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Ceramide synthase 3 affects invasion and metastasis of hepatocellular carcinoma via the SMAD6 gene.
Cai J, Liu Y, Li Q, Wen Z, Li Y, Chen X. Cai J, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 May 28;47(5):588-599. doi: 10.11817/j.issn.1672-7347.2022.210477. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022. PMID: 35753729 Free PMC article. Chinese, English.
Functionally, CerS3 participates in the proliferation, invasion and metastasis of liver cancer cells via activating SMAD6 gene. ...Functionally, CerS3 participates in the proliferation, invasion and metastasis of liver cancer cells via activating SMAD6 …
Functionally, CerS3 participates in the proliferation, invasion and metastasis of liver cancer cells via activating SMAD6 gene …
Mammalian ceramide synthases.
Levy M, Futerman AH. Levy M, et al. IUBMB Life. 2010 May;62(5):347-56. doi: 10.1002/iub.319. IUBMB Life. 2010. PMID: 20222015 Free PMC article. Review.
Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases.. …
Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as …
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Qian H, Deng J, Lu C, Hou G, Zhang H, Zhang M, Fang Z, Lv XD. Qian H, et al. Exp Lung Res. 2021 Feb;47(1):37-53. doi: 10.1080/01902148.2020.1844345. Epub 2020 Nov 12. Exp Lung Res. 2021. PMID: 33183094
As key regulators of sphingolipid metabolism, CerSs highlight their unique characteristics and have emerging roles in regulating programmed cell death, cancer and many other aspects of biology. However, the role of CerSs in lung cancer has not been fully elucidated. …
As key regulators of sphingolipid metabolism, CerSs highlight their unique characteristics and have emerging roles in regulating programmed …
S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression.
Wang X, Qiu Z, Dong W, Yang Z, Wang J, Xu H, Sun T, Huang Z, Jin J. Wang X, et al. Cell Death Dis. 2022 Sep 6;13(9):768. doi: 10.1038/s41419-022-05210-z. Cell Death Dis. 2022. PMID: 36068200 Free PMC article.
Further study also revealed that S1PR1 promotes angiogenesis by decreasing ceramide levels via CerS3 downregulation. Interestingly, we demonstrated that S1PR1 downregulates CerS3 by inducing CerS6 translocation into the nucleus to inhibit CerS3 at the transcr …
Further study also revealed that S1PR1 promotes angiogenesis by decreasing ceramide levels via CerS3 downregulation. Interestingly, w …
Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes.
Youssefian L, Vahidnezhad H, Saeidian AH, Sotoudeh S, Mahmoudi H, Daneshpazhooh M, Aghazadeh N, Adams R, Ghanadan A, Zeinali S, Fortina P, Uitto J. Youssefian L, et al. Eur J Hum Genet. 2017 Nov;25(11):1282-1285. doi: 10.1038/ejhg.2017.137. Epub 2017 Sep 6. Eur J Hum Genet. 2017. PMID: 28875980 Free PMC article.
Among these patients we identified six distinct, previously unreported mutations in CERS3 in six Iranian families. These mutations in each family co-segregated with the ichthyosis phenotype. The patients demonstrated collodion membrane at birth, acrogeria, generalized scal …
Among these patients we identified six distinct, previously unreported mutations in CERS3 in six Iranian families. These mutations in …
Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors.
Rabionet M, Bayerle A, Jennemann R, Heid H, Fuchser J, Marsching C, Porubsky S, Bolenz C, Guillou F, Gröne HJ, Gorgas K, Sandhoff R. Rabionet M, et al. Hum Mol Genet. 2015 Sep 1;24(17):4792-808. doi: 10.1093/hmg/ddv204. Epub 2015 Jun 4. Hum Mol Genet. 2015. PMID: 26045466
This pattern correlates with and depends on ceramide synthase 3 (CerS3) localization in both, pachytene spermatocytes until completion of meiosis and elongating spermatids. (2) Blocking the pathways to germ cell-specific ceramides (CerS3-KO) and further to glycosphi …
This pattern correlates with and depends on ceramide synthase 3 (CerS3) localization in both, pachytene spermatocytes until completio …
Very long chain sphingolipids: tissue expression, function and synthesis.
