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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 2
1996 19
1997 66
1998 157
1999 234
2000 367
2001 469
2002 554
2003 723
2004 789
2005 943
2006 1001
2007 1102
2008 1183
2009 1272
2010 1383
2011 1631
2012 1827
2013 1936
2014 2091
2015 2242
2016 2151
2017 2304
2018 2500
2019 2341
2020 2389
2021 2244
2022 2032
2023 1804
2024 805

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34,121 results

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Page 1
The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review.
Bhat AA, Thapa R, Afzal O, Agrawal N, Almalki WH, Kazmi I, Alzarea SI, Altamimi ASA, Prasher P, Singh SK, Dua K, Gupta G. Bhat AA, et al. Int J Biol Macromol. 2023 Jul 1;242(Pt 2):124832. doi: 10.1016/j.ijbiomac.2023.124832. Epub 2023 May 15. Int J Biol Macromol. 2023. PMID: 37196719 Review.
These proteins may serve as therapeutic biomarkers for cancer detection, and their antagonists may be a new target. Caspase-3, a crucial protein in both pyroptosis and apoptosis, governs tumour cytotoxicity when activated, and GSDME expression modulates this. …
These proteins may serve as therapeutic biomarkers for cancer detection, and their antagonists may be a new target. Caspase- …
Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.
Zhou M, Liu X, Li Z, Huang Q, Li F, Li CY. Zhou M, et al. Int J Cancer. 2018 Aug 15;143(4):921-930. doi: 10.1002/ijc.31374. Epub 2018 Mar 30. Int J Cancer. 2018. PMID: 29524226 Free PMC article.
Caspase-3 (CASP3) is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy or immunotherapy. ...Therefore, the roles of caspase-3 in tumor progression remain to be defined clearly. In our study, we est …
Caspase-3 (CASP3) is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy …
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'Sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, Thorburn A, Jimeno A, Raben D, Bedford JS, Li CY. Huang Q, et al. Nat Med. 2011 Jul 3;17(7):860-6. doi: 10.1038/nm.2385. Nat Med. 2011. PMID: 21725296 Free PMC article.
In human subjects with cancer, higher amounts of activated caspase 3 in tumor tissues are correlated with markedly increased rate of recurrence and death. We propose the existence of a cell death-induced tumor repopulation pathway in which caspase 3 …
In human subjects with cancer, higher amounts of activated caspase 3 in tumor tissues are correlated with markedly incr …
Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway.
Zhang Z, Zhang H, Li D, Zhou X, Qin Q, Zhang Q. Zhang Z, et al. J Cell Mol Med. 2021 Sep;25(17):8159-8168. doi: 10.1111/jcmm.16574. Epub 2021 Aug 8. J Cell Mol Med. 2021. PMID: 34369076 Free PMC article.
Also, protein expression analyses revealed GSDME as a key regulator in DOX-induced pyroptosis and highlighted the related role of Caspase-3 activation. Furthermore, DOX treatments induced intracellular accumulation of ROS, stimulated the phosphorylation of JNK, and …
Also, protein expression analyses revealed GSDME as a key regulator in DOX-induced pyroptosis and highlighted the related role of Caspase …
Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model.
Ke H, Wang X, Zhou Z, Ai W, Wu Z, Zhang Y. Ke H, et al. J Ethnopharmacol. 2021 Jan 10;264:113363. doi: 10.1016/j.jep.2020.113363. Epub 2020 Sep 9. J Ethnopharmacol. 2021. PMID: 32916234
AIM OF THE STUDY: To investigate the effect of WMN on the cellular activity and apoptosis of mouse breast cancer 4T1-luc2 cells, and caspase-3 and cleaved-caspase-3 expression. ...CONCLUSION: WMN can effectively suppress the growth of 4T1-luc2 b …
AIM OF THE STUDY: To investigate the effect of WMN on the cellular activity and apoptosis of mouse breast cancer 4T1-luc2 cells, and …
Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation.
Zhang CC, Li CG, Wang YF, Xu LH, He XH, Zeng QZ, Zeng CY, Mai FY, Hu B, Ouyang DY. Zhang CC, et al. Apoptosis. 2019 Apr;24(3-4):312-325. doi: 10.1007/s10495-019-01515-1. Apoptosis. 2019. PMID: 30710195
Consistent with this, cisplatin triggered much higher activation of caspase-3 and generation of GSDME-NT than paclitaxel, suggesting that the levels of secondary necrosis/pyroptosis correlated with the levels of active caspase-3 and GSDME-NT. Supportin …
Consistent with this, cisplatin triggered much higher activation of caspase-3 and generation of GSDME-NT than paclitaxel, sugg …
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases.
Raman V, Van Dessel N, Hall CL, Wetherby VE, Whitney SA, Kolewe EL, Bloom SMK, Sharma A, Hardy JA, Bollen M, Van Eynde A, Forbes NS. Raman V, et al. Nat Commun. 2021 Oct 21;12(1):6116. doi: 10.1038/s41467-021-26367-9. Nat Commun. 2021. PMID: 34675204 Free PMC article.
Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. ...The autonomous triggering of lysis after invasion makes the platform self-limiting and prevents drug release in healthy organs. Bacterial delivery of constitutively …
Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. ...The autonomous triggering …
Genetic Polymorphisms in the Apoptosis-Associated Gene CASP3 and the Risk of Lung Cancer in Chinese Population.
Lin J, Zhang Y, Wang H, Chang J, Wei L, Cao L, Zhang Z, Zhang X. Lin J, et al. PLoS One. 2016 Oct 10;11(10):e0164358. doi: 10.1371/journal.pone.0164358. eCollection 2016. PLoS One. 2016. PMID: 27723786 Free PMC article. Clinical Trial.
Caspase-3 (CASP3) plays a central role in executing cell apoptosis and thus in carcinogenesis. We previously investigated the relationship between functional polymorphisms in CAPS3 829 A>C and 20541 C>T and risk of esophageal squamous cell carcinoma. Ho …
Caspase-3 (CASP3) plays a central role in executing cell apoptosis and thus in carcinogenesis. We previously investigat …
The effect of CASP3 rs4647610 and rs4647602 polymorphisms on tumour size and cancer stage in papillary thyroid carcinoma.
Heidari Z, Eskandari M, Aryan A, Rostamzad F, Salimi S. Heidari Z, et al. Br J Biomed Sci. 2020 Jul;77(3):129-134. doi: 10.1080/09674845.2020.1741249. Epub 2020 May 13. Br J Biomed Sci. 2020. PMID: 32151194
Caspase-3 is an important apoptotic component and its abnormal function may play a key role in cancer pathogenesis. ...No association was observed between CASP3 polymorphisms and other PTC outcomes. CONCLUSION: Although CASP3 rs4647610 and rs464 …
Caspase-3 is an important apoptotic component and its abnormal function may play a key role in cancer pathogenesis. ... …
[Association of CASP3 polymorphisms and its haplotypes with susceptibility of breast cancer].
Ni Q, Liu B, Jin MJ, Ma XY, Yao KY, Li QL, Chen K. Ni Q, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 May;40(3):259-64. doi: 10.3785/j.issn.1008-9292.2011.03.005. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011. PMID: 21671484 Chinese.
OBJECTIVE: To investigate the association of Caspase3 (CASP3) polymorphisms with susceptibility of breast cancer in Chinese Han population. ...No significant differences were detected in the distribution of CASP3 genotype and haplotype frequencies between bre …
OBJECTIVE: To investigate the association of Caspase3 (CASP3) polymorphisms with susceptibility of breast cancer in Chinese Ha …
34,121 results
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