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Did you mean care cancer (421,744 results)?
CARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway.
Dong W, Cao Z, Pang Y, Feng T, Tian H. Dong W, et al. Onco Targets Ther. 2019 Nov 1;12:9041-9051. doi: 10.2147/OTT.S225733. eCollection 2019. Onco Targets Ther. 2019. PMID: 31802911 Free PMC article.
Here, we report that CARF promotes colorectal cancer stemness through ERBB signaling pathway. ...CONCLUSION: CARF, as an oncogene, promotes colorectal cancer stemness by activating ERBB signaling pathway. ...
Here, we report that CARF promotes colorectal cancer stemness through ERBB signaling pathway. ...CONCLUSION: CARF, as a …
Molecular bridging of aging and cancer: A CARF link.
Cheung CT, Kaul SC, Wadhwa R. Cheung CT, et al. Ann N Y Acad Sci. 2010 Jun;1197:129-33. doi: 10.1111/j.1749-6632.2009.05392.x. Ann N Y Acad Sci. 2010. PMID: 20536841 Review.
Knockdown of CARF resulted in mitotic arrest leading to excessive chromosomal condensation, aneuploidy, and apoptosis, suggesting that CARF is essential for cell survival. Most recently, we have found that CARF causes bidirectional regulation of p53 and pRB p …
Knockdown of CARF resulted in mitotic arrest leading to excessive chromosomal condensation, aneuploidy, and apoptosis, suggesting tha …
CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.
Wadhwa R, Kalra RS, Kaul SC. Wadhwa R, et al. Mech Ageing Dev. 2017 Sep;166:64-68. doi: 10.1016/j.mad.2017.07.008. Epub 2017 Jul 25. Mech Ageing Dev. 2017. PMID: 28754531 Review.
Cells with CARF-overexpression (CARF-OE) and superexpression (CARF-SE) showed growth arrest and pro-proliferative phenotypes, respectively. ...We discuss how thresh-hold of CARF level determines fate of cells to senescence and malignant transformation. …
Cells with CARF-overexpression (CARF-OE) and superexpression (CARF-SE) showed growth arrest and pro-proliferative pheno …
Inhibition of MicroRNA-302c on Stemness of Colon Cancer Stem Cells via the CARF/Wnt/beta-Catenin Axis.
Zhang Y, Meng H, Guo K. Zhang Y, et al. Dig Dis Sci. 2021 Jun;66(6):1906-1915. doi: 10.1007/s10620-020-06435-8. Epub 2020 Jul 2. Dig Dis Sci. 2021. PMID: 32617772
BACKGROUND: Even though the relevance of microRNA (miR)-302c has been studied, little is known about its involvement in colon cancer (CC). AIMS: Our aim here was to investigate the role of miR-302c in the cancer stem cells (CSCs) of CC. ...Also, miR-302c reduced tum …
BACKGROUND: Even though the relevance of microRNA (miR)-302c has been studied, little is known about its involvement in colon cancer …
CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.
Cheung CT, Hasan MK, Widodo N, Kaul SC, Wadhwa R. Cheung CT, et al. Mech Ageing Dev. 2009 Jan-Feb;130(1-2):18-23. doi: 10.1016/j.mad.2008.05.002. Epub 2008 May 8. Mech Ageing Dev. 2009. PMID: 18555516 Review.
CARF directly binds to p53 and HDM2, and functions in a negative feedback pathway. Whereas CARF transcriptionally represses HDM2 to increase p53 activity, HDM2 in return degrades CARF. ...
CARF directly binds to p53 and HDM2, and functions in a negative feedback pathway. Whereas CARF transcriptionally represses HD …
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Cheung CT, Singh R, Yoon AR, Hasan MK, Yaguchi T, Kaul SC, Yun CO, Wadhwa R. Cheung CT, et al. Cell Death Differ. 2011 Apr;18(4):589-601. doi: 10.1038/cdd.2010.129. Epub 2010 Nov 5. Cell Death Differ. 2011. PMID: 21052095 Free PMC article.
We had previously reported that CARF inhibition in cancer cells led to polyploidy and caspase-dependent apoptosis, however, the mechanisms governing this phenomenon remained unknown. ...We demonstrate that CARF has a vital role in genome preservation and tumo …
We had previously reported that CARF inhibition in cancer cells led to polyploidy and caspase-dependent apoptosis, however, th …
CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma.
Fan X, Ma X, Cui L, Dang S, Qu J, Zhang J, Wang X, Mao Z. Fan X, et al. Oncotarget. 2016 Dec 6;7(49):80404-80414. doi: 10.18632/oncotarget.13138. Oncotarget. 2016. PMID: 27829235 Free PMC article.
Overexpression of CARF promoted the growth and migration of HCC cells, while knocking down the expression of CARF inhibited the growth and migration of HCC cells. ...Moreover, knocking down the expression of CARF inhibited the tumorigenesis in the HCC mouse m …
Overexpression of CARF promoted the growth and migration of HCC cells, while knocking down the expression of CARF inhibited th …
CARF enrichment promotes epithelial-mesenchymal transition via Wnt/beta-catenin signaling: its clinical relevance and potential as a therapeutic target.
Kalra RS, Chaudhary A, Yoon AR, Bhargava P, Omar A, Garg S, Yun CO, Kaul SC, Wadhwa R. Kalra RS, et al. Oncogenesis. 2018 May 11;7(5):39. doi: 10.1038/s41389-018-0048-4. Oncogenesis. 2018. PMID: 29748568 Free PMC article.
Consistent with the clinical readouts, enrichment of CARF in cancer cells promoted epithelial-mesenchymal transition (EMT). ...Taken together, we report clinical and therapeutic relevance of CARF in EMT and cancer invasiveness/metastasis, and propose i …
Consistent with the clinical readouts, enrichment of CARF in cancer cells promoted epithelial-mesenchymal transition (EMT). .. …
Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells.
Omar A, Kalra RS, Putri J, Elwakeel A, Kaul SC, Wadhwa R. Omar A, et al. Sci Rep. 2020 Apr 14;10(1):6323. doi: 10.1038/s41598-020-62953-5. Sci Rep. 2020. PMID: 32286347 Free PMC article.
We screened some phytochemicals for cytotoxic activity to human cancer cells and identified Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. ...Targeting of CARF by Snol-A also caused (i) downregulation of pATR-Chk1 signaling leading to ca …
We screened some phytochemicals for cytotoxic activity to human cancer cells and identified Soyasapogenol-A (Snol-A) as a potent cand …
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Cheung CT, Singh R, Kalra RS, Kaul SC, Wadhwa R. Cheung CT, et al. J Biol Chem. 2014 Jun 27;289(26):18258-69. doi: 10.1074/jbc.M114.547208. Epub 2014 May 13. J Biol Chem. 2014. PMID: 24825908 Free PMC article.
We found that the dosage of CARF is a critical factor in determining the proliferation potential of cancer cells. Most surprisingly, although a moderate level of CARF overexpression induced senescence, a very high level of CARF resulted in increased ce …
We found that the dosage of CARF is a critical factor in determining the proliferation potential of cancer cells. Most surpris …
52 results