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Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer.
Quadri HS, Aiken TJ, Allgaeuer M, Moravec R, Altekruse S, Hussain SP, Miettinen MM, Hewitt SM, Rudloff U. Quadri HS, et al. BMC Cancer. 2017 Jul 21;17(1):495. doi: 10.1186/s12885-017-3481-4. BMC Cancer. 2017. PMID: 28732488 Free PMC article.
We analyzed the expression levels of CNKSR1, a scaffold that influences MAPK/ERK pathway activity, in clinical pancreas cancer specimens and their impact on survival of patients with pancreatic cancer. METHODS: Immunohistochemical staining for CNKSR1 e …
We analyzed the expression levels of CNKSR1, a scaffold that influences MAPK/ERK pathway activity, in clinical pancreas cancer …
Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling.
Li D, Miermont AM, Sable R, Quadri HS, Mathews Griner LA, Martin SE, Odzorig T, De S, Ferrer M, Powers AS, Hewitt SM, Rudloff U. Li D, et al. Mol Cancer Res. 2023 Apr 1;21(4):316-331. doi: 10.1158/1541-7786.MCR-21-1036. Mol Cancer Res. 2023. PMID: 36790955 Free PMC article.
Here, we report the scaffolding protein connector enhancer of kinase suppressor of Ras 1 (CNKSR1) as mediator of resistance to MAPK (MEK) inhibition. MEK inhibition in CNKSR1high cancer cells induces translocation of CNKSR1 to the plasma membrane where the sc …
Here, we report the scaffolding protein connector enhancer of kinase suppressor of Ras 1 (CNKSR1) as mediator of resistance to MAPK ( …
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
Nishiyama K, Maekawa M, Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, Higashiyama S. Nishiyama K, et al. Life Sci Alliance. 2021 Jun 29;4(9):e202101095. doi: 10.26508/lsa.202101095. Print 2021 Sep. Life Sci Alliance. 2021. PMID: 34187934 Free PMC article.
Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) phosphorylation drives HER2-positive breast cancer cell proliferation. Enforced activation of phosphatases for those receptors could be a therapeutic option for HER2-positive breast cancers. ...Depletio …
Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) phosphorylation drives HER2-positive breast cancer cell proliferation …
Research into the characteristic molecules significantly affecting liver cancer immunotherapy.
Chen J, Jin H, Zhou H, Hei X, Liu K. Chen J, et al. Front Immunol. 2023 Feb 13;14:1029427. doi: 10.3389/fimmu.2023.1029427. eCollection 2023. Front Immunol. 2023. PMID: 36860864 Free PMC article.
BACKGROUND: The past decade has witnessed unprecedented scientific breakthroughs, including immunotherapy, which has great potential in clinical applications for liver cancer. METHODS: Public data were obtained from The Cancer Genome Atlas (TCGA) and International …
BACKGROUND: The past decade has witnessed unprecedented scientific breakthroughs, including immunotherapy, which has great potential in clin …
Identification of hub genes in bladder cancer based on weighted gene co-expression network analysis from TCGA database.
Wang L, Liu X, Yue M, Liu Z, Zhang Y, Ma Y, Luo J, Li W, Bai J, Yao H, Chen Y, Li X, Feng D, Song X. Wang L, et al. Cancer Rep (Hoboken). 2022 Sep;5(9):e1557. doi: 10.1002/cnr2.1557. Epub 2021 Sep 20. Cancer Rep (Hoboken). 2022. PMID: 34541834 Free PMC article.
To provide a new theoretical basis for the diagnosis and treatment of bladder cancer. METHODS AND RESULTS: Gene expression profiles and clinical data of MIBC were obtained by downloading from the Cancer Genome Atlas database. ...Finally, immunohistochemistry experim …
To provide a new theoretical basis for the diagnosis and treatment of bladder cancer. METHODS AND RESULTS: Gene expression profiles a …
Identification and validation of a novel signature for prediction the prognosis and immunotherapy benefit in bladder cancer.
