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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
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2006 1
2008 2
2009 2
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2012 3
2013 4
2014 10
2015 20
2016 21
2017 13
2018 7
2019 9
2020 9
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2022 14
2023 5
2024 4

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125 results

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Page 1
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Devis-Jauregui L, et al. Autophagy. 2021 May;17(5):1077-1095. doi: 10.1080/15548627.2020.1752548. Epub 2020 May 13. Autophagy. 2021. PMID: 32401642 Free PMC article. Review.
The current review highlights the most recent findings regarding the process of autophagy in the normal and cancerous endometrial tissue. Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.Abbreviations …
The current review highlights the most recent findings regarding the process of autophagy in the normal and cancerous endometrial tis …
CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation.
McKerr N, Mohd-Sarip A, Dorrian H, Breen C, A James J, McQuaid S, Mills IG, McCloskey KD. McKerr N, et al. Sci Rep. 2023 Mar 22;13(1):4683. doi: 10.1038/s41598-023-28693-y. Sci Rep. 2023. PMID: 36949059 Free PMC article.
CACNA1D, encoding Ca(V)1.3 ion channels is upregulated in prostate cancer. ...Nifedipine, Bay K 8644 (Ca(V)1.3 inhibitor, activator), mibefradil, Ni(2+) (Ca(V)3.2 inhibitors) and high K(+) depolarising solution were employed. CACNA1D and Ca(V)1.3 protein are …
CACNA1D, encoding Ca(V)1.3 ion channels is upregulated in prostate cancer. ...Nifedipine, Bay K 8644 (Ca(V)1.3 inhibitor, acti …
Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.
Liu ZX, Zhang XL, Zhao Q, Chen Y, Sheng H, He CY, Sun YT, Lai MY, Wu MQ, Zuo ZX, Wang W, Zhou ZW, Wang FH, Li YH, Xu RH, Qiu MZ. Liu ZX, et al. JAMA Netw Open. 2022 Dec 1;5(12):e2245836. doi: 10.1001/jamanetworkopen.2022.45836. JAMA Netw Open. 2022. PMID: 36484990 Free PMC article.
IMPORTANCE: The E-cadherin gene, CDH1, and the alpha-E-catenin gene, CTNNA1, were previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes, explaining 25% to 50% of HDGC cases. ...Furthermore, enrichment of the somatic variant signature of exp …
IMPORTANCE: The E-cadherin gene, CDH1, and the alpha-E-catenin gene, CTNNA1, were previously identified as hereditary diffuse gastric can …
Genetics of Primary Aldosteronism.
Scholl UI. Scholl UI. Hypertension. 2022 May;79(5):887-897. doi: 10.1161/HYPERTENSIONAHA.121.16498. Epub 2022 Feb 10. Hypertension. 2022. PMID: 35139664 Free PMC article. Review.
More than 90% of aldosterone-producing adenomas carry somatic mutations in K(+) channel Kir3.4 (KCNJ5), Ca(2+) channel Ca(V)1.3 (CACNA1D), alpha-1 subunit of the Na(+)/K(+) ATPase (ATP1A1), plasma membrane Ca(2+) transporting ATPase 3 (ATP2B3), Ca(2+) channel Ca(V)3.2 (CAC …
More than 90% of aldosterone-producing adenomas carry somatic mutations in K(+) channel Kir3.4 (KCNJ5), Ca(2+) channel Ca(V)1.3 (CACNA1D …
Primary Aldosteronism.
Funder JW. Funder JW. Hypertension. 2019 Sep;74(3):458-466. doi: 10.1161/HYPERTENSIONAHA.119.12935. Epub 2019 Jul 22. Hypertension. 2019. PMID: 31327272 Free article. Review. No abstract available.
Update on the Genetics of Primary Aldosteronism and Aldosterone-Producing Adenomas.
