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2002 1
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Page 1
Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology.
Shen-Gunther J, Wang CM, Poage GM, Lin CL, Perez L, Banks NA, Huang TH. Shen-Gunther J, et al. Clin Epigenetics. 2016 Sep 13;8(1):96. doi: 10.1186/s13148-016-0263-9. eCollection 2016. Clin Epigenetics. 2016. PMID: 27651839 Free PMC article.
Independent validation of methylation profiles was performed by analyzing data from cervical cancer cell lines and clinical samples from The Cancer Genome Atlas (TCGA). ...CONCLUSIONS: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 are correlated …
Independent validation of methylation profiles was performed by analyzing data from cervical cancer cell lines and clinical samples f …
Molecular Pap Smear: Validation of HPV Genotype and Host Methylation Profiles of ADCY8, CDH8, and ZNF582 as a Predictor of Cervical Cytopathology.
Shen-Gunther J, Xia Q, Stacey W, Asusta HB. Shen-Gunther J, et al. Front Microbiol. 2020 Oct 15;11:595902. doi: 10.3389/fmicb.2020.595902. eCollection 2020. Front Microbiol. 2020. PMID: 33178175 Free PMC article.
This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the "Molecular Pap smear" based, on HPV genotype and ADCY8, CDH8 and ZNF582 CpG-methylation as a predictive classifier of cervical cytology. ...The proport …
This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the "Molecular Pap sme …
Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.
Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara KI, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A. Nakagawa T, et al. Cancer Lett. 2017 Oct 28;407:21-31. doi: 10.1016/j.canlet.2017.08.008. Epub 2017 Aug 18. Cancer Lett. 2017. PMID: 28823962
We performed genome-wide DNA methylation analysis using an Infinium 450k BeadArray for clinical OPSCC and non-cancerous samples and cancer cell lines with/without 5-aza-2'-deoxycytidine and/or trichostatin A treatment. Frequent promoter hypermethylation and methylat …
We performed genome-wide DNA methylation analysis using an Infinium 450k BeadArray for clinical OPSCC and non-cancerous samples and …
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.
Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Wagner AH, et al. Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9. Nat Commun. 2018. PMID: 30224629 Free PMC article.
Nearly all patients with small cell lung cancer (SCLC) eventually relapse with chemoresistant disease. The molecular mechanisms driving chemoresistance in SCLC remain un-characterized. ...
Nearly all patients with small cell lung cancer (SCLC) eventually relapse with chemoresistant disease. The molecular mechanisms drivi …
CHD8 is an independent prognostic indicator that regulates Wnt/beta-catenin signaling and the cell cycle in gastric cancer.
Sawada G, Ueo H, Matsumura T, Uchi R, Ishibashi M, Mima K, Kurashige J, Takahashi Y, Akiyoshi S, Sudo T, Sugimachi K, Doki Y, Mori M, Mimori K. Sawada G, et al. Oncol Rep. 2013 Sep;30(3):1137-42. doi: 10.3892/or.2013.2597. Epub 2013 Jul 8. Oncol Rep. 2013. PMID: 23835524
Previous studies suggest that CHD8 may negatively regulate various genes and signaling pathways, such as the Wnt/beta-catenin pathway. However, few studies have investigated the role of CHD8 in cancer cells. We analyzed the expression of CHD8 in cancer lesions and c …
Previous studies suggest that CHD8 may negatively regulate various genes and signaling pathways, such as the Wnt/beta-catenin pathway. Howev …
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.
Lu Y, Lemon W, Liu PY, Yi Y, Morrison C, Yang P, Sun Z, Szoke J, Gerald WL, Watson M, Govindan R, You M. Lu Y, et al. PLoS Med. 2006 Dec;3(12):e467. doi: 10.1371/journal.pmed.0030467. PLoS Med. 2006. PMID: 17194181 Free PMC article.