Sandhoff R. Sandhoff R. FEBS Lett. 2010 May 3;584(9):1907-13. doi: 10.1016/j.febslet.2009.12.032. Epub 2009 Dec 24. FEBS Lett. 2010. PMID: 20035755 Free article. Review.
However, epidermal keratinocytes and male germ cells largely express sphingolipids with very long chain-acyl moieties (C26-C36) during their differentiation and maturation. This expression seems to depend on CerS3, one of six ceramide synthases. However, the complex biosyn …
However, epidermal keratinocytes and male germ cells largely express sphingolipids with very long chain-acyl moieties (C26-C36) during their …
Loss of ceramide synthase 3 causes lethal skin barrier disruption.
Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Gröne HJ, Sandhoff R. Jennemann R, et al. Hum Mol Genet. 2012 Feb 1;21(3):586-608. doi: 10.1093/hmg/ddr494. Epub 2011 Oct 28. Hum Mol Genet. 2012. PMID: 22038835
Epidermis-unique ceramides with ultra-long-chain acyl moities (ULC-Cers) are key components of extracellular lipid lamellae (ELL) and are bound to CE proteins, thereby contributing to the cornified lipid envelope (CLE). Here, we identified human and mouse ceramide synthase 3 ( …
Epidermis-unique ceramides with ultra-long-chain acyl moities (ULC-Cers) are key components of extracellular lipid lamellae (ELL) and are bo …
Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis.
Simpson JK, Martinez-Queipo M, Onoufriadis A, Tso S, Glass E, Liu L, Higashino T, Scott W, Tierney C, Simpson MA, Desomchoke R, Youssefian L, SaeIdian AH, Vahidnezhad H, Bisquera A, Ravenscroft J, Moss C, O'Toole EA, Burrows N, Leech S, Jones EA, Lim D, Ilchyshyn A, Goldstraw N, Cork MJ, Darne S, Uitto J, Martinez AE, Mellerio JE, McGrath JA. Simpson JK, et al. Br J Dermatol. 2020 Mar;182(3):729-737. doi: 10.1111/bjd.18211. Epub 2019 Aug 26. Br J Dermatol. 2020. PMID: 31168818
Pathogenic biallelic mutations were found in 83% of cases, with the candidate gene spread as follows: TGM1 29%, NIPAL4 12%, ABCA12 12%, ALOX12B 9%, ALOXE3 7%, SLC27A4 5%, CERS3 3%, CYP4F22 3%, PNPLA1 2%, SDR9C7 1%. Clinically, a new sign, an anteriorly overfolded ear at bi …
Pathogenic biallelic mutations were found in 83% of cases, with the candidate gene spread as follows: TGM1 29%, NIPAL4 12%, ABCA12 12%, ALOX …
Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes.
Rabionet M, Bernard P, Pichery M, Marsching C, Bayerle A, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Asadi A, Ebel P, Hoekstra M, Dumas S, Ntambi JM, Jacobsson A, Willecke K, Medin JA, Jonca N, Sandhoff R. Rabionet M, et al. Lipids. 2022 May;57(3):183-195. doi: 10.1002/lipd.12342. Epub 2022 Mar 23. Lipids. 2022. PMID: 35318678
In search of potential enzymes responsible for 1-OAC synthesis in vivo, we analyzed mutant mice with deficiencies of ceramide synthases (Cers2, Cers3, or Cers4), diacylglycerol acyltransferases (Dgat1 or Dgat2), elongase of very long fatty acids 3 (Elovl3), lecithin choles …
In search of potential enzymes responsible for 1-OAC synthesis in vivo, we analyzed mutant mice with deficiencies of ceramide synthases (Cer …
15 results