Pitsava G, Faucz FR, Stratakis CA, Hannah-Shmouni F. Pitsava G, et al. Curr Cardiol Rep. 2022 Sep;24(9):1189-1195. doi: 10.1007/s11886-022-01735-z. Epub 2022 Jul 16. Curr Cardiol Rep. 2022. PMID: 35841527 Free PMC article. Review.
We discuss recent discoveries in the genetics of PA. RECENT FINDINGS: Most APAs harbor variants in the KCNJ5, CACNA1D, ATP1A1, ATP2B3, and CTNNB1 genes. With the exception of beta-catenin (CTNNB1), all other causative genes encode ion channels; pathogenic variants found in …
We discuss recent discoveries in the genetics of PA. RECENT FINDINGS: Most APAs harbor variants in the KCNJ5, CACNA1D, ATP1A1, ATP2B3 …
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome.
Santana LS, Guimaraes AG, Almeida MQ. Santana LS, et al. Front Endocrinol (Lausanne). 2022 Jun 23;13:927669. doi: 10.3389/fendo.2022.927669. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35813615 Free PMC article. Review.
Primary aldosteronism (PA) is the most common form of secondary arterial hypertension, with a prevalence of approximately 20% in patients with resistant hypertension. In the last decade, somatic pathogenic variants in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 genes, which are invo …
Primary aldosteronism (PA) is the most common form of secondary arterial hypertension, with a prevalence of approximately 20% in patients wi …
Genetics of primary hyperaldosteronism.
Dutta RK, Söderkvist P, Gimm O. Dutta RK, et al. Endocr Relat Cancer. 2016 Oct;23(10):R437-54. doi: 10.1530/ERC-16-0055. Epub 2016 Aug 2. Endocr Relat Cancer. 2016. PMID: 27485459 Review.
Several novel susceptibility genes have been found to be mutated in aldosterone-producing adenomas: KCNJ5, ATP1A1, ATP2B3, CTNNB1, CACNA1D, CACNA1H and ARMC5 This review describes the genes currently known to be responsible for primary aldosteronism, discusses the origin o …
Several novel susceptibility genes have been found to be mutated in aldosterone-producing adenomas: KCNJ5, ATP1A1, ATP2B3, CTNNB1, CACNA1 …
CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer.
O'Reilly D, Downing T, Kouba S, Potier-Cartereau M, McKenna DJ, Vandier C, Buchanan PJ. O'Reilly D, et al. Cell Calcium. 2022 May;103:102554. doi: 10.1016/j.ceca.2022.102554. Epub 2022 Feb 12. Cell Calcium. 2022. PMID: 35193095 Free article.
There is growing evidence that voltage gated calcium channel (VGCC) expression is increased in cancer, particularly CACNA1D/CaV1.3 in CRPC. The aim of this study was to investigate if increased CaV1.3 drives resistance to ADT and determine its associated impact on C …
There is growing evidence that voltage gated calcium channel (VGCC) expression is increased in cancer, particularly CACNA1D/Ca …
Adrenocortical tumorigenesis: Lessons from genetics.
Kamilaris CDC, Hannah-Shmouni F, Stratakis CA. Kamilaris CDC, et al. Best Pract Res Clin Endocrinol Metab. 2020 May;34(3):101428. doi: 10.1016/j.beem.2020.101428. Epub 2020 May 23. Best Pract Res Clin Endocrinol Metab. 2020. PMID: 32507359 Free PMC article. Review.
Genetic alterations in GNAS, PRKAR1A, PRKACA, PRKACB, PDE11A, and PDE8B, that lead to aberrant cyclic adenosine monophosphate-protein (cAMP) kinase A signaling, were found to play a major role in the development of benign cortisol-producing adrenocortical tumors and/or hyperplasi …
Genetic alterations in GNAS, PRKAR1A, PRKACA, PRKACB, PDE11A, and PDE8B, that lead to aberrant cyclic adenosine monophosphate-protein (cAMP) …
125 results