou T, Liu W, Wang Z, Chen J, Lu S, Huang K, Li W. Zou T, et al. Front Med (Lausanne). 2021 Mar 5;8:642615. doi: 10.3389/fmed.2021.642615. eCollection 2021. Front Med (Lausanne). 2021. PMID: 33748161 Free PMC article.
C3AR1 mRNA was closely correlated to various immune cells such as macrophages. C3AR1 was verified to be down-regulated in osteosarcoma tissues and cells. ...
C3AR1 mRNA was closely correlated to various immune cells such as macrophages. C3AR1 was verified to be down-regulated in oste …
Identification and Validation of CYBB, CD86, and C3AR1 as the Key Genes Related to Macrophage Infiltration of Gastric Cancer.
Chen H, Sun Q, Zhang C, She J, Cao S, Cao M, Zhang N, Adiila AV, Zhong J, Yao C, Wang Y, Xia H, Lan L. Chen H, et al. Front Mol Biosci. 2021 Dec 7;8:756085. doi: 10.3389/fmolb.2021.756085. eCollection 2021. Front Mol Biosci. 2021. PMID: 34950700 Free PMC article.
Gastric cancer (GC) is rampant around the world. Most of the GC cases are detected in advanced stages with poor prognosis. ...On the TIMER and THPA websites, it is verified that the expression levels of CYBB, CD86, and C3AR1 genes in tumor tissues were higher than t …
Gastric cancer (GC) is rampant around the world. Most of the GC cases are detected in advanced stages with poor prognosis. ...On the …
Stem cell-derived paracrine factors by modulated reactive oxygen species to enhance cancer immunotherapy.
Park N, Kim KS, Na K. Park N, et al. J Control Release. 2023 Nov;363:670-681. doi: 10.1016/j.jconrel.2023.10.011. Epub 2023 Oct 16. J Control Release. 2023. PMID: 37838223
By regulating the irradiated laser power, ACPFC promotes signaling pathways such as cascade-3, VEGFR2, alpha2beta1, C3AR1, CR1-4, and C5AR1, leading to the secretion of various inflammatory cytokines such as IFN-gamma, TGF-beta, and IL-6, while inhibiting AKT, ERK, NFkB, P …
By regulating the irradiated laser power, ACPFC promotes signaling pathways such as cascade-3, VEGFR2, alpha2beta1, C3AR1, CR1-4, and …
Endometriosis: A Malignant Fingerprint.
DeAngelo C, Tarasiewicz MB, Strother A, Taggart H, Gray C, Shanahan M, Glowacki C, Khandalavala J, Talaska E, Kinnan A, Coté JJ, Edwards AP, Harper-Harrison G, Casey MJ, Hirai TL, Schultz S, Stines L, Vora R, Boudreau D, Burgart J, Shama M, Watson T, Strasheim L, Thompson R, Lawlor R, Joyce K, Magnuson CM, Driano J, Elger B, Lentino A, Driscoll M, Tidwell E, Sharma A, Walker SR, Jones G, Sharma P, Stessman H, Wu Y, Vadgama J, Chase D, Conrad L, Reddy ST, Farias-Eisner R. DeAngelo C, et al. J Cancer Res Ther Oncol. 2020 Apr;8(2):206. doi: 10.17303/jcrto.2020.8.206. Epub 2020 Dec 29. J Cancer Res Ther Oncol. 2020. PMID: 33644256 Free PMC article.
These data were reviewed to identify key and relevant articles to create a comprehensive review article to explore the molecular fingerprint associated with in endometriosis-driven tumorigenesis. RESULTS: An important focus is the link between C3aR1, PGR, ER1, SOX-17 and o …
These data were reviewed to identify key and relevant articles to create a comprehensive review article to explore the molecular fingerprint …
53 results