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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 1
2006 1
2007 1
2008 1
2009 1
2010 8
2011 19
2012 26
2013 31
2014 45
2015 41
2016 40
2017 51
2018 70
2019 77
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644 results

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Page 1
Tbl1 promotes Wnt/β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse ESCs.
Yu Y, Liu L, Cao J, Huang R, Duan Q, Ye SD. Yu Y, et al. J Cell Sci. 2024 Apr 19:jcs.261241. doi: 10.1242/jcs.261241. Online ahead of print. J Cell Sci. 2024. PMID: 38639717
Activation of the Wnt/beta-catenin signaling pathway by CHIR99021, a specific inhibitor of GSK3beta, induces Tcf7l1 protein degradation, which facilitates the maintenance of an undifferentiated state in mouse embryonic stem cells (mESCs). ...Mechanistically, Tbl1 transloca …
Activation of the Wnt/beta-catenin signaling pathway by CHIR99021, a specific inhibitor of GSK3beta, induces Tcf7l1 protein degradati …
Conversion of Astrocyte Cell Lines to Oligodendrocyte Progenitor Cells Using Small Molecules and Transplantation to Animal Model of Multiple Sclerosis.
Sharifi-Kelishadi M, Zare L, Fathollahi Y, Javan M. Sharifi-Kelishadi M, et al. J Mol Neurosci. 2024 Apr 9;74(2):40. doi: 10.1007/s12031-024-02206-6. J Mol Neurosci. 2024. PMID: 38594388
Astrocytes were transferred to an OPC medium and exposed for five days to a small molecule cocktail containing CHIR99021, Forskolin, Repsox, LDN, VPA and Thiazovivin before being preserved in the OPC medium for an additional 10 days. ...
Astrocytes were transferred to an OPC medium and exposed for five days to a small molecule cocktail containing CHIR99021, Forskolin, …
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway.
Yamada S, Hashita T, Yanagida S, Sato H, Yasuhiko Y, Okabe K, Noda T, Nishida M, Matsunaga T, Kanda Y. Yamada S, et al. Fluids Barriers CNS. 2024 Apr 8;21(1):32. doi: 10.1186/s12987-024-00533-9. Fluids Barriers CNS. 2024. PMID: 38584257 Free PMC article.
Furthermore, RNA-seq analysis revealed that SARS-CoV-2 dysregulated the canonical Wnt signaling pathway in iPSC-BMELCs. Modulation of the Wnt signaling by CHIR99021 partially inhibited the infection and the subsequent inflammatory responses. ...
Furthermore, RNA-seq analysis revealed that SARS-CoV-2 dysregulated the canonical Wnt signaling pathway in iPSC-BMELCs. Modulation of the Wn …
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway.
Kurita H, Ueda M, Kimura M, Okuda A, Ohuchi K, Hozumi I, Inden M. Kurita H, et al. Biol Pharm Bull. 2024;47(4):796-800. doi: 10.1248/bpb.b24-00019. Biol Pharm Bull. 2024. PMID: 38583951 Free article.
Neurite outgrowth inhibited by low zinc was restored by treatment with the GSK3beta inhibitor CHIR99021. These results suggested that low zinc causes neurite outgrowth inhibition via phosphorylation of CRMP2 by GSK3beta. ...
Neurite outgrowth inhibited by low zinc was restored by treatment with the GSK3beta inhibitor CHIR99021. These results suggested that …
Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis.
Fleischhacker V, Milosic F, Bricelj M, Kührer K, Wahl-Figlash K, Heimel P, Diendorfer A, Nardini E, Fischer I, Stangl H, Pietschmann P, Hackl M, Foisner R, Grillari J, Hengstschläger M, Osmanagic-Myers S. Fleischhacker V, et al. Aging Cell. 2024 Apr 5:e14139. doi: 10.1111/acel.14139. Online ahead of print. Aging Cell. 2024. PMID: 38578073 Free article.
Moreover, we show that inhibition of microRNA-31-5p as well as selective Wnt-activator CHIR99021 boosts the osteogenic potential of BMSCs through de-repression and activation of the Wnt-signaling, respectively. ...
