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Year Number of Results
2001 1
2003 2
2004 1
2008 2
2013 1
2014 3
2015 4
2016 2
2018 9
2019 2
2020 3
2021 9
2022 9
2023 4
2024 4

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52 results

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Page 1
Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.
Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. Inoue H, et al. Ann Surg Oncol. 2022 Apr 20. doi: 10.1245/s10434-022-11752-5. Online ahead of print. Ann Surg Oncol. 2022. PMID: 35445337
The aim of our study was to investigate the role of CACNA2D1 and evaluate the efficacy of amlodipine, a blocker of CACNA2D1, in the treatment of gastric cancer (GC). ...RESULTS: Cell proliferation, migration, and invasion were suppressed in CACNA2D1-de …
The aim of our study was to investigate the role of CACNA2D1 and evaluate the efficacy of amlodipine, a blocker of CACNA2D1, i …
PRLR and CACNA2D1 Impact the Prognosis of Breast Cancer by Regulating Tumor Immunity.
Liang J, Deng Y, Zhang Y, Wu B, Zhou J. Liang J, et al. J Pers Med. 2022 Dec 19;12(12):2086. doi: 10.3390/jpm12122086. J Pers Med. 2022. PMID: 36556307 Free PMC article.
Our results showed that PRLR might be harmful to BC, while CACNA2D1 might be beneficial to BC. Furthermore, the abnormal expression of PRLR in BC might result from mutation and hypomethylation, while the aberrant expression of CACNA2D1 might be ascribed to methylati …
Our results showed that PRLR might be harmful to BC, while CACNA2D1 might be beneficial to BC. Furthermore, the abnormal expression o …
CACNA2D1 regulates the progression and influences the microenvironment of colon cancer.
Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E. Inoue H, et al. J Gastroenterol. 2024 Mar 27. doi: 10.1007/s00535-024-02095-x. Online ahead of print. J Gastroenterol. 2024. PMID: 38536483
The fibroblast cell line CCD-18Co was co-cultured with CC cell lines to determine the effect of CACNA2D1 on fibroblasts and the relationship between CACNA2D1 and the cancer microenvironment. ...CCD-18Co and HCT116 or RKO cell co-culture revealed that CACNA …
The fibroblast cell line CCD-18Co was co-cultured with CC cell lines to determine the effect of CACNA2D1 on fibroblasts and the relat …
Calcium channel alpha2delta1 subunit (CACNA2D1) enhances radioresistance in cancer stem-like cells in non-small cell lung cancer cell lines.
Sui X, Geng JH, Li YH, Zhu GY, Wang WH. Sui X, et al. Cancer Manag Res. 2018 Oct 26;10:5009-5018. doi: 10.2147/CMAR.S176084. eCollection 2018. Cancer Manag Res. 2018. PMID: 30464601 Free PMC article.
PURPOSE: Radiotherapy is a major treatment method for patients with non-small cell lung cancer (NSCLC). However, the presence of radioresistant cancer stem cells (CSCs) may be associated with disease relapse or a poor outcome after radiotherapy. ...MATERIALS AND MET …
PURPOSE: Radiotherapy is a major treatment method for patients with non-small cell lung cancer (NSCLC). However, the presence of radi …
Prognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective study.
Yu D, Holm R, Goscinski MA, Trope CG, Nesland JM, Suo Z. Yu D, et al. Am J Cancer Res. 2016 Sep 1;6(9):2088-2097. eCollection 2016. Am J Cancer Res. 2016. PMID: 27725913 Free PMC article.
Ovarian cancer is the most lethal gynecologic malignancy, in which cancer stem cells (CSC) have been reported to be the driving force of relapse and therapy-resistance. It is therefore important to explore CSC markers in ovarian cancer. This project aimed to …
Ovarian cancer is the most lethal gynecologic malignancy, in which cancer stem cells (CSC) have been reported to be the drivin …
[MicroRNA-107 inhibits the proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1].
Huang C, Wang Y, Huang S, Wang Z, Liu L. Huang C, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Oct;34(10):911-918. doi: 10.13201/j.issn.2096-7993.2020.10.011. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020. PMID: 33254297 Free PMC article. Chinese.
Objective:To detect the expression of microRNA-107 (miR-107) and the calcium channel protein gene CACNA2D1 in laryngeal cancer tissues, to investigate the targeting relationship between miR-107 and CACNA2D1, and to analyze the effects of miR-107 on the prolif …
Objective:To detect the expression of microRNA-107 (miR-107) and the calcium channel protein gene CACNA2D1 in laryngeal cancer …
The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.
Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. Chen J, et al. Cell Rep. 2018 Feb 27;22(9):2307-2321. doi: 10.1016/j.celrep.2018.02.021. Cell Rep. 2018. PMID: 29490268 Free PMC article.
However, it is unclear how alpha2delta-1 contributes to neuropathic pain and gabapentinoid actions. Here, we show that Cacna2d1 overexpression potentiates presynaptic and postsynaptic NMDAR activity of spinal dorsal horn neurons to cause pain hypersensitivity. Conversely, …
However, it is unclear how alpha2delta-1 contributes to neuropathic pain and gabapentinoid actions. Here, we show that Cacna2d1 overe …
MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.
Huang C, Wang Z, Zhang K, Dong Y, Zhang A, Lu C, Liu L. Huang C, et al. Anticancer Drugs. 2020 Mar;31(3):260-271. doi: 10.1097/CAD.0000000000000865. Anticancer Drugs. 2020. PMID: 31725046 Free PMC article.
Our previous studies have confirmed that alpha2delta1 has the potential to function as a cancer stem cell marker, and CACNA2D1 is the coding gene of alpha2delta1. But it is unclear how microRNAs regulate the expression of the CACNA2D1 gene in laryngeal can …
Our previous studies have confirmed that alpha2delta1 has the potential to function as a cancer stem cell marker, and CACNA2D1 …
52 results