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Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis.
Liu X, Wang X, Yang Q, Luo L, Liu Z, Ren X, Lei K, Li S, Xie Z, Zheng G, Zhang Y, Hao Y, Zhou Q, Hou Y, Fang F, Song W, Cui J, Ma J, Xie W, Shen S, Tang C, Peng S, Yu J, Kuang M, Song X, Wang F, Xu L. Liu X, et al. Cancer Res. 2024 Apr 15;84(8):1352-1371. doi: 10.1158/0008-5472.CAN-23-2123. Cancer Res. 2024. PMID: 38335276
Single-cell RNA sequencing analysis revealed distinct distributions of nonmalignant cells between primary tumors from patients with metastatic colorectal cancer (mCRC) and non-metastatic colorectal cancer, showing that Th17 cells were predominantly enriched in the p …
Single-cell RNA sequencing analysis revealed distinct distributions of nonmalignant cells between primary tumors from patients with metastat …
Mutation Drivers of Immunological Responses to Cancer.
Porta-Pardo E, Godzik A. Porta-Pardo E, et al. Cancer Immunol Res. 2016 Sep 2;4(9):789-98. doi: 10.1158/2326-6066.CIR-15-0233. Epub 2016 Jul 11. Cancer Immunol Res. 2016. PMID: 27401919 Free PMC article.
Identifying these genes and mechanisms is important because, just as the identification of cancer driver genes led to the development of personalized cancer therapies, a comprehensive catalog of such cancer immunity drivers will aid in the development of ther …
Identifying these genes and mechanisms is important because, just as the identification of cancer driver genes led to the development …
Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer.
Yu X, Teng Y, Jiang X, Yuan H, Jiang W. Yu X, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820983793. doi: 10.1177/1533033820983793. Technol Cancer Res Treat. 2020. PMID: 33357046 Free PMC article.
BACKGROUND: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. ...Sphere-forming cells were collected from human primary esophageal cancer cells. SP cells and …
BACKGROUND: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is …
CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo.
González-Domínguez É, Samaniego R, Flores-Sevilla JL, Campos-Campos SF, Gómez-Campos G, Salas A, Campos-Peña V, Corbí ÁL, Sánchez-Mateos P, Sánchez-Torres C. González-Domínguez É, et al. J Leukoc Biol. 2015 Oct;98(4):453-66. doi: 10.1189/jlb.3HI1114-531R. Epub 2015 Apr 15. J Leukoc Biol. 2015. PMID: 25877931
We found selective expression of the lectin C-type lectin domain family 5 member A (CLEC5A) transcripts in GM-Ms and the scavenger receptor CD163 molecule-like 1 (CD163L1) in M-Ms by microarray assay. In vitro, CD163L1 expression was induced by IL-10 and M-CSF and C …
We found selective expression of the lectin C-type lectin domain family 5 member A (CLEC5A) transcripts in GM-Ms and the scavenger receptor …
Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers.
Zahra A, Rubab I, Malik S, Khan A, Khan MJ, Fatmi MQ. Zahra A, et al. Biomed Res Int. 2018 Jan 4;2018:8439820. doi: 10.1155/2018/8439820. eCollection 2018. Biomed Res Int. 2018. PMID: 29516011 Free PMC article.
Dysregulated expression of miRNAs is known to affect cell growth, and these may function as tumor suppressors or oncogenes in various cancers. The main objective of this study was to characterize the extracellular miRNAs involved in oral cancer (OC) that can potenti …
Dysregulated expression of miRNAs is known to affect cell growth, and these may function as tumor suppressors or oncogenes in various can …
Aperture Modulation of Isoreticular Metal Organic Frameworks for Targeted Antitumor Drug Delivery.
Cai M, Liang W, Wang K, Yin D, Fu T, Zhu R, Qu C, Dong X, Ni J, Yin X. Cai M, et al. ACS Appl Mater Interfaces. 2022 Aug 17;14(32):36366-36378. doi: 10.1021/acsami.2c07450. Epub 2022 Jul 27. ACS Appl Mater Interfaces. 2022. PMID: 35897121
IRMOF-1 was further coated with polyethylene glycol (PEG) modified with a cell penetrating peptide (CPP44) bound to M160 (CD163L1) protein for targeting of hepatic tumor lines. This nanoplatform (CPP44-PEG@ORI@IRMOF-1) exhibited acid-responsive drug release behavior (37.86 …
IRMOF-1 was further coated with polyethylene glycol (PEG) modified with a cell penetrating peptide (CPP44) bound to M160 (CD163L1) pr …
Increased circulating M2-like monocytes in patients with breast cancer.
Zhang B, Cao M, He Y, Liu Y, Zhang G, Yang C, Du Y, Xu J, Hu J, Gao F. Zhang B, et al. Tumour Biol. 2017 Jun;39(6):1010428317711571. doi: 10.1177/1010428317711571. Tumour Biol. 2017. PMID: 28639912 Free article.
However, the frequency of circulating M2-like monocytes in the peripheral blood of breast cancer patients has not been clarified. The objective of this study was to determine the percentages of circulating M2-like monocytes in patients with breast cancer. ...Circula …
However, the frequency of circulating M2-like monocytes in the peripheral blood of breast cancer patients has not been clarified. The …