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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1978 2
1979 1
1980 2
1982 2
1983 1
1984 2
1985 2
1986 5
1987 3
1988 5
1989 7
1990 5
1991 6
1992 7
1993 5
1994 4
1995 12
1996 18
1997 36
1998 18
1999 29
2000 22
2001 29
2002 27
2003 32
2004 33
2005 21
2006 36
2007 47
2008 39
2009 50
2010 72
2011 74
2012 91
2013 87
2014 90
2015 88
2016 78
2017 70
2018 75
2019 69
2020 88
2021 91
2022 90
2023 74
2024 40

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1,534 results

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Page 1
Targeting Cbl-b in cancer immunotherapy.
Augustin RC, Bao R, Luke JJ. Augustin RC, et al. J Immunother Cancer. 2023 Feb;11(2):e006007. doi: 10.1136/jitc-2022-006007. J Immunother Cancer. 2023. PMID: 36750253 Free PMC article. Review.
Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of patients with various malignancies, yet a majority do not benefit or develop resistance. ...Overall, novel Cbl-b inhibitors provide antigen-specific immune stimulation and are a promis …
Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of patients with various malignancies, yet a majority …
Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function.
Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. Kumar J, et al. J Immunother Cancer. 2021 Jan;9(1):e001688. doi: 10.1136/jitc-2020-001688. J Immunother Cancer. 2021. PMID: 33462140 Free PMC article.
METHODS: Analysis of RNA-sequencing data from CD8(+) tumor-infiltrating lymphocytes (TILs) led to identification of Cbl-b as a potential target. The sequencing data were validated using a syngeneic MC38 colon cancer model. To analyze the in vivo role of Cbl-b …
METHODS: Analysis of RNA-sequencing data from CD8(+) tumor-infiltrating lymphocytes (TILs) led to identification of Cbl-b as a potent …
SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation.
Zhang S, Jia X, Dai H, Zhu X, Song W, Bian S, Wu H, Chen S, Tang Y, Chen J, Jin C, Zhou M, Xie H, Zheng S, Song P. Zhang S, et al. Cancer Commun (Lond). 2024 Mar;44(3):384-407. doi: 10.1002/cac2.12527. Epub 2024 Feb 26. Cancer Commun (Lond). 2024. PMID: 38407942 Free PMC article.
In this study, we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis. METHODS: The Cancer Genome Atlas database (TCGA), including DNA methylation and transcriptome sequencing data, was utilized to identify the crucial oncogene associ …
In this study, we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis. METHODS: The Cancer Gen …
Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.
Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Yang YM, Folts C, Stripay J, Chen HY, Stevens BM. Noble M, et al. Free Radic Biol Med. 2015 Feb;79:300-23. doi: 10.1016/j.freeradbiomed.2014.10.860. Epub 2014 Dec 4. Free Radic Biol Med. 2015. PMID: 25481740 Free PMC article. Review.
Inhibition of these proteins to restore normal c-Cbl function suppresses cancer cell division, increases sensitivity to chemotherapy, disrupts tumor-initiating cell (TIC) activity in GBMs and BLBCs, controls multiple critical TIC regulators, and also allows targetin …
Inhibition of these proteins to restore normal c-Cbl function suppresses cancer cell division, increases sensitivity to chemot …
Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.
Liyasova MS, Ma K, Lipkowitz S. Liyasova MS, et al. Clin Cancer Res. 2015 Apr 15;21(8):1789-94. doi: 10.1158/1078-0432.CCR-13-2490. Epub 2014 Dec 4. Clin Cancer Res. 2015. PMID: 25477533 Free PMC article. Review.
Mutations in Cbl that inactivate the negative E3 function while maintaining the positive adaptor function have been described in approximately 5% of myeloid neoplasms. ...Thus, targeting the pathways regulated by Cbl proteins may provide attractive opportunit …
Mutations in Cbl that inactivate the negative E3 function while maintaining the positive adaptor function have been described in appr …
[CBL inhibits proliferation and invasion of breast cancer cells by ubiquitylation-mediated degradation of NCK2].
