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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 18
1995 103
1996 157
1997 265
1998 320
1999 359
2000 375
2001 404
2002 381
2003 339
2004 383
2005 356
2006 259
2007 234
2008 271
2009 273
2010 298
2011 283
2012 273
2013 286
2014 274
2015 296
2016 286
2017 265
2018 274
2019 244
2020 213
2021 219
2022 149
2023 142
2024 73

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7,402 results

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Page 1
Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting.
Hernández Borrero LJ, El-Deiry WS. Hernández Borrero LJ, et al. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556. doi: 10.1016/j.bbcan.2021.188556. Epub 2021 Apr 29. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33932560 Free PMC article. Review.
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. ...
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pa …
CDKN1A (p21 gene) polymorphisms correlates with age in esophageal cancer.
Kaya Z, Karan BM, Almalı N. Kaya Z, et al. Mol Biol Rep. 2022 Jan;49(1):249-258. doi: 10.1007/s11033-021-06865-1. Epub 2021 Nov 7. Mol Biol Rep. 2022. PMID: 34743275
BACKGROUND: CDKN1A gene encoding p21 is an important tumour supressor involved in the pathogenesis of cancers. A few studies have been devoted to the association between CDKN1A single nucleotide polymorphisms (SNPs) and esophageal cancer (EC) in China, …
BACKGROUND: CDKN1A gene encoding p21 is an important tumour supressor involved in the pathogenesis of cancers. A few studies h …
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL. Fan JH, et al. Phytomedicine. 2022 Feb;96:153881. doi: 10.1016/j.phymed.2021.153881. Epub 2021 Dec 9. Phytomedicine. 2022. PMID: 34942456
CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and …
CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, …
Expression of CDKN1A/p21 and TGFBR2 in breast cancer and their prognostic significance.
Wei CY, Tan QX, Zhu X, Qin QH, Zhu FB, Mo QG, Yang WP. Wei CY, et al. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14619-29. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26823785 Free PMC article.
BACKGROUND: A new diagnostic and prognostic biomarker may be of value in cancer diseases. Our study aimed to evaluate the CDKN1A/p21 and TGFBR2 level measurable in a cohort of patients with breast cancer after mastectomy, and to confirm their suitability to s …
BACKGROUND: A new diagnostic and prognostic biomarker may be of value in cancer diseases. Our study aimed to evaluate the CDKN1A …
Herba Patriniae and its component Isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation.
Li J, Shang L, Zhou F, Wang S, Liu N, Zhou M, Lin Q, Zhang M, Cai Y, Chen G, Yang S. Li J, et al. Biomed Pharmacother. 2023 Dec;168:115690. doi: 10.1016/j.biopha.2023.115690. Epub 2023 Nov 6. Biomed Pharmacother. 2023. PMID: 37939611 Free article.
Colorectal cancer (CRC) is the most prevalent cancer of the digestive tract. Herba Patriniae (also known as Bai Jiang Cao, HP) have been widely used to manage diarrhea, ulcerative colitis, and several cancers, including CRC. Nonetheless, the molecular mechani …
Colorectal cancer (CRC) is the most prevalent cancer of the digestive tract. Herba Patriniae (also known as Bai Jiang Cao, HP) …
Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway.
Feng R, Wang X, Chen H, Cao C, Liu T, Zhao T, Chen H, Tian R, Ni Y, Tian X, Hu Z, Ma J, Gong D. Feng R, et al. Curr Cancer Drug Targets. 2023;23(2):159-170. doi: 10.2174/1568009622666220822191039. Curr Cancer Drug Targets. 2023. PMID: 36017858
BACKGROUND: Chemotherapy is the common treatment for cervical cancer, and the occurrence of drug resistance seriously affects the therapeutic effect of cervical cancer. ...RESULTS: The expression of PRKD2 was higher in chemotherapy-resistant cervical cancer p …
BACKGROUND: Chemotherapy is the common treatment for cervical cancer, and the occurrence of drug resistance seriously affects the the …
Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer.
Alvizo-Rodríguez CR, Flores-López BA, Ayala-Madrigal ML, Partida-Pérez M, Macías-Gómez NM, Peregrina-Sandoval J, Suárez-Villanueva AS, Moreno-Ortiz JM, Cervantes-Ortiz S, Maciel-Gutiérre VM, Gutiérrez-Angulo M. Alvizo-Rodríguez CR, et al. Turk J Gastroenterol. 2022 Jun;33(6):525-531. doi: 10.5152/tjg.2022.21223. Turk J Gastroenterol. 2022. PMID: 35786622 Free PMC article.
BACKGROUND: Colorectal cancer is the second cause of death by cancer around the world. Sporadic colorectal cancer is the most frequent (75%), and it is produced by the interaction of environmental, epigenetic, and genetic factors. The accumulation of single-n …
BACKGROUND: Colorectal cancer is the second cause of death by cancer around the world. Sporadic colorectal cancer is th …
Clinical significance and functions of microRNA-93/CDKN1A axis in human cervical cancer.
Zhang X, Li F, Zhu L. Zhang X, et al. Life Sci. 2018 Sep 15;209:242-248. doi: 10.1016/j.lfs.2018.08.021. Epub 2018 Aug 8. Life Sci. 2018. PMID: 30098344
AIM: Accumulating studies have revealed that microRNA (miR)-93 may exert an oncogenic role in various cancers via inhibiting CDKN1A. However, the involvement of miR-93/CDKN1A axis in cervical cancer remains unclear. We aimed to investigate expression p …
AIM: Accumulating studies have revealed that microRNA (miR)-93 may exert an oncogenic role in various cancers via inhibiting CDKN1 …
LncRNA MSTO2P promotes colorectal cancer progression through epigenetically silencing CDKN1A mediated by EZH2.
Guo M, Zhang X. Guo M, et al. World J Surg Oncol. 2022 Mar 26;20(1):95. doi: 10.1186/s12957-022-02567-5. World J Surg Oncol. 2022. PMID: 35346226 Free PMC article.
BACKGROUND: Pseudogene-derived long non-coding RNAs (lncRNAs) have been reported to act as key regulatory factors of cancers. However, the study focused on pseudogene misato family member 2 (MSTO2P) in the occurrence and development of colorectal cancer (CRC) remain …
BACKGROUND: Pseudogene-derived long non-coding RNAs (lncRNAs) have been reported to act as key regulatory factors of cancers. However …
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M. Kobayashi T, et al. Sci Rep. 2022 Jul 1;12(1):11123. doi: 10.1038/s41598-022-15348-7. Sci Rep. 2022. PMID: 35778597 Free PMC article.
In this study, we aimed to investigate the anticancer effect of bexarotene and its underlying mechanism in ovarian cancer in vitro. The ES2 and NIH:OVACAR3 ovarian cancer cell lines were treated with 0, 5, 10, or 20 M of bexarotene. ...A clinical setting concentrati …
In this study, we aimed to investigate the anticancer effect of bexarotene and its underlying mechanism in ovarian cancer in vitro. T …
7,402 results