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CHRNB2 represses pancreatic cancer migration and invasion via inhibiting beta-catenin pathway.
Qin C, Li T, Wang Y, Zhao B, Li Z, Li T, Yang X, Zhao Y, Wang W. Qin C, et al. Cancer Cell Int. 2022 Nov 7;22(1):340. doi: 10.1186/s12935-022-02768-8. Cancer Cell Int. 2022. PMID: 36344976 Free PMC article.
Next, knockdown of CHRNB2 expression could acetylcholine (ACh)-independently increase the migration and invasion of pancreatic cancer cells, while CHRNB2 overexpression ACh-independently decrease the migration and invasion of pancreatic cancer cells. . …
Next, knockdown of CHRNB2 expression could acetylcholine (ACh)-independently increase the migration and invasion of pancreatic can …
Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells.
Kanda M, Shimizu D, Nakamura S, Sawaki K, Umeda S, Miwa T, Tanaka H, Inokawa Y, Hattori N, Hayashi M, Tanaka C, Nakayama G, Iguchi Y, Katsuno M, Kodera Y. Kanda M, et al. Oncogene. 2021 Sep;40(36):5495-5504. doi: 10.1038/s41388-021-01945-9. Epub 2021 Jul 30. Oncogene. 2021. PMID: 34331011
We determined the effects of Chrnb2 deficiency on mice and the clinical significance of CHRNB2 expression in gastric cancer clinical specimens. Knockdown of CHRNB2 attenuated gastric cancer cell proliferation, whereas forced overexpression of …
We determined the effects of Chrnb2 deficiency on mice and the clinical significance of CHRNB2 expression in gastric cancer …
Rare coding variants in CHRNB2 reduce the likelihood of smoking.
Rajagopal VM, Watanabe K, Mbatchou J, Ayer A, Quon P, Sharma D, Kessler MD, Praveen K, Gelfman S, Parikshak N, Otto JM, Bao S, Chim SM, Pavlopoulos E, Avbersek A, Kapoor M, Chen E, Jones MB, Leblanc M, Emberson J, Collins R, Torres J, Morales PK, Tapia-Conyer R, Alegre J, Berumen J; GHS-REGN DiscovEHR collaboration; Regeneron Genetics Center; Shuldiner AR, Balasubramanian S, Abecasis GR, Kang HM, Marchini J, Stahl EA, Jorgenson E, Sanchez R, Liedtke W, Anderson M, Cantor M, Lederer D, Baras A, Coppola G. Rajagopal VM, et al. Nat Genet. 2023 Jul;55(7):1138-1148. doi: 10.1038/s41588-023-01417-8. Epub 2023 Jun 12. Nat Genet. 2023. PMID: 37308787 Free PMC article.
We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective association in CHRNB2, encoding the beta2 subunit of the alpha4beta2 nicotine acetylcholine receptor. ...Our genetic discovery will inspire future dr …
We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective association in …
BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer.
Yasumoto A, Fujimori H, Mochizuki M, Shibuya-Takahashi R, Nakamura-Shima M, Shindo N, Yamaguchi K, Fukushi D, Wakui Y, Sugai T, Iwai W, Abue M, Sato I, Satoh K, Katayose Y, Yasuda J, Shibata C, Tamai K. Yasumoto A, et al. Biochem Biophys Res Commun. 2023 May 7;655:59-67. doi: 10.1016/j.bbrc.2023.03.025. Epub 2023 Mar 11. Biochem Biophys Res Commun. 2023. PMID: 36933308
Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still limited. ...BEX2 was found to upregulate CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) expression, a cancer stemness-r …
Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still l …
Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.
Gabriel AAG, Atkins JR, Penha RCC, Smith-Byrne K, Gaborieau V, Voegele C, Abedi-Ardekani B, Milojevic M, Olaso R, Meyer V, Boland A, Deleuze JF, Zaridze D, Mukeriya A, Swiatkowska B, Janout V, Schejbalová M, Mates D, Stojšić J, Ognjanovic M; ILCCO consortium; Witte JS, Rashkin SR, Kachuri L, Hung RJ, Kar S, Brennan P, Sertier AS, Ferrari A, Viari A, Johansson M, Amos CI, Foll M, McKay JD. Gabriel AAG, et al. J Natl Cancer Inst. 2022 Aug 8;114(8):1159-1166. doi: 10.1093/jnci/djac087. J Natl Cancer Inst. 2022. PMID: 35511172 Free PMC article.
