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2002 10
2003 26
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2,195 results

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Page 1
CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/beta-catenin signaling via transactivation of GSK-3beta and Axin2 expression.
Yu J, Liu D, Sun X, Yang K, Yao J, Cheng C, Wang C, Zheng J. Yu J, et al. Cell Death Dis. 2019 Jan 10;10(1):26. doi: 10.1038/s41419-018-1263-9. Cell Death Dis. 2019. PMID: 30631044 Free PMC article.
However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known. In this study, CDX2 knockdown in colon cancer cells promoted cell proliferation in vitro, accelerated tumor formation in vivo, and ind …
However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known. In this …
The prognostic potential of CDX2 in colorectal cancer: Harmonizing biology and clinical practice.
Badia-Ramentol J, Gimeno-Valiente F, Duréndez E, Martínez-Ciarpaglini C, Linares J, Iglesias M, Cervantes A, Calon A, Tarazona N. Badia-Ramentol J, et al. Cancer Treat Rev. 2023 Dec;121:102643. doi: 10.1016/j.ctrv.2023.102643. Epub 2023 Oct 12. Cancer Treat Rev. 2023. PMID: 37871463 Free article. Review.
CDX2 is a key transcription factor that controls intestinal fate. ...Finally, we attempt to clarify the molecular implications of CDX2 deficiency, ultimately providing insights for a more precise evaluation of CDX2 protein expression....
CDX2 is a key transcription factor that controls intestinal fate. ...Finally, we attempt to clarify the molecular implications of …
CDX2 Biomarker Testing and Adjuvant Therapy for Stage II Colon Cancer: An Exploratory Cost-Effectiveness Analysis.
Alarid-Escudero F, Schrag D, Kuntz KM. Alarid-Escudero F, et al. Value Health. 2022 Mar;25(3):409-418. doi: 10.1016/j.jval.2021.07.019. Epub 2021 Nov 2. Value Health. 2022. PMID: 35227453 Free PMC article.
METHODS: We developed a decision model to simulate a hypothetical cohort of 65-year-old patients with average-risk stage II colon cancer with 7.2% of these patients being CDX2-negative under 2 different interventions: (1) test for the absence of CDX2 expressi …
METHODS: We developed a decision model to simulate a hypothetical cohort of 65-year-old patients with average-risk stage II colon cancer …
The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.
Olsen J, Espersen ML, Jess P, Kirkeby LT, Troelsen JT. Olsen J, et al. Surg Oncol. 2014 Sep;23(3):167-76. doi: 10.1016/j.suronc.2014.07.003. Epub 2014 Jul 17. Surg Oncol. 2014. PMID: 25126956 Review.
CDX2 has been proposed as a tumor suppressor in colorectal cancer but its role is still controversial. ...CONCLUSION: A clear role for CDX2 expression in colorectal cancer remains to be elucidated, and it might differ in relation to the underlying mole …
CDX2 has been proposed as a tumor suppressor in colorectal cancer but its role is still controversial. ...CONCLUSION: A clear …
CDX2-positive breast cancer presented with axillary lymph node metastases: A case report.
Hoshina H, Takei H, Sakatani T, Naito Z. Hoshina H, et al. Cancer Treat Res Commun. 2021;26:100300. doi: 10.1016/j.ctarc.2020.100300. Epub 2020 Dec 29. Cancer Treat Res Commun. 2021. PMID: 33421821 Free article.
BACKGROUND: The caudal type homeobox 2 transcription factor (CDX2) is a specific and sensitive marker for intestinal carcinoma, but usually not expressed in breast cancer. In CDX2-positive metastatic cancer of occult primary, the origin is highly suspi …
BACKGROUND: The caudal type homeobox 2 transcription factor (CDX2) is a specific and sensitive marker for intestinal carcinoma, but u …
CDX2 inhibits epithelial-mesenchymal transition in colorectal cancer by modulation of Snail expression and beta-catenin stabilisation via transactivation of PTEN expression.
Yu J, Li S, Xu Z, Guo J, Li X, Wu Y, Zheng J, Sun X. Yu J, et al. Br J Cancer. 2021 Jan;124(1):270-280. doi: 10.1038/s41416-020-01148-1. Epub 2020 Nov 26. Br J Cancer. 2021. PMID: 33239678 Free PMC article.
BACKGROUND: Emerging evidence suggests the involvement of caudal-related homoeobox transcription factor 2 (CDX2) in tumorigenesis of various cancers. Although CDX2 functions in cancer invasion and metastasis, fewer studies focus on the role of CDX2 …
BACKGROUND: Emerging evidence suggests the involvement of caudal-related homoeobox transcription factor 2 (CDX2) in tumorigenesis of …
Expression of CDX2 in metastatic prostate cancer.
Guerrieri C, Jobbagy Z, Hudacko R. Guerrieri C, et al. Pathologica. 2019 Sep;111(3):105-107. doi: 10.32074/1591-951X-19-19. Pathologica. 2019. PMID: 31748757 Free PMC article.
The intestinal marker CDX2 has recently been found to stain a small percentage of primary prostate adenocarcinomas, but little is known of its expression in metastatic prostate cancers. We present a case of metastatic prostate adenocarcinoma that stained for CDX2 …
The intestinal marker CDX2 has recently been found to stain a small percentage of primary prostate adenocarcinomas, but little is kno …
CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer.
Mukohyama J, Agawa K, Yamashita K, Matsuda T, Shinoda M, Itano O, Kakeji Y. Mukohyama J, et al. Anticancer Res. 2023 Aug;43(8):3763-3767. doi: 10.21873/anticanres.16561. Anticancer Res. 2023. PMID: 37500172
BACKGROUND/AIM: Colorectal cancer (CRC) with reduced expression of the homeobox transcription factor CDX2, a master gene essential for the development and maintenance of the intestinal tract, is known as a poor prognosis subtype of CRC. ...The tissues from those pat …
BACKGROUND/AIM: Colorectal cancer (CRC) with reduced expression of the homeobox transcription factor CDX2, a master gene essen …
New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.
Yan LH, Wei WY, Xie YB, Xiao Q. Yan LH, et al. World J Gastroenterol. 2014 Apr 14;20(14):3960-6. doi: 10.3748/wjg.v20.i14.3960. World J Gastroenterol. 2014. PMID: 24744585 Free PMC article. Review.
Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. ...
Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recent …
LIN28B induces a differentiation program through CDX2 in colon cancer.
Suzuki K, Masuike Y, Mizuno R, Sachdeva UM, Chatterji P, Andres SF, Sun W, Klein-Szanto AJ, Besharati S, Remotti HE, Verzi MP, Rustgi AK. Suzuki K, et al. JCI Insight. 2021 May 10;6(9):e140382. doi: 10.1172/jci.insight.140382. JCI Insight. 2021. PMID: 33755595 Free PMC article.
A ChIP sequence for CDX2 identified alpha-methylacyl-CoA racemase (AMACR) as a potentially novel transcriptional target of CDX2 in the context of LIN28B overexpression. ...Overall, we demonstrated that LIN28B promotes CRC differentiation through the CDX2/AMAC …
A ChIP sequence for CDX2 identified alpha-methylacyl-CoA racemase (AMACR) as a potentially novel transcriptional target of CDX2 …
2,195 results