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Identification and functional characterization of transcriptional activators in human cells.
Alerasool N, Leng H, Lin ZY, Gingras AC, Taipale M. Alerasool N, et al. Mol Cell. 2022 Feb 3;82(3):677-695.e7. doi: 10.1016/j.molcel.2021.12.008. Epub 2022 Jan 10. Mol Cell. 2022. PMID: 35016035 Free article.
Finally, we show that many novel activators are partners in fusion events in tumors and functionally characterize a myofibroma-associated fusion between SRF and C3orf62, a potent p300-dependent activator. Our work provides a functional catalog of potent transactivators in …
Finally, we show that many novel activators are partners in fusion events in tumors and functionally characterize a myofibroma-associated fu …
Identification and validation of a dysregulated TME-related gene signature for predicting prognosis, and immunological properties in bladder cancer.
Shen C, Chai W, Han J, Zhang Z, Liu X, Yang S, Wang Y, Wang D, Wan F, Fan Z, Hu H. Shen C, et al. Front Immunol. 2023 Oct 27;14:1213947. doi: 10.3389/fimmu.2023.1213947. eCollection 2023. Front Immunol. 2023. PMID: 37965307 Free PMC article.
Recently, there has been extensive attention on TME as a possible therapeutic target for cancers. However, an accurate TME-related prediction model is urgently needed to aid in the assessment of patients' prognoses and therapeutic value, and to assist in clinical decision- …
Recently, there has been extensive attention on TME as a possible therapeutic target for cancers. However, an accurate TME-related pr …
The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo.
Lin Z, Li D, Zheng J, Yao C, Liu D, Zhang H, Feng H, Chen C, Li P, Zhang Y, Jiang B, Hu Z, Zhao Y, Shi F, Cao D, Rodriguez-Wallberg KA, Li Z, Yeung WSB, Chow LT, Wang H, Liu K. Lin Z, et al. Cell Rep. 2024 Jan 23;43(1):113651. doi: 10.1016/j.celrep.2023.113651. Epub 2024 Jan 3. Cell Rep. 2024. PMID: 38175751 Free article.
Maps(delta2-9/delta2-9) male mice expressing MAPS protein lacking aa 2-9 phenocopy Maps(-/-) mice. Moreover, a frameshift mutation in C3orf62, the human counterpart of Maps, is correlated with nonobstructive azoospermia in a patient exhibiting pachynema arrest in spermatoc …
Maps(delta2-9/delta2-9) male mice expressing MAPS protein lacking aa 2-9 phenocopy Maps(-/-) mice. Moreover, a frameshift mutation in C3o …
The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology.
Vandenbrouck Y, Pineau C, Lane L. Vandenbrouck Y, et al. J Proteome Res. 2020 Dec 4;19(12):4782-4794. doi: 10.1021/acs.jproteome.0c00516. Epub 2020 Oct 16. J Proteome Res. 2020. PMID: 33064489 Free article.
Furthermore, this bioinformatics strategy allowed to build new functional hypotheses for five other uPE1s in link with phenotypic traits that are specific to male reproductive function such as ciliogenesis/flagellum formation in germ cells (CCDC112 and TEX9), chromatin remodeling …
Furthermore, this bioinformatics strategy allowed to build new functional hypotheses for five other uPE1s in link with phenotypic traits tha …
Recurrent SRF-RELA Fusions Define a Novel Subset of Cellular Myofibroma/Myopericytoma: A Potential Diagnostic Pitfall With Sarcomas With Myogenic Differentiation.
Antonescu CR, Sung YS, Zhang L, Agaram NP, Fletcher CD. Antonescu CR, et al. Am J Surg Pathol. 2017 May;41(5):677-684. doi: 10.1097/PAS.0000000000000811. Am J Surg Pathol. 2017. PMID: 28248815 Free PMC article.
One chest wall soft tissue tumor in a 3-month-old girl case showed a SRF-C3orf62 fusion, while the other, a forearm lesion in an 8-year-old girl, showed a SRF-RELA fusion. ...
One chest wall soft tissue tumor in a 3-month-old girl case showed a SRF-C3orf62 fusion, while the other, a forearm lesion in an 8-ye …