BACKGROUND: Lung cancer is the leading cause of cancer-related death in the United States. ...Of the 64 genes, 11 are related to cancer metastasis (APC, CDH8, IL8RB, LY6D, PCDHGA12, DSP, NID, ENPP2, CCR2, CASP8, and CASP10) and eight are involved in ap …
BACKGROUND: Lung cancer is the leading cause of cancer-related death in the United States. ...Of the 64 genes, 11 are related …
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
Lee Y, Yoon KA, Joo J, Lee D, Bae K, Han JY, Lee JS. Lee Y, et al. Carcinogenesis. 2013 Feb;34(2):307-13. doi: 10.1093/carcin/bgs356. Epub 2012 Nov 8. Carcinogenesis. 2013. PMID: 23144319
The prognostic significance of inherited genetic variants in advanced-stage non-small cell lung cancer (NSCLC) patients remains unknown. In this study, we genotyped 271 817 single-nucleotide polymorphisms in 348 advanced NSCLC patients who received chemotherapy and analyze …
The prognostic significance of inherited genetic variants in advanced-stage non-small cell lung cancer (NSCLC) patients remains unkno …
Meta-analysis of possible role of cadherin gene methylation in evolution and prognosis of hepatocellular carcinoma with a PRISMA guideline.
Zhu C, Feng X, Ye G, Huang T. Zhu C, et al. Medicine (Baltimore). 2017 Apr;96(16):e6650. doi: 10.1097/MD.0000000000006650. Medicine (Baltimore). 2017. PMID: 28422868 Free PMC article.
BACKGROUND: Cadherins (CDHs) have been reported to be associated with cancer. However, the clinical significance of CDH gene methylation in hepatocellular carcinoma (HCC) remains unclear. ...Methylated CDH13, PCDH10, CDH3, and CDH15, but not methylated CDH8 or CDH11 …
BACKGROUND: Cadherins (CDHs) have been reported to be associated with cancer. However, the clinical significance of CDH gene methylat …
Feasibility of methylated ctDNA detection in plasma samples of oropharyngeal squamous cell carcinoma patients.
de Jesus LM, Dos Reis MB, Carvalho RS, Scapulatempo Neto C, de Almeida GC, Laus AC, Marczynski GT, Leal LF, Melendez ME, de Marchi P, Manuel Reis R, Carvalho AL, de Carvalho AC. de Jesus LM, et al. Head Neck. 2020 Nov;42(11):3307-3315. doi: 10.1002/hed.26385. Epub 2020 Jul 20. Head Neck. 2020. PMID: 32687251
METHODS: Pretreatment formalin-fixed paraffin-embedded (FFPE) biopsies (n = 52) and paired plasma (n = 15) were tested for the methylation of CCNA1, DAPK, CDH8, and TIMP3 by droplet digital PCR (ddPCR). RESULTS: Seventy-one percent (37/52) of the biopsies showed methylatio …
METHODS: Pretreatment formalin-fixed paraffin-embedded (FFPE) biopsies (n = 52) and paired plasma (n = 15) were tested for the methylation o …
The CHD8 overgrowth syndrome: A detailed evaluation of an emerging overgrowth phenotype in 27 patients.
Ostrowski PJ, Zachariou A, Loveday C, Beleza-Meireles A, Bertoli M, Dean J, Douglas AGL, Ellis I, Foster A, Graham JM, Hague J, Hilhorst-Hofstee Y, Hoffer M, Johnson D, Josifova D, Kant SG, Kini U, Lachlan K, Lam W, Lees M, Lynch S, Maitz S, McKee S, Metcalfe K, Nathanson K, Ockeloen CW, Parker MJ, Pierson TM, Rahikkala E, Sanchez-Lara PA, Spano A, Van Maldergem L, Cole T, Douzgou S, Tatton-Brown K. Ostrowski PJ, et al. Am J Med Genet C Semin Med Genet. 2019 Dec;181(4):557-564. doi: 10.1002/ajmg.c.31749. Epub 2019 Nov 13. Am J Med Genet C Semin Med Genet. 2019. PMID: 31721432
17 results