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Year Number of Results
1994 1
1995 1
1996 2
1997 1
1998 2
1999 3
2000 4
2001 2
2002 6
2003 2
2004 17
2005 7
2006 12
2007 18
2008 19
2009 12
2010 11
2011 18
2012 21
2013 26
2014 20
2015 23
2016 18
2017 23
2018 17
2019 18
2020 20
2021 27
2022 25
2023 22
2024 15

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368 results

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Page 1
Long-lasting cigarette smoking alterations in immune function occur in cannabis smokers, possibly rendering them vulnerable to smoking-related tumors in later life.
Lehrer S, Rheinstein PH. Lehrer S, et al. medRxiv [Preprint]. 2024 Apr 1:2024.04.01.24305156. doi: 10.1101/2024.04.01.24305156. medRxiv. 2024. PMID: 38633792 Free PMC article. Preprint.
In addition, smoking is linked to an increase in the level of the cytokine CEACAM6 in the bloodstream of smokers. CEACAM6 is increased in pancreatic adenocarcinoma, breast cancer, non small cell lung cancer, gastric cancer, colon cancer and other cancers and promote …
In addition, smoking is linked to an increase in the level of the cytokine CEACAM6 in the bloodstream of smokers. CEACAM6 is i …
Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
Michl J, White B, Monterisi S, Bodmer WF, Swietach P. Michl J, et al. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319055121. doi: 10.1073/pnas.2319055121. Epub 2024 Mar 19. Proc Natl Acad Sci U S A. 2024. PMID: 38502695 Free PMC article.
Finally, CEACAM6 levels were strongly increased in human colorectal cancers from stage II and III patients, compared to matched samples from adjacent normal tissues. Thus, CEACAM6 is a marker of acid-resistant clones in colorectal cancer and a potential motif for ta …
Finally, CEACAM6 levels were strongly increased in human colorectal cancers from stage II and III patients, compared to matched sampl …
Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models.
Nakazawa Y, Miyano M, Tsukamoto S, Kogai H, Yamamoto A, Iso K, Inoue S, Yamane Y, Yabe Y, Umihara H, Taguchi J, Akagi T, Yamaguchi A, Koga M, Toshimitsu K, Hirayama T, Mukai Y, Machinaga A. Nakazawa Y, et al. Nat Commun. 2024 Mar 11;15(1):2192. doi: 10.1038/s41467-024-46167-1. Nat Commun. 2024. PMID: 38467634 Free PMC article.
To improve PDAC therapy, we establish screening systems based on organoid and co-culture technologies and find a payload of antibody-drug conjugate (ADC), a bromodomain and extra-terminal (BET) protein degrader named EBET. We select CEACAM6/CD66c as an ADC target and devel …
To improve PDAC therapy, we establish screening systems based on organoid and co-culture technologies and find a payload of antibody-drug co …
Comparative analysis of prognosis and gene expression in prostate cancer patients with site-specific visceral metastases.
Zhang P, Chen T, Yang M. Zhang P, et al. Urol Oncol. 2024 May;42(5):160.e1-160.e10. doi: 10.1016/j.urolonc.2024.01.032. Epub 2024 Mar 2. Urol Oncol. 2024. PMID: 38433022 Free article.
Seven significant DEGs were identified from samples of liver and lung metastases (HERV-FRD, NUDT12, FAM63A, SCGB3A1, CEACAM6, LOC440416, SFTPB) and were associated with respiratory gaseous exchange, pulmonary surfactant metabolism, and fibronectin matrix formation in PPI n …
Seven significant DEGs were identified from samples of liver and lung metastases (HERV-FRD, NUDT12, FAM63A, SCGB3A1, CEACAM6, LOC4404 …
Pan-cancer analysis reveals a regulatory pattern of anoikis in human cancers.
Wang X, Yang C, Wang X, Duan P. Wang X, et al. Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):51-61. doi: 10.14715/cmb/2024.70.2.8. Cell Mol Biol (Noisy-le-grand). 2024. PMID: 38430038
In addition, our observations revealed a direct relationship between the expression of CEACAM5 and CEACAM6,the amplification of epithelial mesenchymal transition (EMT) phenomenon, and a decrease in survival outcomes.The potential therapeutic utility of anoikis-related gene …
In addition, our observations revealed a direct relationship between the expression of CEACAM5 and CEACAM6,the amplification of epith …
Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment.
