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Year Number of Results
1991 1
1996 2
1997 1
1998 1
1999 3
2001 2
2002 1
2003 5
2004 6
2005 11
2006 11
2007 14
2008 17
2009 28
2010 30
2011 17
2012 33
2013 31
2014 36
2015 45
2016 44
2017 40
2018 38
2019 51
2020 50
2021 55
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2023 58
2024 17

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611 results

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Page 1
Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro.
Liang JH, Yi XL, Gong JM, Du Z. Liang JH, et al. Toxicol In Vitro. 2024 Apr 24;98:105833. doi: 10.1016/j.tiv.2024.105833. Online ahead of print. Toxicol In Vitro. 2024. PMID: 38670244
The present study aimed to evaluate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat, benzbromarone, lesinurad and probenecid) on the activity of the crucial phase I drug-metabolizing enzymes, carboxylesterases (CESs). 2-(2-benzoyl-3-methoxyphenyl) b …
The present study aimed to evaluate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat, benzbromarone, lesinurad …
Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics.
Singh DK, Ahire D, Davydov DR, Prasad B. Singh DK, et al. Drug Metab Dispos. 2024 Apr 19:DMD-AR-2023-001477. doi: 10.1124/dmd.124.001477. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38641346 Free article.
UGT2B7, MGST1, MGST2, MGST3, CES2, and MRP2 were expressed in all three tissues, whereas, as expected CYP3A4, CYP3A5, CYP2C9, CYP4F2, UGT1A1, UGT2B17, CES1, FMO5, MRP3, and P-gp were present in the liver and intestine. The top three DMET proteins in individual tissues were …
UGT2B7, MGST1, MGST2, MGST3, CES2, and MRP2 were expressed in all three tissues, whereas, as expected CYP3A4, CYP3A5, CYP2C9, CYP4F2, UGT1A1 …
The Effect of ABCB1 and CES1 Polymorphisms on Plasma Levels of Dabigatran and Risk of Hemorrhagic Complications in Ischemic Stroke Patients.
Anna O, Petr J, Hana M, Tereza Š, Petra K, Silvia K, Vlastimil Š, Hana H, Martin Š, Ivana Š, Jaroslava PS, Kateřina B, Jan M, Václav M, Aleš T. Anna O, et al. Am J Ther. 2024 Mar 20. doi: 10.1097/MJT.0000000000001710. Online ahead of print. Am J Ther. 2024. PMID: 38525959
STUDY QUESTION: We conducted a study to assess how polymorphisms in the CES1 (rs2244613) and ABCB1 (rs4148738) genes affect the through plasma level (cmin) of dabigatran and its correlation to clinical outcomes. ...The ABCB1 variant genotype was present in 67.8% of patient …
STUDY QUESTION: We conducted a study to assess how polymorphisms in the CES1 (rs2244613) and ABCB1 (rs4148738) genes affect the throu …
The Metabolism of the New Benzodiazepine Remimazolam.
Schmalix W, Petersen KU, Pesic M, Stöhr T. Schmalix W, et al. Curr Drug Metab. 2024 Mar 21. doi: 10.2174/0113892002301026240318060307. Online ahead of print. Curr Drug Metab. 2024. PMID: 38523539
Using bacterial or eukaryotic over-expression systems, carboxylesterase 1 (CES1) was identified as the iso-enzyme predominantly involved in RMZ metabolism, with no role for carboxylesterase 2. Using a variety of inhibitors of other esterases, the contribution to eliminatio …
Using bacterial or eukaryotic over-expression systems, carboxylesterase 1 (CES1) was identified as the iso-enzyme predominantly invol …
Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology.
Nagaoka M, Sakai Y, Nakajima M, Fukami T. Nagaoka M, et al. Biochem Pharmacol. 2024 May;223:116128. doi: 10.1016/j.bcp.2024.116128. Epub 2024 Mar 15. Biochem Pharmacol. 2024. PMID: 38492781 Review.
Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC), which are expressed primarily in the liver and/or gastrointestinal tract, hydrolyze drugs containing ester and amide bonds in their chemical structure. ...Recently,in vitroandin vivostudies have shown …
Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC), which are expressed primarily in the liver and/or gastrointe …
High lymphocyte signature genes expression in parathyroid endocrine cells and its downregulation linked to tumorigenesis.
Geng C, Liu J, Guo B, Liu K, Gong P, Wang B, Wan Q, Sun L, Zhao J, Song Y. Geng C, et al. EBioMedicine. 2024 Apr;102:105053. doi: 10.1016/j.ebiom.2024.105053. Epub 2024 Mar 11. EBioMedicine. 2024. PMID: 38471398 Free PMC article.
Finally, along the developmental trajectory, we discovered the loss of POMC, ART5, and CES1 expression as the earliest signature of parathyroid hyperplasia. ...
Finally, along the developmental trajectory, we discovered the loss of POMC, ART5, and CES1 expression as the earliest signature of p …
Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?
Cross B, Turner RM, Zhang JE, Pirmohamed M. Cross B, et al. Pharmacogenomics J. 2024 Mar 5;24(2):7. doi: 10.1038/s41397-024-00329-y. Pharmacogenomics J. 2024. PMID: 38443337 Free PMC article. Review.
Validated variants in VKORC1, CYP2C9 and CYP4F2 constitute biomarkers for differential warfarin response and genotype-informed warfarin dosing has been shown to reduce adverse clinical events. Polymorphisms in CES1 appear relevant to dabigatran exposure but the genetic stu …
Validated variants in VKORC1, CYP2C9 and CYP4F2 constitute biomarkers for differential warfarin response and genotype-informed warfarin dosi …
Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects.
Luo X, Zhang Z, Mu R, Hu G, Liu L, Liu X. Luo X, et al. Pharmaceutics. 2024 Feb 5;16(2):234. doi: 10.3390/pharmaceutics16020234. Pharmaceutics. 2024. PMID: 38399287 Free PMC article.
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. ...The sensitivity analysis showed that the decreased plasma exposure of active metabolites due to the decreased CES1 was partly …
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metaboli …
Integrated study reveals mechanism of Tripterygium Wilfordii against cholangiocarcinoma based on bioinformatics approaches and molecular dynamics simulation.
Zhao Y, Guo J. Zhao Y, et al. Comput Biol Chem. 2024 Apr;109:108030. doi: 10.1016/j.compbiolchem.2024.108030. Epub 2024 Feb 14. Comput Biol Chem. 2024. PMID: 38387122
RESULTS: A total of 67 ingredients in TW were collected, and 495 genes were obtained as genes of CHOL. 55 common TW-CHOL targets were identified. 171 biological process terms and 100 KEGG pathways were enriched. 12 genes were regarded as core genes through PPI analysis, such as C …
RESULTS: A total of 67 ingredients in TW were collected, and 495 genes were obtained as genes of CHOL. 55 common TW-CHOL targets were identi …
611 results