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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1993 1
1994 4
1995 7
1996 11
1997 30
1998 31
1999 38
2000 46
2001 55
2002 67
2003 71
2004 93
2005 70
2006 86
2007 84
2008 89
2009 100
2010 99
2011 113
2012 125
2013 158
2014 139
2015 122
2016 153
2017 155
2018 124
2019 125
2020 162
2021 141
2022 122
2023 100
2024 43

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2,464 results

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Page 1
Molecular subversion of Cdc42 signalling in cancer.
Murphy NP, Binti Ahmad Mokhtar AM, Mott HR, Owen D. Murphy NP, et al. Biochem Soc Trans. 2021 Jun 30;49(3):1425-1442. doi: 10.1042/BST20200557. Biochem Soc Trans. 2021. PMID: 34196668 Free PMC article. Review.
This has coincided with the introduction of new structural techniques with the ability to study small GTPases in the context of the membrane. The role of Cdc42 in cancer is well established but the molecular details of its action are still being uncovered. Here we r …
This has coincided with the introduction of new structural techniques with the ability to study small GTPases in the context of the membrane …
Cdc42: Role in Cancer Management.
Qadir MI, Parveen A, Ali M. Qadir MI, et al. Chem Biol Drug Des. 2015 Oct;86(4):432-9. doi: 10.1111/cbdd.12556. Epub 2015 Apr 7. Chem Biol Drug Des. 2015. PMID: 25777055 Review.
Deregulation of Cdc42 can alter the normal functioning of the cells, responsible for the initiation of signaling pathways and is correlated with several pathogenic processes such as cancer. ...Therefore, it can be suggested that deeper understanding about the Cdc …
Deregulation of Cdc42 can alter the normal functioning of the cells, responsible for the initiation of signaling pathways and is corr …
Targeting Rac and Cdc42 GTPases in Cancer.
Maldonado MDM, Dharmawardhane S. Maldonado MDM, et al. Cancer Res. 2018 Jun 15;78(12):3101-3111. doi: 10.1158/0008-5472.CAN-18-0619. Epub 2018 Jun 1. Cancer Res. 2018. PMID: 29858187 Free PMC article. Review.
With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexpressed (gene amplification and mRNA upregulation) or hyperactivated. ...Hence, targeting Rac and Cdc42 represents a promising strateg …
With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexp …
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs.
Zhang Y, Li J, Lai XN, Jiao XQ, Xiong JP, Xiong LX. Zhang Y, et al. Cells. 2019 Feb 11;8(2):146. doi: 10.3390/cells8020146. Cells. 2019. PMID: 30754684 Free PMC article. Review.
Targeting Cdc42 also provides a strategy for precise breast cancer therapy. ...Here, we focus on the role of Cdc42 in cell morphogenesis, proliferation, motility, angiogenesis and survival, introduce the Cdc42-targeted non-coding RNAs, as well as prese …
Targeting Cdc42 also provides a strategy for precise breast cancer therapy. ...Here, we focus on the role of Cdc42 in c …
Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion.
Chernichenko N, Omelchenko T, Deborde S, Bakst RL, He S, Chen CH, Gusain L, Vakiani E, Katabi N, Hall A, Wong RJ. Chernichenko N, et al. Mol Cancer Res. 2020 Jun;18(6):913-925. doi: 10.1158/1541-7786.MCR-19-0726. Epub 2020 Feb 21. Mol Cancer Res. 2020. PMID: 32086369 Free PMC article.
Depletion of Cdc42 impairs pancreatic cancer cell chemotaxis toward GDNF and nerves. ...Activated Cdc42 is expressed in human salivary ductal cancer cells invading nerves. ...
Depletion of Cdc42 impairs pancreatic cancer cell chemotaxis toward GDNF and nerves. ...Activated Cdc42 is expressed in …
Targeting Cdc42 in cancer.
Arias-Romero LE, Chernoff J. Arias-Romero LE, et al. Expert Opin Ther Targets. 2013 Nov;17(11):1263-73. doi: 10.1517/14728222.2013.828037. Epub 2013 Aug 19. Expert Opin Ther Targets. 2013. PMID: 23957315 Free PMC article. Review.
Rho GTPases function as molecular switches in which the GTP-bound proteins are active and GDP-bound proteins are inactive. This article will focus on one Rho family member, Cdc42, which is overexpressed in a number of human cancers, and which might provide new thera …
Rho GTPases function as molecular switches in which the GTP-bound proteins are active and GDP-bound proteins are inactive. This article will …
Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
Xiao XH, Lv LC, Duan J, Wu YM, He SJ, Hu ZZ, Xiong LX. Xiao XH, et al. Molecules. 2018 Mar 29;23(4):787. doi: 10.3390/molecules23040787. Molecules. 2018. PMID: 29596304 Free PMC article. Review.
Moreover, recent studies show that in most human cancers Cdc42 is abnormally expressed and promoting neoplastic growth and metastasis. Regarding possible new treatments for cancer, miRNA and small molecules targeting Cdc42 and related pathways have bee …
Moreover, recent studies show that in most human cancers Cdc42 is abnormally expressed and promoting neoplastic growth and met …
Mechanistic Understanding of Curcumin's Therapeutic Effects in Lung Cancer.
Wan Mohd Tajuddin WNB, Lajis NH, Abas F, Othman I, Naidu R. Wan Mohd Tajuddin WNB, et al. Nutrients. 2019 Dec 6;11(12):2989. doi: 10.3390/nu11122989. Nutrients. 2019. PMID: 31817718 Free PMC article. Review.
Lung cancer is among the most common cancers with a high mortality rate worldwide. ...It has been shown that curcumin demonstrates anti-cancer effects in lung cancer through various mechanisms, including inhibition of cell proliferation, invasion, and …
Lung cancer is among the most common cancers with a high mortality rate worldwide. ...It has been shown that curcumin demonstr …
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Hodder S, Fox M, Binti Ahmad Mokhtar AM, Mott HR, Owen D. Hodder S, et al. Small GTPases. 2023 Dec;14(1):14-25. doi: 10.1080/21541248.2023.2212573. Small GTPases. 2023. PMID: 37194323 Free PMC article. Review.
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ACK is emerging as an important component of the cancer landscape and thus, a promising target for the treatment of many malignancies. ...
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine kinase, is an effector for the small GTPase Cdc42. ACK is eme …
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.
Hu X, Ma Z, Xu B, Li S, Yao Z, Liang B, Wang J, Liao W, Lin L, Wang C, Zheng S, Wu Q, Huang Q, Yu L, Wang F, Shi M. Hu X, et al. Cancer Commun (Lond). 2023 Aug;43(8):909-937. doi: 10.1002/cac2.12459. Epub 2023 Jul 11. Cancer Commun (Lond). 2023. PMID: 37434399 Free PMC article.
BACKGROUND: Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2 (HER2)-positive gastric cancer. However, the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit, and there is currently no effective reversal …
BACKGROUND: Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2 (HER2)-positive gastric cancer. …
2,464 results