Salvador-Martín S, Rubbini G, Vellosillo P, Zapata-Cobo P, Velasco M, Palomino LM, Clemente S, Segarra O, Moreno-Álvarez A, Fernández-Lorenzo A, Pérez-Moneo B, Montraveta M, Sánchez C, Tolín M, Loverdos I, Fobelo MJ, Navas-López VM, Magallares L, García-Romero R, Torres-Peral R, Rodríguez A, Bossacoma F, Merino-Bohórquez V, Salcedo E, Álvarez R, Dopazo A, Sanjurjo-Sáez M, López-Fernández LA. Salvador-Martín S, et al. Biomed Pharmacother. 2024 Apr;173:116299. doi: 10.1016/j.biopha.2024.116299. Epub 2024 Feb 23. Biomed Pharmacother. 2024. PMID: 38401525 Free article.
Gene Set Enrichment Analysis (GSEA) revealed notable enrichment in transcriptional misregulation in cancer (FDR = 0.016). Notably, 13 genes (CEACAM8, CEACAM6, CILP2, COL17A1, OLFM4, INHBA, LCN2, LTF, MMP8, DEFA4, PRTN3, AZU1, and ELANE) were selected for validation, and a …
Gene Set Enrichment Analysis (GSEA) revealed notable enrichment in transcriptional misregulation in cancer (FDR = 0.016). Notably, 13 genes …
ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer.
Vilasi SM, Nguyen J, Wang CJ, Miao L, Daily K, Eid M, Song JS, Jiang H, Ylaya K, Busam KJ, Gaiser MR, Hewitt SM, Brownell I. Vilasi SM, et al. Cancers (Basel). 2024 Feb 15;16(4):788. doi: 10.3390/cancers16040788. Cancers (Basel). 2024. PMID: 38398178 Free PMC article.
All three MCC markers were sensitive and specific, with CK20 and ATOH1 staining 43/43 (100%) MCC and 0/59 (0%) SCLC cases and TFAP2B staining 40/43 (93%) MCC and 0/59 (0%) SCLC cases. TTF-1 stained 47/59 (80%) SCLC and 1/43 (2%) MCC cases. CEACAM6 stained 49/59 (83%) SCLC …
All three MCC markers were sensitive and specific, with CK20 and ATOH1 staining 43/43 (100%) MCC and 0/59 (0%) SCLC cases and TFAP2B stainin …
L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy.
Jardim-Perassi BV, Irrera P, Oluwatola OE, Abrahams D, Estrella VC, Ordway B, Byrne SR, Ojeda AA, Whelan CJ, Kim J, Beatty MS, Damgaci-Erturk S, Longo DL, Gaspar KJ, Siegers GM, Centeno BA, Lau JYC, Pilon-Thomas SA, Ibrahim-Hashim A, Gillies RJ. Jardim-Perassi BV, et al. Biomedicines. 2024 Feb 19;12(2):461. doi: 10.3390/biomedicines12020461. Biomedicines. 2024. PMID: 38398062 Free PMC article.
L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor acidity, has been well tolerated in phase I/IIa trials. L-DOS47 binds to CEACAM6, a cell-surface protein that is highly expressed in gastrointestinal cancers, allowing urease to cleave endogenous u …
L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor acidity, has been well tolerated in phase I/IIa trials. L-DOS47 …
Smoking changes adaptive immunity with persistent effects.
Saint-André V, Charbit B, Biton A, Rouilly V, Possémé C, Bertrand A, Rotival M, Bergstedt J, Patin E, Albert ML, Quintana-Murci L, Duffy D; Milieu Intérieur Consortium. Saint-André V, et al. Nature. 2024 Feb;626(8000):827-835. doi: 10.1038/s41586-023-06968-8. Epub 2024 Feb 14. Nature. 2024. PMID: 38355791 Free PMC article.
Notably, its effect on innate responses is quickly lost after smoking cessation and is specifically associated with plasma levels of CEACAM6, whereas its effect on adaptive responses persists long after individuals quit smoking and is associated with epigenetic memory. ...
Notably, its effect on innate responses is quickly lost after smoking cessation and is specifically associated with plasma levels of CEAC …
Diagnostic value of cerebrospinal fluid human epididymis protein 4 for leptomeningeal metastasis in lung adenocarcinoma.
Li X, Chen K, Li J, Tang X, Ruan H, Guan M. Li X, et al. Front Immunol. 2024 Jan 18;15:1339914. doi: 10.3389/fimmu.2024.1339914. eCollection 2024. Front Immunol. 2024. PMID: 38304432 Free PMC article.
The HE4 or CEACAM6 level in CSF was higher than that in serum of LM patient. ...The better discriminative power for LM was achieved when HE4 was combined with CEACAM6. In addition, the CSF HE4 and CEACAM6 level showed little or no difference between Wiot-LM/B …
The HE4 or CEACAM6 level in CSF was higher than that in serum of LM patient. ...The better discriminative power for LM was achieved w …
368 results