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69 results

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CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes.
Ding M, Xu HY, Zhou WY, Xia YF, Li BY, Shi YJ, Dou X, Yang QQ, Qian SW, Tang Y, Pan DN, Liu Y, Tang QQ. Ding M, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305717120. doi: 10.1073/pnas.2305717120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549287 Free PMC article.
CLCF1 levels decreased during thermogenic stimulation but were considerably increased in obesity. Adipocyte-specific CLCF1 transgenic (CLCF1-ATG) mice showed impaired energy expenditure and severe cold intolerance. ...
CLCF1 levels decreased during thermogenic stimulation but were considerably increased in obesity. Adipocyte-specific CLCF1 tra …
CRLF1 and CLCF1 in Development, Health and Disease.
Crisponi L, Buers I, Rutsch F. Crisponi L, et al. Int J Mol Sci. 2022 Jan 17;23(2):992. doi: 10.3390/ijms23020992. Int J Mol Sci. 2022. PMID: 35055176 Free PMC article. Review.
In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (IL)-6 cytokine CLCF1 (cardiotrophin-like cytokine factor 1) during development in physiological and pathological conditions with parti …
In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (I …
CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis.
Yuan Y, Li K, Ye X, Wen S, Zhang Y, Teng F, Zhou X, Deng Y, Yang X, Wang W, Lin J, Luo S, Zhang P, Shi G, Zhang H. Yuan Y, et al. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2310711121. doi: 10.1073/pnas.2310711121. Epub 2024 Jan 8. Proc Natl Acad Sci U S A. 2024. PMID: 38190531
Adenovirus-mediated overexpression of CLCF1 in BAT greatly impairs the thermogenic capacity of BAT and reduces the metabolic rate. ...Therefore, our results reveal the essential role of CLCF1 in regulating BAT thermogenesis and suggest that inhibiting CLCF1 s …
Adenovirus-mediated overexpression of CLCF1 in BAT greatly impairs the thermogenic capacity of BAT and reduces the metabolic rate. .. …
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression.
Song M, He J, Pan QZ, Yang J, Zhao J, Zhang YJ, Huang Y, Tang Y, Wang Q, He J, Gu J, Li Y, Chen S, Zeng J, Zhou ZQ, Yang C, Han Y, Chen H, Xiang T, Weng DS, Xia JC. Song M, et al. Hepatology. 2021 May;73(5):1717-1735. doi: 10.1002/hep.31792. Hepatology. 2021. PMID: 33682185
Inhibition of ERK1/2 or CLCF1/ciliary neurotrophic factor receptor signaling efficiently impaired CLCF1-mediated crosstalk among CAFs, tumor cells, and TANs both in vitro and in vivo. ...These results may support the CLCF1 cascade as a potential prognostic bi …
Inhibition of ERK1/2 or CLCF1/ciliary neurotrophic factor receptor signaling efficiently impaired CLCF1-mediated crosstalk amo …
CLCF1 is up-regulated in renal ischemia reperfusion injury and may associate with FOXO3.
Wang S, Hu X, Ma L, Zhang L, Tian Y. Wang S, et al. Ann Transl Med. 2022 Apr;10(7):399. doi: 10.21037/atm-21-4381. Ann Transl Med. 2022. PMID: 35530960 Free PMC article.
The levels of CLCF1 in IRI-treated kidney tissues and serum CLCF1 were upregulated compared to sham-operated mice. ...We observed that FOXO3 knockout induced an increase in serum CLCF1 levels in sham-operated mice. However, FOXO3 knockout failed to increase …
The levels of CLCF1 in IRI-treated kidney tissues and serum CLCF1 were upregulated compared to sham-operated mice. ...We obser …
CLCF1 Is a Novel Potential Immune-Related Target With Predictive Value for Prognosis and Immunotherapy Response in Glioma.
Jiang Y, Ji Q, Long X, Wang P, Tu Z, Zhang X, Zhu X, Huang K, Li J. Jiang Y, et al. Front Immunol. 2022 Feb 21;13:810832. doi: 10.3389/fimmu.2022.810832. eCollection 2022. Front Immunol. 2022. PMID: 35265072 Free PMC article.
The biological function analysis of CLCF1 in glioma showed that CLCF1 was closely associated with immune signatures, including immune-related pathways, immune cell infiltration, and immune checkpoints. Moreover, glioma patients with low CLCF1 expression showe …
The biological function analysis of CLCF1 in glioma showed that CLCF1 was closely associated with immune signatures, including …
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer.
Jones SA, Jenkins BJ. Jones SA, et al. Nat Rev Immunol. 2018 Dec;18(12):773-789. doi: 10.1038/s41577-018-0066-7. Nat Rev Immunol. 2018. PMID: 30254251 Review.
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) and cardiotrophin-like cytokine factor 1 (CLCF1). Membership of this cytokine family is def …
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrop …
CNTF induces Clcf1 in astrocytes to promote the differentiation of oligodendrocyte precursor cells.
Ji-Wei S, Zi-Ying L, Xiang T, Yang Y, Ju-Fen Z, Qing-Hua Z. Ji-Wei S, et al. Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 1):170-177. doi: 10.1016/j.bbrc.2022.10.013. Epub 2022 Oct 5. Biochem Biophys Res Commun. 2022. PMID: 36334441
We found that astrocytes, the most numerous groups in the CNS, exhibited a pathological role in the experimental autoimmune encephalomyelitis model, but after stimulation with CNTF-NSCs, a phenotypic switch occurred and induced the neurotrophic factor cardiotrophin-like cytokine …
We found that astrocytes, the most numerous groups in the CNS, exhibited a pathological role in the experimental autoimmune encephalomyeliti …
The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma.
Zhang Z, Tan X, Luo J, Yao H, Si Z, Tong JS. Zhang Z, et al. Cell Death Dis. 2020 Oct 23;11(10):902. doi: 10.1038/s41419-020-03123-3. Cell Death Dis. 2020. PMID: 33097691 Free PMC article.
Furthermore, we also show that miR-30a-5p directly targets CLCF1 and that sorafenib-mediated suppression of miR-30a-5p results in the upregulation of CLCF1 in HCC cells resistant to sorafenib. ...Therefore, this study indicates that targeting the miR-30a-5p/CLCF1 …
Furthermore, we also show that miR-30a-5p directly targets CLCF1 and that sorafenib-mediated suppression of miR-30a-5p results in the …
Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Muller glia proliferation in the light-damaged zebrafish retina.
Boyd P, Campbell LJ, Hyde DR. Boyd P, et al. Front Cell Dev Biol. 2023 Feb 10;11:1142586. doi: 10.3389/fcell.2023.1142586. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36846595 Free PMC article.
We found that CNTFR, Clcf1, and Crlf1a are required for Muller glia proliferation in the light-damaged retina. Furthermore, intravitreal injection of CLCF1/CRLF1 protected against rod photoreceptor cell death in the light-damaged retina and induced proliferation of …
We found that CNTFR, Clcf1, and Crlf1a are required for Muller glia proliferation in the light-damaged retina. Furthermore, intravitr …
69 results