BACKGROUND: Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking behaviors and DNA repair genes, but further work is required to identify susceptib …
BACKGROUND: Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS …
Recognition of DNA Methylation Molecular Features for Diagnosis and Prognosis in Gastric Cancer.
Liu D, Li L, Wang L, Wang C, Hu X, Jiang Q, Wang X, Xue G, Liu Y, Xue D. Liu D, et al. Front Genet. 2021 Oct 21;12:758926. doi: 10.3389/fgene.2021.758926. eCollection 2021. Front Genet. 2021. PMID: 34745226 Free PMC article.
Background: The management of gastric cancer (GC) still lacks tumor markers with high specificity and sensitivity. ...The prognostic risk score was an independent risk factor for the prognosis of GC, which was significantly correlated with N stage and tumor location, posit …
Background: The management of gastric cancer (GC) still lacks tumor markers with high specificity and sensitivity. ...The prognostic …
Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch.
Perkins KA, Lerman C, Mercincavage M, Fonte CA, Briski JL. Perkins KA, et al. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2608-12. doi: 10.1158/1055-9965.EPI-09-0166. Epub 2009 Sep 15. Cancer Epidemiol Biomarkers Prev. 2009. PMID: 19755656 Free PMC article.
We examined the association of a 3' untranslated region polymorphism (rs2072661) in the nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene with quitting success in response to nicotine versus placebo patch during a short-term test of patch effects. ...Abstinence …
We examined the association of a 3' untranslated region polymorphism (rs2072661) in the nicotinic acetylcholine receptor beta2 subunit (C …
Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2).
Lueders KK, Hu S, McHugh L, Myakishev MV, Sirota LA, Hamer DH. Lueders KK, et al. Nicotine Tob Res. 2002 Feb;4(1):115-25. doi: 10.1080/14622200110098419. Nicotine Tob Res. 2002. PMID: 11906688
The beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) is a logical candidate for influencing smoking behavior and nicotine dependence. We discovered six single nucleotide polymorphisms (SNPs) in the CHRNB2 gene by surveying 15.4 kb of genomic sequence in …
The beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) is a logical candidate for influencing smoking behavior and nicotin …
Analysis of key genes and signaling pathways involved in Helicobacter pylori-associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data.
Hu Y, He C, Liu JP, Li NS, Peng C, Yang-Ou YB, Yang XY, Lu NH, Zhu Y. Hu Y, et al. Helicobacter. 2018 Oct;23(5):e12530. doi: 10.1111/hel.12530. Epub 2018 Sep 2. Helicobacter. 2018. PMID: 30175534
BACKGROUND: Helicobacter pylori (H. pylori) infection is associated with the development of gastric cancer, although the mechanism is unclear. Herein, this study aimed to clarify the key genes and signaling pathways involved in H. pylori pathogenesis based on The Cancer …
BACKGROUND: Helicobacter pylori (H. pylori) infection is associated with the development of gastric cancer, although the mechanism is …
CHRNA5-A3-B4 and DRD2 Genes and Smoking Cessation Throughout Adulthood: A Longitudinal Study of Women.
Jones SK, Alberg AJ, Wallace K, Froeliger B, Carpenter MJ, Wolf BJ. Jones SK, et al. Nicotine Tob Res. 2023 May 22;25(6):1164-1173. doi: 10.1093/ntr/ntad026. Nicotine Tob Res. 2023. PMID: 36794842 Free PMC article.
The secondary aim tests whether genetic associations differ by smoking intensity. Associations between 10 SNPs in CHRNA5, CHRNA3, CHRNB2, CHRNB4, DRD2, and COMT and the probability of smoking cessation over time were evaluated in two longitudinal cohort studies of female n …
The secondary aim tests whether genetic associations differ by smoking intensity. Associations between 10 SNPs in CHRNA5, CHRNA3, CHRNB2 …
16 results