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COPB2: a transport protein with multifaceted roles in cancer development and progression.
Feng Y, Lei X, Zhang L, Wan H, Pan H, Wu J, Zou M, Zhu L, Mi Y. Feng Y, et al. Clin Transl Oncol. 2021 Nov;23(11):2195-2205. doi: 10.1007/s12094-021-02630-9. Epub 2021 Jun 8. Clin Transl Oncol. 2021. PMID: 34101128 Free PMC article. Review.
COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression …
COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, i …
Upregulation of COPB2 Promotes Prostate Cancer Proliferation and Invasion Through the MAPK/TGF-beta Signaling Pathway.
Feng Y, Sun C, Zhang L, Wan H, Zhou H, Chen Y, Zhu L, Xia G, Mi Y. Feng Y, et al. Front Oncol. 2022 May 6;12:865317. doi: 10.3389/fonc.2022.865317. eCollection 2022. Front Oncol. 2022. PMID: 35600351 Free PMC article.
There is increasing evidence that coatomer protein complex subunit beta 2 (COPB2) plays an important role in various cancer types. This study explored the role and the downstream mediators of COPB2 in prostate cancer (PCa). The expression of COPB2 …
There is increasing evidence that coatomer protein complex subunit beta 2 (COPB2) plays an important role in various cancer ty …
COPB2 is up-regulated in breast cancer and plays a vital role in the metastasis via N-cadherin and Vimentin.
Bhandari A, Zheng C, Sindan N, Sindan N, Quan R, Xia E, Thapa Y, Tamang D, Wang O, Ye X, Huang D. Bhandari A, et al. J Cell Mol Med. 2019 Aug;23(8):5235-5245. doi: 10.1111/jcmm.14398. Epub 2019 May 22. J Cell Mol Med. 2019. PMID: 31119859 Free PMC article.
With the sequencing technology, we found that coatomer protein complex subunit beta 2 (COPB2) gene is overexpressed in breast cancer tissues. However, the biological function of COPB2 in BC has yet to be determined. ...To best of our knowledge, our findings i …
With the sequencing technology, we found that coatomer protein complex subunit beta 2 (COPB2) gene is overexpressed in breast canc …
An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors.
Wu B, Wu Y, Guo X, Yue Y, Li Y, He X, Chen Y, Zhao W, Liu J, Wu X, Shen A, Zhang S. Wu B, et al. Biomed Res Int. 2021 Oct 12;2021:7405322. doi: 10.1155/2021/7405322. eCollection 2021. Biomed Res Int. 2021. PMID: 34676262 Free PMC article.
Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. ...It is interesting to note that COPB2 expressio …
Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer t …
Silencing of COPB2 inhibits the proliferation of gastric cancer cells and induces apoptosis via suppression of the RTK signaling pathway.
An C, Li H, Zhang X, Wang J, Qiang Y, Ye X, Li Q, Guan Q, Zhou Y. An C, et al. Int J Oncol. 2019 Apr;54(4):1195-1208. doi: 10.3892/ijo.2019.4717. Epub 2019 Feb 18. Int J Oncol. 2019. PMID: 30968146 Free PMC article.
Therefore, the present study aimed to determine the significance and function of COPB2 in gastric cancer. COPB2 expression in gastric cancer cell lines was measured using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. …
Therefore, the present study aimed to determine the significance and function of COPB2 in gastric cancer. COPB2 express …
MiR-216a-3p regulates the proliferation, apoptosis, migration, and invasion of lung cancer cells via targeting COPB2.
Wang X, Shi J, Niu Z, Wang J, Zhang W. Wang X, et al. Biosci Biotechnol Biochem. 2020 Oct;84(10):2014-2027. doi: 10.1080/09168451.2020.1783197. Epub 2020 Jul 3. Biosci Biotechnol Biochem. 2020. PMID: 32619135
MiR-216a-3p was low-expressed and COPB2 was high-expressed in lung cancer tissues and cells. MiR-216a-3p targeted COPB2 and regulated its expression. ...Effect of miR-216a-3p on lung cancer was reversed by COPB2. MiR-216a-3p regulated proliferat …
MiR-216a-3p was low-expressed and COPB2 was high-expressed in lung cancer tissues and cells. MiR-216a-3p targeted COPB2 …
SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer.
Liu A, Zhang S, Li W, Xu B, Lei R, Zhu S. Liu A, et al. Aging (Albany NY). 2020 Jan 11;12(1):902-911. doi: 10.18632/aging.102663. Epub 2020 Jan 11. Aging (Albany NY). 2020. PMID: 31926110 Free PMC article.
We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent in vitro experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findin …
We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent in vitro experiments demon …
Silencing the COPB2 gene decreases the proliferation, migration and invasion of human triple-negative breast cancer cells.
Wu W, Wang C, Wang F, Wang Y, Jin Y, Luo J, Wang M, Zhang C, Wang S, Zhang F, Li M. Wu W, et al. Exp Ther Med. 2021 Aug;22(2):792. doi: 10.3892/etm.2021.10224. Epub 2021 May 24. Exp Ther Med. 2021. PMID: 34093748 Free PMC article.
The coatomer protein complex subunit beta2 (COPB2) is upregulated in various types of malignant cancer. The present study demonstrated that COPB2 expression levels were significantly upregulated in breast carcinoma HS-578T cells (clonal cells originating from …
The coatomer protein complex subunit beta2 (COPB2) is upregulated in various types of malignant cancer. The present study demo …
COPB2 gene silencing inhibits colorectal cancer cell proliferation and induces apoptosis via the JNK/c-Jun signaling pathway.
Wang Y, Xie G, Li M, Du J, Wang M. Wang Y, et al. PLoS One. 2020 Nov 19;15(11):e0240106. doi: 10.1371/journal.pone.0240106. eCollection 2020. PLoS One. 2020. PMID: 33211699 Free PMC article.
OBJECTIVES: Colorectal cancer (CRC) is one of the most common malignant human tumors. It is associated with high morbidity and mortality rates. In recent years, tumor gene therapy has emerged as a promising new approach for colorectal cancer therapy. Herein, we iden …
OBJECTIVES: Colorectal cancer (CRC) is one of the most common malignant human tumors. It is associated with high morbidity and mortal …
Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth.
Chen L, Li Q, Jiang Z, Li C, Hu H, Wang T, Gao Y, Wang D. Chen L, et al. Front Oncol. 2021 Jun 3;11:651644. doi: 10.3389/fonc.2021.651644. eCollection 2021. Front Oncol. 2021. PMID: 34150620 Free PMC article.
It has been widely studied as a therapeutic agent for the treatment of various types of cancers. The objectives of this present study were to elucidate how chrysin regulates non-coding RNA expression to exert anti-tumor effects in gastric cancer cells. METHODS: Thro …
It has been widely studied as a therapeutic agent for the treatment of various types of cancers. The objectives of this present study …
32 results