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Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK.
Wu Q, Ma X, Jin Z, Ni R, Pan Y, Yang G. Wu Q, et al. J Ethnopharmacol. 2023 Oct 28;315:116644. doi: 10.1016/j.jep.2023.116644. Epub 2023 May 16. J Ethnopharmacol. 2023. PMID: 37196814
However, the mechanism by which the three compounds inhibit triple-negative breast cancer (TNBC) metastasis is unknown. OBJECTIVE: The objective of this investigation was to examine the inhibitory essences of ZDF on the metastasis of TNBC and elucidate its potential mechan …
However, the mechanism by which the three compounds inhibit triple-negative breast cancer (TNBC) metastasis is unknown. OBJECTIVE: Th …
MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
Kwa MQ, Brandao R, Phung TH, Ge J, Scieri G, Brakebusch C. Kwa MQ, et al. Cells. 2021 Apr 19;10(4):942. doi: 10.3390/cells10040942. Cells. 2021. PMID: 33921698 Free PMC article.
Assessing breast cancer development using the transgenic MMTV-PyMT mouse model, loss of MRCKalpha did not affect tumor onset, tumor growth and metastasis formation. ...Collectively, these data suggest that MRCKalpha might be a prognostic marker for breast cancer, bu …
Assessing breast cancer development using the transgenic MMTV-PyMT mouse model, loss of MRCKalpha did not affect tumor onset, tumor g …
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis.
Li J, Wang F, Li Z, Feng J, Men Y, Han J, Xia J, Zhang C, Han Y, Chen T, Zhao Y, Zhou S, Da Y, Chai G, Hao J. Li J, et al. J Transl Med. 2024 Mar 24;22(1):302. doi: 10.1186/s12967-024-04994-2. J Transl Med. 2024. PMID: 38521921 Free PMC article.
RESULTS: We identified significant MR results for four genes (CDC42BPB, CD226, PRSS36, and TNFSF12) using cis-eQTL genetic instruments and three proteins (CTSH, PRSS8, and CPN2) using cis-pQTL genetic instruments. ...
RESULTS: We identified significant MR results for four genes (CDC42BPB, CD226, PRSS36, and TNFSF12) using cis-eQTL genetic instrument …
Mendelian randomization and colocalization analysis reveal novel drug targets for myasthenia gravis.
Ouyang Y, Chen Y, Chen K, Tang Z, Shi G, Qu C, Zhang K, Yang H. Ouyang Y, et al. Hum Genomics. 2024 Apr 24;18(1):43. doi: 10.1186/s40246-024-00607-7. Hum Genomics. 2024. PMID: 38659056 Free PMC article.
RESULTS: The eQTL MR analysis has identified eight potential targets for MG, one for early-onset MG and seven for late-onset MG. Further colocalization analyses indicated that CD226, CDC42BPB, PRSS36, and TNFSF12 possess evidence for colocalization with MG or late-onset MG …
RESULTS: The eQTL MR analysis has identified eight potential targets for MG, one for early-onset MG and seven for late-onset MG. Further col …
A novel fusion between CDC42BPB and ALK in a patient with quadruple wild-type gastrointestinal stromal tumor.
Huang W, Yuan W, Ren L, Xu C, Luo R, Zhou Y, Lu W, Hao Q, Xu M, Hou Y. Huang W, et al. Mol Genet Genomic Med. 2022 May;10(5):e1881. doi: 10.1002/mgg3.1881. Epub 2022 Mar 23. Mol Genet Genomic Med. 2022. PMID: 35319816 Free PMC article.
METHODS: The DNA/RNA samples were detected using the NGS-based YuanSu450 gene panel. After identifying the CDC42BPB-ALK fusion by NGS, this novel fusion was further confirmed by Sanger sequencing. ...CONCLUSION: We unexpectedly found that this GIST patient showed ALK (D5F3 …
METHODS: The DNA/RNA samples were detected using the NGS-based YuanSu450 gene panel. After identifying the CDC42BPB-ALK fusion by NGS …
Bladder cancer risk stratification using a urinary mRNA biomarker panel - A path towards cystoscopy triaging.