Zhang Y, Lin Y, Lv D, Wu X, Li W, Wang X, Jiang D. Zhang Y, et al. PeerJ. 2022 Jan 25;10:e12843. doi: 10.7717/peerj.12843. eCollection 2022. PeerJ. 2022. PMID: 35127296 Free PMC article.
BACKGROUND: Bladder cancer (BC) is a common urinary tract system tumor with high recurrence rate and different populations show distinct response to immunotherapy. ...METHODS: The robust rank aggregation was conducted to integrate differently expressed genes (DEGs) in data …
BACKGROUND: Bladder cancer (BC) is a common urinary tract system tumor with high recurrence rate and different populations show disti …
Discriminating Potential Genetic Markers for Complete Response and Non-Complete Response Patients to Neoadjuvant Chemotherapy with Locally Advanced Rectal Cancer.
Bagaria J, Kim KO, Bagyinszky E, An SSA, Baek JH. Bagaria J, et al. Int J Environ Res Public Health. 2022 Mar 28;19(7):4008. doi: 10.3390/ijerph19074008. Int J Environ Res Public Health. 2022. PMID: 35409691 Free PMC article.
Background: Neoadjuvant chemoradiotherapy (nCRT) prior to surgery is considered standard therapy for locally advanced rectal cancer. Unfortunately, most patients with rectal cancer are resistant to radiotherapy. This might be a genetic cause. The role of certain rec …
Background: Neoadjuvant chemoradiotherapy (nCRT) prior to surgery is considered standard therapy for locally advanced rectal cancer. …
KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer.
Lee J, Seol MY, Jeong S, Kwon HJ, Lee CR, Ku CR, Kang SW, Jeong JJ, Shin DY, Nam KH, Lee EJ, Chung WY, Jo YS. Lee J, et al. J Mol Endocrinol. 2015 Apr;54(2):115-24. doi: 10.1530/JME-14-0270. Epub 2015 Jan 21. J Mol Endocrinol. 2015. PMID: 25608512
In addition, GSEA showed that high expression of KSR2 and connector enhancer of KSR1 (CNKSR1) also coordinately upregulated Notch signaling (KSR2: nominal P=0.0097, FDR q-value=0.154 and CNKSR1: nominal P<0.0001, FDR q-value=0.00554), and high CNKSR2 was associat …
In addition, GSEA showed that high expression of KSR2 and connector enhancer of KSR1 (CNKSR1) also coordinately upregulated Notch sig …
Identification of CNKSR1 as a biomarker for "cold" tumor microenvironment in lung adenocarcinoma: An integrative analysis based on a novel workflow.
Cai Q, Peng M. Cai Q, et al. Heliyon. 2024 Apr 4;10(8):e29126. doi: 10.1016/j.heliyon.2024.e29126. eCollection 2024 Apr 30. Heliyon. 2024. PMID: 38628722 Free PMC article.
The prognostic model built based on the CNKSR1 coexpression module also showed robust predictive performance. Additionally, IHC assessments have confirmed that the coexpression of CNKSR1 and PD-L1 is rare in LUAD samples. Notably, LUADs in the high-CNKSR1 gro …
The prognostic model built based on the CNKSR1 coexpression module also showed robust predictive performance. Additionally, IHC asses …
Gene biomarkers and classifiers for various subtypes of HTLV-1-caused ATLL cancer identified by a combination of differential gene co-expression and support vector machine algorithms.
Zarei Ghobadi M, Afsaneh E, Emamzadeh R. Zarei Ghobadi M, et al. Med Microbiol Immunol. 2023 Aug;212(4):263-270. doi: 10.1007/s00430-023-00767-8. Epub 2023 May 24. Med Microbiol Immunol. 2023. PMID: 37222763
Adult T-cell leukemia/lymphoma (ATLL) is pathogen-caused cancer that is progressed after the infection by human T-cell leukemia virus type 1. Four significant subtypes comprising acute, lymphoma, chronic, and smoldering have been identified for this cancer. However, …
Adult T-cell leukemia/lymphoma (ATLL) is pathogen-caused cancer that is progressed after the infection by human T-cell leukemia virus …
20 results