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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
1991 3
1992 6
1993 4
1994 8
1995 1
1996 3
1997 4
1998 4
1999 5
2000 4
2001 5
2002 2
2003 4
2004 9
2005 8
2006 9
2007 8
2008 7
2009 15
2010 13
2011 17
2012 31
2013 32
2014 32
2015 33
2016 32
2017 32
2018 32
2019 40
2020 54
2021 57
2022 59
2023 63
2024 43

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614 results

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Page 1
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.
Elyada E, Bolisetty M, Laise P, Flynn WF, Courtois ET, Burkhart RA, Teinor JA, Belleau P, Biffi G, Lucito MS, Sivajothi S, Armstrong TD, Engle DD, Yu KH, Hao Y, Wolfgang CL, Park Y, Preall J, Jaffee EM, Califano A, Robson P, Tuveson DA. Elyada E, et al. Cancer Discov. 2019 Aug;9(8):1102-1123. doi: 10.1158/2159-8290.CD-19-0094. Epub 2019 Jun 13. Cancer Discov. 2019. PMID: 31197017 Free PMC article.
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). ...Moreover, we describe a new population of CAFs that express MHC class II and CD74, but do not express classic costimulatory mo …
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDA …
Role of MIF1/MIF2/CD74 interactions in bladder cancer.
Woolbright BL, Rajendran G, Abbott E, Martin A, Amalraj S, Dennis K, Li X, Warrick J, Taylor JA 3rd. Woolbright BL, et al. J Pathol. 2023 Jan;259(1):46-55. doi: 10.1002/path.6018. Epub 2022 Nov 9. J Pathol. 2023. PMID: 36214539 Free PMC article.
Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in inflammation and cancer. Genetic knockout of Mif1 in the validated N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) model of bladder cancer (BCa) resulted in stage arrest at non-muscle-i …
Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in inflammation and cancer. Genetic knockout of Mif1 …
Bioinformatics reveal macrophages marker genes signature in breast cancer to predict prognosis.
Li Y, Zhao X, Liu Q, Liu Y. Li Y, et al. Ann Med. 2021 Dec;53(1):1019-1031. doi: 10.1080/07853890.2021.1914343. Ann Med. 2021. PMID: 34187256 Free PMC article.
Background: Breast cancer is a pivotal cause of global women cancer death. Immunotherapy has become a promising means to cure breast cancer. As constitutes of immune microenvironment of breast cancer, macrophages exert complicated functions in the tumo …
Background: Breast cancer is a pivotal cause of global women cancer death. Immunotherapy has become a promising means to cure …
NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents.
Laskin J, Liu SV, Tolba K, Heining C, Schlenk RF, Cheema P, Cadranel J, Jones MR, Drilon A, Cseh A, Gyorffy S, Solca F, Duruisseaux M. Laskin J, et al. Ann Oncol. 2020 Dec;31(12):1693-1703. doi: 10.1016/j.annonc.2020.08.2335. Epub 2020 Sep 9. Ann Oncol. 2020. PMID: 32916265 Free PMC article. Review.
Fusions involving the neuregulin-1 gene (NRG1) result in ErbB-mediated pathway activation and therefore present a rational candidate for targeted treatment. The most frequently reported NRG1 fusion is CD74-NRG1, which most commonly occurs in patients with invasive mucinous …
Fusions involving the neuregulin-1 gene (NRG1) result in ErbB-mediated pathway activation and therefore present a rational candidate for tar …
CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease.
Borghese F, Clanchy FI. Borghese F, et al. Expert Opin Ther Targets. 2011 Mar;15(3):237-51. doi: 10.1517/14728222.2011.550879. Epub 2011 Jan 6. Expert Opin Ther Targets. 2011. PMID: 21208136 Review.
The role of CD74 signaling in inflammatory and carcinogenic processes is outlined as is the use of CD74 as a therapeutic target (in cancer) and tool (as a vaccine). EXPERT OPINION: CD74 has several roles within the cell and throughout the immune system …
The role of CD74 signaling in inflammatory and carcinogenic processes is outlined as is the use of CD74 as a therapeutic targe …
CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis.