Shkolyar E, Zhao Q, Mach KE, Teslovich NC, Lee TJ, Cox S, Skinner EC, Lu Y, Liao JC. Shkolyar E, et al. Urol Oncol. 2021 Aug;39(8):497.e9-497.e15. doi: 10.1016/j.urolonc.2021.02.011. Epub 2021 Mar 22. Urol Oncol. 2021. PMID: 33766467
OBJECTIVES: The risk of bladder cancer (BCa) diagnosis and recurrence necessitates cystoscopy. Improved risk stratification may inform personalized triage and surveillance strategies. ...Subjects with intermediate and high-risk BCa based on American Urological Association …
OBJECTIVES: The risk of bladder cancer (BCa) diagnosis and recurrence necessitates cystoscopy. Improved risk stratification may infor …
Deep Sequencing of Urinary RNAs for Bladder Cancer Molecular Diagnostics.
Sin MLY, Mach KE, Sinha R, Wu F, Trivedi DR, Altobelli E, Jensen KC, Sahoo D, Lu Y, Liao JC. Sin MLY, et al. Clin Cancer Res. 2017 Jul 15;23(14):3700-3710. doi: 10.1158/1078-0432.CCR-16-2610. Epub 2017 Feb 13. Clin Cancer Res. 2017. PMID: 28193625 Free PMC article.
Purpose: The majority of bladder cancer patients present with localized disease and are managed by transurethral resection. ...The model was further validated in an independent cohort of 101 urines.Results: A total of 418 genes were found to be differentially expressed bet …
Purpose: The majority of bladder cancer patients present with localized disease and are managed by transurethral resection. ...The mo …
Helicobacter pylori-induced gastric cancer is orchestrated by MRCKbeta-mediated Siah2 phosphorylation.
Dixit P, Kokate SB, Poirah I, Chakraborty D, Smoot DT, Ashktorab H, Rout N, Singh SP, Bhattacharyya A. Dixit P, et al. J Biomed Sci. 2021 Feb 3;28(1):12. doi: 10.1186/s12929-021-00710-0. J Biomed Sci. 2021. PMID: 33536006 Free PMC article.
The aim of this study was to evaluate Siah2 phosphorylation status under the influence of H. pylori infection and its impact in gastric cancer progression. METHODS: H. pylori-infected various GECs, gastric tissues from H. pylori-infected GC patients and H. felis-infected C …
The aim of this study was to evaluate Siah2 phosphorylation status under the influence of H. pylori infection and its impact in gastric c …
A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer.
Nagaraj SH, Reverter A. Nagaraj SH, et al. BMC Syst Biol. 2011 Feb 26;5:35. doi: 10.1186/1752-0509-5-35. BMC Syst Biol. 2011. PMID: 21352556 Free PMC article.
We introduce a systems biology approach to study cancer that formally integrates the available genetic, transcriptomic, epigenetic and molecular knowledge on cancer biology and, as a proof of concept, we apply it to colorectal cancer. ...CONCLUSION: We argue …
We introduce a systems biology approach to study cancer that formally integrates the available genetic, transcriptomic, epigenetic an …
A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Unbekandt M, Croft DR, Crighton D, Mezna M, McArthur D, McConnell P, Schüttelkopf AW, Belshaw S, Pannifer A, Sime M, Bower J, Drysdale M, Olson MF. Unbekandt M, et al. Cell Commun Signal. 2014 Oct 5;12:54. doi: 10.1186/s12964-014-0054-x. Cell Commun Signal. 2014. PMID: 25288205 Free PMC article.
BACKGROUND: The myotonic dystrophy kinase-related CDC42-binding kinases MRCKalpha and MRCKbeta regulate actin-myosin contractility and have been implicated in cancer metastasis. Along with the related ROCK1 and ROCK2 kinases, the MRCK proteins initiate signalling events th …
BACKGROUND: The myotonic dystrophy kinase-related CDC42-binding kinases MRCKalpha and MRCKbeta regulate actin-myosin contractility and have …
20 results