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1987 1
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1990 2
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1996 2
1997 1
1999 1
2000 1
2001 1
2002 2
2003 2
2004 3
2005 1
2006 1
2007 4
2008 1
2009 1
2010 3
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2012 2
2013 1
2014 1
2015 3
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75 results

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Page 1
Prognostic Value of CD1B in Localised Prostate Cancer.
Lee CH, Chen LC, Yu CC, Lin WH, Lin VC, Huang CY, Lu TL, Huang SP, Bao BY. Lee CH, et al. Int J Environ Res Public Health. 2019 Nov 27;16(23):4723. doi: 10.3390/ijerph16234723. Int J Environ Res Public Health. 2019. PMID: 31783478 Free PMC article.
In addition, rs3181082 overlapped with predicted transcriptional regulatory elements and affected CD1B expression. Furthermore, low CD1B expression correlated with poorer BCR-free survival. Our results indicated that CD1B rs3181082 confers prostate cancer …
In addition, rs3181082 overlapped with predicted transcriptional regulatory elements and affected CD1B expression. Furthermore, low …
The intricacies of self-lipid antigen presentation by CD1b.
Shahine A. Shahine A. Mol Immunol. 2018 Dec;104:27-36. doi: 10.1016/j.molimm.2018.09.022. Epub 2018 Nov 3. Mol Immunol. 2018. PMID: 30399491 Free article. Review.
Humans express three classes of CD1 molecules, denoted as Group 1 (CD1a, CD1b, and CD1c), Group 2 (CD1d), and Group 3 (CD1e). Of the CD1 family of molecules, CD1b exhibits the largest and most complex antigen binding groove; allowing it the capabilities to present a …
Humans express three classes of CD1 molecules, denoted as Group 1 (CD1a, CD1b, and CD1c), Group 2 (CD1d), and Group 3 (CD1e). Of the …
Human gammadelta T cells recognize CD1b by two distinct mechanisms.
Reijneveld JF, Ocampo TA, Shahine A, Gully BS, Vantourout P, Hayday AC, Rossjohn J, Moody DB, Van Rhijn I. Reijneveld JF, et al. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22944-22952. doi: 10.1073/pnas.2010545117. Epub 2020 Aug 31. Proc Natl Acad Sci U S A. 2020. PMID: 32868441 Free PMC article.
Using CD1b tetramers to study multiple donors, we found that many CD1b-specific gammadelta T cells use Vdelta1. ...Several Vgamma segments were present among the CD1b-specific TCRs, but chain swap experiments demonstrated that CD1b specificity was medi …
Using CD1b tetramers to study multiple donors, we found that many CD1b-specific gammadelta T cells use Vdelta1. ...Several Vga …
Human autoreactive T cells recognize CD1b and phospholipids.
Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB. Van Rhijn I, et al. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30. Proc Natl Acad Sci U S A. 2016. PMID: 26621732 Free PMC article.
Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors. Activation is mediated by alphabeta T-cell receptors (TCRs) binding to CD1b …
Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in iden …
CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.
James CA, Xu Y, Aguilar MS, Jing L, Layton ED, Gilleron M, Minnaard AJ, Scriba TJ, Day CL, Warren EH, Koelle DM, Seshadri C. James CA, et al. Nat Commun. 2022 Jan 10;13(1):78. doi: 10.1038/s41467-021-27764-w. Nat Commun. 2022. PMID: 35013257 Free PMC article.
T cells recognize mycobacterial glycolipid (mycolipid) antigens presented by CD1b molecules, but the role of CD4 and CD8 co-receptors in mycolipid recognition is unknown. ...CD4+ primary T cells transduced with mycolipid-specific T cell receptors bind CD1b-mycolipid …
T cells recognize mycobacterial glycolipid (mycolipid) antigens presented by CD1b molecules, but the role of CD4 and CD8 co-receptors …
Cancer Stemness-Based Prognostic Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.
Li N, Li Y, Zheng P, Zhan X. Li N, et al. Front Endocrinol (Lausanne). 2021 Oct 21;12:755805. doi: 10.3389/fendo.2021.755805. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34745015 Free PMC article.
BACKGROUND: Cancer stem cells (CSCs) refer to cells with self-renewal capability in tumors. ...Evaluation of integrative characterization of multiple immune-related genes and pathways could help to understand the association between cancer stemness and tumor microen …
BACKGROUND: Cancer stem cells (CSCs) refer to cells with self-renewal capability in tumors. ...Evaluation of integrative characteriza …
CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.
Chancellor A, Tocheva AS, Cave-Ayland C, Tezera L, White A, Al Dulayymi JR, Bridgeman JS, Tews I, Wilson S, Lissin NM, Tebruegge M, Marshall B, Sharpe S, Elliott T, Skylaris CK, Essex JW, Baird MS, Gadola S, Elkington P, Mansour S. Chancellor A, et al. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10956-E10964. doi: 10.1073/pnas.1708252114. Epub 2017 Nov 20. Proc Natl Acad Sci U S A. 2017. PMID: 29158404 Free PMC article.
Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted and recognize CD1b-presented mycobacterial mycolates. However, the molecular requirements governing mycolate antigenicity for the GEM T cell receptor (TCR) remain poorly understood. Here, we demon …
Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted and recognize CD1b-presented mycobacterial mycolates. Ho …
Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination.
Layton ED, Yu KKQ, Smith MT, Scriba TJ, De Rosa SC, Seshadri C. Layton ED, et al. J Immunol Methods. 2018 Jul;458:44-52. doi: 10.1016/j.jim.2018.04.004. Epub 2018 Apr 21. J Immunol Methods. 2018. PMID: 29684428 Free PMC article.
However, there are no standardized assays to quantify and characterize lipid antigen-specific T cells present within clinical samples. We incorporated CD1b tetramers loaded with the mycobacterial lipid glucose monomycolate (GMM) into a multi-parameter flow cytometry assay. …
However, there are no standardized assays to quantify and characterize lipid antigen-specific T cells present within clinical samples. We in …
Exploiting CD1-restricted T cells for clinical benefit.
Exley MA, Dellabona P, Casorati G. Exley MA, et al. Mol Immunol. 2021 Apr;132:126-131. doi: 10.1016/j.molimm.2020.12.015. Epub 2021 Feb 12. Mol Immunol. 2021. PMID: 33582549 Review.
The development of highly-specific methods of isolating, stimulating, expanding or depleting these relatively rare cells and controlling their potent activities has stimulated considerable interest in therapeutic targeting of iNKT cells. Potential applications include cancers …
The development of highly-specific methods of isolating, stimulating, expanding or depleting these relatively rare cells and controlling the …
Genomic landscape of the immune microenvironments of brain metastases in breast cancer.
Lu WC, Xie H, Yuan C, Li JJ, Li ZY, Wu AH. Lu WC, et al. J Transl Med. 2020 Aug 31;18(1):327. doi: 10.1186/s12967-020-02503-9. J Transl Med. 2020. PMID: 32867782 Free PMC article.
Total 42 immune-related genes were identified, such as THY1 and NEU2. CD1B, THY1 and DOCK2 were found to be implicated in the metastatic recurrence of breast cancer. CONCLUSIONS: Targeting macrophages or plasma cells may be new strategies for immunotherapy of breast …
Total 42 immune-related genes were identified, such as THY1 and NEU2. CD1B, THY1 and DOCK2 were found to be implicated in the metasta …
75 results