Loreth D, Schuette M, Zinke J, Mohme M, Piffko A, Schneegans S, Stadler J, Janning M, Loges S, Joosse SA, Lamszus K, Westphal M, Müller V, Glatzel M, Matschke J, Gebhardt C, Schneider SW, Belczacka I, Volkmer B, Greinert R, Yaspo ML, Harter PN, Pantel K, Wikman H. Loreth D, et al. Int J Mol Sci. 2021 Jun 29;22(13):6993. doi: 10.3390/ijms22136993. Int J Mol Sci. 2021. PMID: 34209696 Free PMC article.
CTCs were found in 50% (7/14) of breast cancer, 50% (9/18) of non-small cell lung cancer (NSCLC) and 36% (4/11) of melanoma patients. ...CD44 and CD74 were expressed on most CTCs and their expression was strongly correlated, whereas matched breast cancer …
CTCs were found in 50% (7/14) of breast cancer, 50% (9/18) of non-small cell lung cancer (NSCLC) and 36% (4/11) of melanoma pa …
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.
Gil Del Alcazar CR, Trinh A, Alečković M, Rojas Jimenez E, Harper NW, Oliphant MUJ, Xie S, Krop ED, Lulseged B, Murphy KC, Keenan TE, Van Allen EM, Tolaney SM, Freeman GJ, Dillon DA, Muthuswamy SK, Polyak K. Gil Del Alcazar CR, et al. Cancer Immunol Res. 2022 Jun 3;10(6):680-697. doi: 10.1158/2326-6066.CIR-21-0804. Cancer Immunol Res. 2022. PMID: 35446942 Free PMC article.
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models do not faithfully reproduce the molecular subtypes and immune environment of the human disease. ...We found that the expression of CD74 …
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models …
Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer.
Kashima Y, Shibahara D, Suzuki A, Muto K, Kobayashi IS, Plotnick D, Udagawa H, Izumi H, Shibata Y, Tanaka K, Fujii M, Ohashi A, Seki M, Goto K, Tsuchihara K, Suzuki Y, Kobayashi SS. Kashima Y, et al. Cancer Res. 2021 Sep 15;81(18):4835-4848. doi: 10.1158/0008-5472.CAN-20-2811. Epub 2021 Jul 9. Cancer Res. 2021. PMID: 34247147 Free PMC article.
In addition to AURKA, VIM, and AXL, which are all known to induce EGFR-TKI resistance, CD74 was identified as a novel gene that plays a critical role in the drug-tolerant state. In vitro and in vivo experiments demonstrated that CD74 upregulation confers resistance …
In addition to AURKA, VIM, and AXL, which are all known to induce EGFR-TKI resistance, CD74 was identified as a novel gene that plays …
CD74 Promotes a Pro-Inflammatory Tumor Microenvironment by Inducing S100A8 and S100A9 Secretion in Pancreatic Cancer.
Hong WC, Lee DE, Kang HW, Kim MJ, Kim M, Kim JH, Fang S, Kim HJ, Park JS. Hong WC, et al. Int J Mol Sci. 2023 Aug 20;24(16):12993. doi: 10.3390/ijms241612993. Int J Mol Sci. 2023. PMID: 37629174 Free PMC article.
The receptor CD74 was recently identified as a regulator of oncogenic properties in various cancers. However, the precise molecular mechanism of CD74 action in PDAC remains little understood. We investigated the role of CD74 by silencing CD74 in …
The receptor CD74 was recently identified as a regulator of oncogenic properties in various cancers. However, the precise mole …
CD74 promotes perineural invasion of cancer cells and mediates neuroplasticity via the AKT/EGR-1/GDNF axis in pancreatic ductal adenocarcinoma.
Zhang JF, Tao LY, Yang MW, Xu DP, Jiang SH, Fu XL, Liu DJ, Huo YM, Liu W, Yang JY, Hua R, Lu P, Sun YW. Zhang JF, et al. Cancer Lett. 2021 Jun 28;508:47-58. doi: 10.1016/j.canlet.2021.03.016. Epub 2021 Mar 22. Cancer Lett. 2021. PMID: 33766751
Then the in vivo PNI model, in vitro neuroplasticity assay, cell proliferation assay, wound healing and Transwell-based invasion assay were performed to examine the function of CD74 in pancreatic cancer cell lines. ChIP assay and Luciferase reporter assay were used …
Then the in vivo PNI model, in vitro neuroplasticity assay, cell proliferation assay, wound healing and Transwell-based invasion assay were …
614 results