Song X, Xiao B, Lu J, Zhang W, Li J, Zhu X, Sun Z, Li L. Song X, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Nov 20;42(11):1594-1603. doi: 10.12122/j.issn.1673-4254.2022.11.02. Nan Fang Yi Ke Da Xue Xue Bao. 2022. PMID: 36504051 Free PMC article. Chinese.
OBJECTIVE: To observe the effects of Casitas B lymphoma (CBL) protein on proliferation, migration and invasion of breast cancer cells and explore its mechanism of action. ...CONCLUSION: CBL can inhibit the proliferation, migration and invasion of breast ca …
OBJECTIVE: To observe the effects of Casitas B lymphoma (CBL) protein on proliferation, migration and invasion of breast cancer …
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Shen H, He M, Lin R, Zhan M, Xu S, Huang X, Xu C, Chen W, Yao Y, Mohan M, Wang J. Shen H, et al. J Exp Clin Cancer Res. 2019 Jun 10;38(1):247. doi: 10.1186/s13046-019-1250-8. J Exp Clin Cancer Res. 2019. PMID: 31182136 Free PMC article.
BACKGROUND: Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. ...RESULTS: In this study, we found that PLEK2 had higher expression in GBC tumor tissues compared to non-cancerous adjacent tissues and cholecystolithiasis tissues. The …
BACKGROUND: Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. ...RESULTS: In this study, we found …
Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status.
Schlicher L, Green LG, Romagnani A, Renner F. Schlicher L, et al. Front Immunol. 2023 Oct 31;14:1297175. doi: 10.3389/fimmu.2023.1297175. eCollection 2023. Front Immunol. 2023. PMID: 38022587 Free PMC article. Review.
In the adaptive immune system, negative regulators of T cell receptor signaling (MAP4K1, DGKalpha/zeta, CBL-B, PTPN2, PTPN22, SHP1), co-receptor signaling (CBL-B) and cytokine signaling (PTPN2) have been preclinically validated as promising targets and initial clini …
In the adaptive immune system, negative regulators of T cell receptor signaling (MAP4K1, DGKalpha/zeta, CBL-B, PTPN2, PTPN22, SHP1), …
Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
Wisniewski DJ, Liyasova MS, Korrapati S, Zhang X, Ratnayake S, Chen Q, Gilbert SF, Catalano A, Voeller D, Meerzaman D, Guha U, Porat-Shliom N, Annunziata CM, Lipkowitz S. Wisniewski DJ, et al. J Biol Chem. 2023 Jan;299(1):102766. doi: 10.1016/j.jbc.2022.102766. Epub 2022 Dec 5. J Biol Chem. 2023. PMID: 36470425 Free PMC article.
Epidermal growth factor receptor (EGFR) signaling is frequently dysregulated in various cancers. The ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene (Cbl) regulates degradation of activated EGFR through ubiquitination and acts as an adaptor to recruit pro …
Epidermal growth factor receptor (EGFR) signaling is frequently dysregulated in various cancers. The ubiquitin ligase Casitas B-linea …
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W. Zhou J, et al. Nat Immunol. 2021 Apr;22(4):460-470. doi: 10.1038/s41590-021-00888-3. Epub 2021 Mar 25. Nat Immunol. 2021. PMID: 33767425 Free PMC article.
Here, we report that mice with MDM2 deficiency in T cells exhibit accelerated tumor progression and a decrease in tumor-infiltrating CD8(+) T cell survival and function. Mechanistically, MDM2 competes with c-Cbl for STAT5 binding, reduces c-Cbl-mediated STAT5 degrad …
Here, we report that mice with MDM2 deficiency in T cells exhibit accelerated tumor progression and a decrease in tumor-infiltrating CD8(+) …
1,534 results