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Comprehensive analysis and experimental validation reveal elevated CLCN4 is a promising biomarker in endometrial cancer.
Wang C, Li J, Liu W, Li S, Zhang Y, Jin Y, Cui J. Wang C, et al. Aging (Albany NY). 2023 Sep 5;15(17):8744-8769. doi: 10.18632/aging.204994. Epub 2023 Sep 5. Aging (Albany NY). 2023. PMID: 37671947 Free PMC article.
Then, the expression, prognosis, mutation, and functional enrichment of CLCN4 in UCEC were analyzed. Immunohistochemical experiment was used to verify the expression of CLCN4 in endometrial cancer tissues and normal tissues. ...Results revealed that high expr …
Then, the expression, prognosis, mutation, and functional enrichment of CLCN4 in UCEC were analyzed. Immunohistochemical experiment w …
Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases.
Ishiguro T, Avila H, Lin SY, Nakamura T, Yamamoto M, Boyd DD. Ishiguro T, et al. Br J Cancer. 2010 Feb 16;102(4):774-82. doi: 10.1038/sj.bjc.6605536. Epub 2010 Jan 19. Br J Cancer. 2010. PMID: 20087350 Free PMC article.
CLCN4-overexpressing RKO colon cancer cells were more resistant than controls to proton load-induced cytotoxicity, consistent with the H(+)-extruding function of this antiporter. ...CONCLUSIONS: CLCN4 is a novel driver of colon cancer progression....
CLCN4-overexpressing RKO colon cancer cells were more resistant than controls to proton load-induced cytotoxicity, consistent …
Synergy between dihydromyricetin intervention and irinotecan chemotherapy delays the progression of colon cancer in mouse models.
Zhu XH , Lang HD , Wang XL , Hui SC , Zhou M , Kang C , Yi L , Mi MT , Zhang Y . Zhu XH , et al. Food Funct. 2019 Apr 17;10(4):2040-2049. doi: 10.1039/c8fo01756e. Food Funct. 2019. PMID: 30907395
Colorectal cancer (CRC) is the third highest cause of cancer-related death and the main option for prolonged survival is chemotherapeutic intervention. ...In AOM/DSS cancer, tumors were sensitive to 100 mg kg-1 DMY chemotherapy under 100 mg kg-1 or 200 mg kg- …
Colorectal cancer (CRC) is the third highest cause of cancer-related death and the main option for prolonged survival is chemo …
A contravention of Ohno's law in mice.
Palmer S, Perry J, Ashworth A. Palmer S, et al. Nat Genet. 1995 Aug;10(4):472-6. doi: 10.1038/ng0895-472. Nat Genet. 1995. PMID: 7670497
The chloride channel gene, CLCN4, has been previously mapped to the X chromosome in humans. We isolated a cDNA clone for mouse Clcn4 and used this to map the gene in an interspecific backcross. ...
The chloride channel gene, CLCN4, has been previously mapped to the X chromosome in humans. We isolated a cDNA clone for mouse Clc …