Moreover, we show that inhibition of microRNA-31-5p as well as selective Wnt-activator CHIR99021 boosts the osteogenic potential of B …
Assessment of the feasibility of human amniotic membrane stem cell-derived cardiomyocytes in vitro.
Shih HM, Chen YC, Yeh YT, Peng FS, Wu SC. Shih HM, et al. Heliyon. 2024 Mar 19;10(7):e28398. doi: 10.1016/j.heliyon.2024.e28398. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38560255 Free PMC article.
The expression levels of MLC2v, Nkx2.5, and MyoD were analyzed using qPCR after applying various protocols for chemical induction, including BMP4, ActivinA, 5-azacytidine, CHIR99021, and IWP2 on hAMSCs. The group treated with 5 ng/ml BMP4, 10 ng/ml Activin A, 10 muM 5-azac …
The expression levels of MLC2v, Nkx2.5, and MyoD were analyzed using qPCR after applying various protocols for chemical induction, including …
Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks.
Kriedemann N, Triebert W, Teske J, Mertens M, Franke A, Ullmann K, Manstein F, Drakhlis L, Haase A, Halloin C, Martin U, Zweigerdt R. Kriedemann N, et al. Nat Protoc. 2024 Mar 28. doi: 10.1038/s41596-024-00976-2. Online ahead of print. Nat Protoc. 2024. PMID: 38548938 Review.
After 48 h at checkpoint (CP) 0, chemically defined cardiac differentiation is induced by WNT-pathway modulation through use of the glycogen-synthase kinase-3 inhibitor CHIR99021 (WNT agonist), which is replaced 24 h later by the chemical WNT-pathway inhibitor IWP-2. ...
After 48 h at checkpoint (CP) 0, chemically defined cardiac differentiation is induced by WNT-pathway modulation through use of the glycogen …
Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications.
Durczak PM, Fair KL, Jinks N, Cuevas Ocaña S, Sainz Zuñiga CB, Hannan NRF. Durczak PM, et al. J Vis Exp. 2024 Mar 8;(205). doi: 10.3791/61199. J Vis Exp. 2024. PMID: 38526083
., Matrigel or other compatible ECM) supplemented with SB202190, A83-01, Gastrin, Noggin, EGF, R-spondin-1 and CHIR99021. Organoids undergo passaging every 7 days, where they are mechanically disrupted before transfer to fresh extracellular matrix and allowed to expand. .. …
., Matrigel or other compatible ECM) supplemented with SB202190, A83-01, Gastrin, Noggin, EGF, R-spondin-1 and CHIR99021. Organoids u …
Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Mardones MD, Rostam KD, Nickerson MC, Gupta K. Mardones MD, et al. Exp Neurol. 2024 Mar 22;376:114767. doi: 10.1016/j.expneurol.2024.114767. Online ahead of print. Exp Neurol. 2024. PMID: 38522659
Wnt activator Chir99021 was administered daily, beginning 3 h after seizure induction, and continued up to 21-days. ...Activation of the canonical Wnt pathway with Chir99021 significantly reduced bilateral hippocampal seizure number and duration. ...
Wnt activator Chir99021 was administered daily, beginning 3 h after seizure induction, and continued up to 21-days. ...Activation of …
Mesenchymal stem cells derived from CHIR99021 and TGF-beta induction remained on the colicomentum and improved cardiac function of a rat model of acute myocardium infarction.
Zhang Y, Zhang Y, Hu A, Meng F, Cui P, Li T, Cui G. Zhang Y, et al. Exp Ther Med. 2024 Mar 4;27(5):182. doi: 10.3892/etm.2024.12470. eCollection 2024 May. Exp Ther Med. 2024. PMID: 38515646 Free PMC article.
In the present study, the combined use of the GSK-3 inhibitor CHIR99021 and TGF-beta was used to obtain mesenchymal stem cell (MSC)-like cells from hiPSCs. ...Symptoms of hiPSC-MSC-induced immune reaction or tumour formation were not observed over the course of the experim …
In the present study, the combined use of the GSK-3 inhibitor CHIR99021 and TGF-beta was used to obtain mesenchymal stem cell (MSC)-l …
644 results