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lncRNA XIST/miR-129-2-3p axis targets CCP110 to regulate the proliferation, invasion and migration of endometrial cancer cells.
Chen S, Liang Y, Shen Y, Wang X. Chen S, et al. Exp Ther Med. 2023 Feb 22;25(4):159. doi: 10.3892/etm.2023.11858. eCollection 2023 Apr. Exp Ther Med. 2023. PMID: 36911384 Free PMC article.
Centromere coiled-coil protein 110 (CCP110) plays a role in the development of several types of cancer; however, its regulatory mechanism and role in endometrial cancer is unclear. ...CCP110, XIST and miR-129-2-3p could represent novel targets for the …
Centromere coiled-coil protein 110 (CCP110) plays a role in the development of several types of cancer; however, its regulator …
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Xie S, Farmer T, Naslavsky N, Caplan S. Xie S, et al. J Cell Sci. 2019 Nov 14;132(22):jcs233973. doi: 10.1242/jcs.233973. J Cell Sci. 2019. PMID: 31615969 Free PMC article.
The endocytic protein EHD1 plays an important role in ciliogenesis by facilitating fusion of the ciliary vesicle and removal of CP110 (also known as CCP110) from the mother centriole, as well as removal of Cep215 (also known as CDK5RAP2) from centrioles to permit disengage …
The endocytic protein EHD1 plays an important role in ciliogenesis by facilitating fusion of the ciliary vesicle and removal of CP110 (also …
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R. Bozal-Basterra L, et al. Am J Hum Genet. 2018 Feb 1;102(2):249-265. doi: 10.1016/j.ajhg.2017.12.017. Am J Hum Genet. 2018. PMID: 29395072 Free PMC article.
By using proximity proteomics, we show that truncated SALL1 interacts with factors related to cilia function, including the negative regulators of ciliogenesis CCP110 and CEP97. This most likely contributes to more frequent cilia formation in TBS-derived fibroblasts, as we …
By using proximity proteomics, we show that truncated SALL1 interacts with factors related to cilia function, including the negative regulat …
Emerging insights into CP110 removal during early steps of ciliogenesis.
Xie S, Naslavsky N, Caplan S. Xie S, et al. J Cell Sci. 2024 Feb 15;137(4):jcs261579. doi: 10.1242/jcs.261579. Epub 2024 Feb 28. J Cell Sci. 2024. PMID: 38415788 Review.
Primary ciliogenesis is a tightly regulated process, and a central early regulatory step is the removal of a key mother centriole capping protein, CP110 (also known as CCP110). This uncapping allows vesicles docked on the distal appendages of the mother centriole to fuse t …
Primary ciliogenesis is a tightly regulated process, and a central early regulatory step is the removal of a key mother centriole capping pr …
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Xie S, Dierlam C, Smith E, Duran R, Williams A, Davis A, Mathew D, Naslavsky N, Iyer J, Caplan S. Xie S, et al. J Cell Sci. 2022 May 15;135(10):jcs259396. doi: 10.1242/jcs.259396. Epub 2022 May 17. J Cell Sci. 2022. PMID: 35510502 Free PMC article.
Retromer also coimmunoprecipitated with the centriolar protein, CP110 (also known as CCP110), and was required for its removal from the mother centriole. ...
Retromer also coimmunoprecipitated with the centriolar protein, CP110 (also known as CCP110), and was required for its removal from t …
Pathway-specific effects of ADSL deficiency on neurodevelopment.
Dutto I, Gerhards J, Herrera A, Souckova O, Škopová V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikánová M, Pons S, Philipp M, Lüders J, Stracker TH. Dutto I, et al. Elife. 2022 Feb 8;11:e70518. doi: 10.7554/eLife.70518. Elife. 2022. PMID: 35133277 Free PMC article.
Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.
Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E. Danilov AV, et al. Mol Cancer Ther. 2016 Nov;15(11):2758-2766. doi: 10.1158/1535-7163.MCT-16-0127. Epub 2016 Aug 22. Mol Cancer Ther. 2016. PMID: 27550941 Free PMC article.
Despite advances in targeted therapy, lung cancer remains the most common cause of cancer-related mortality in the United States. ...Mol Cancer Ther; 15(11); 2758-66. 2016 AACR....
Despite advances in targeted therapy, lung cancer remains the most common cause of cancer-related mortality in the United Stat …
MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.
Zhang Y, Wang Y, Wei Y, Li M, Yu S, Ye M, Zhang H, Chen S, Liu W, Zhang J. Zhang Y, et al. Sci Rep. 2015 Oct 21;5:15424. doi: 10.1038/srep15424. Sci Rep. 2015. PMID: 26487539 Free PMC article.
The purpose of this study was to investigate the possible role of miR-129-3p in breast cancer cell resistance to docetaxel. MiR-129 and miR-129-3p inhibitor were transfected into breast cancer cells to investigate their effects on chemoresistance to docetaxel. ...Ou …
The purpose of this study was to investigate the possible role of miR-129-3p in breast cancer cell resistance to docetaxel. MiR-129 a …
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E. Hu S, et al. Cancer Res. 2015 May 15;75(10):2029-38. doi: 10.1158/0008-5472.CAN-14-1494. Epub 2015 Mar 25. Cancer Res. 2015. PMID: 25808870 Free PMC article.
Furthermore, activated KRAS mutations sensitized lung cancer cells to CDK2 inhibition by deregulating CP110 expression. ...Independent examination of murine and human paired normal-malignant lung tissues revealed marked upregulation of CP110 in malignant versus normal lung …
Furthermore, activated KRAS mutations sensitized lung cancer cells to CDK2 inhibition by deregulating CP110 expression. ...Independen …
miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110.
Bijnsdorp IV, Hodzic J, Lagerweij T, Westerman B, Krijgsman O, Broeke J, Verweij F, Nilsson RJ, Rozendaal L, van Beusechem VW, van Moorselaar JA, Wurdinger T, Geldof AA. Bijnsdorp IV, et al. Oncotarget. 2016 Mar 29;7(13):16676-87. doi: 10.18632/oncotarget.7572. Oncotarget. 2016. PMID: 26918338 Free PMC article.
The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. ...
The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulat …
27 results